Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andréa D.E. Zomkowski"'
Autor:
Leandra C. Constantino, Andréa D.E. Zomkowski, Luisa Bandeira Binder, Fabiana K. Ludka, Ana Lúcia S. Rodrigues, Tharine Dal-Cim, Carla I. Tasca
Publikováno v:
Journal of Psychiatric Research. 82:50-57
Atorvastatin is a cholesterol-lowering statin that has been shown to exert several pleiotropic effects in the nervous system as a neuroprotective and antidepressant-like agent. Antidepressant-like effect of atorvastatin in mice is mediated by glutama
Autor:
Mauricio P. Cunha, Tharine Dal-Cim, Gislaine Kuminek, Andréa D.E. Zomkowski, Ana Lúcia S. Rodrigues, Carla I. Tasca, Luisa Bandeira Binder, Fabiana K. Ludka, Leandra C. Constantino
Publikováno v:
Pharmacology Biochemistry and Behavior. 122:253-260
Atorvastatin is a statin largely used in the treatment of hypercholesterolemia and recently revealed as a neuroprotective agent. The antidepressant-like effect of acute atorvastatin treatment in mice has been previously demonstrated by our laboratory
Autor:
Carla I. Tasca, Marcelo Maraschin, Ana Lúcia S. Rodrigues, Ana Lúcia Bertarello Zeni, Andréa D.E. Zomkowski
Publikováno v:
Journal of Ethnopharmacology. 148:914-920
Ethnopharmacological relevance Aloysia gratissima (Verbenaceae) is an aromatic plant distributed in South America and, employed in folk medicine for the treatment of nervous systems illness, including depression. The neuroprotective and antidepressan
Autor:
Ana Lúcia Bertarello Zeni, Carla I. Tasca, Tharine Dal-Cim, Ana Lúcia S. Rodrigues, Fabiana K. Ludka, Mauricio P. Cunha, Andréa D.E. Zomkowski
Publikováno v:
European Neuropsychopharmacology. 23:400-412
Atorvastatin is a synthetic and lipophilic statin that presents a good effect in decreasing cholesterol levels and is safe and well tolerated. Population-based studies have suggested a positive role of statins in reducing depression risk. This study
Autor:
Nelson H. Gabilan, Mauricio P. Cunha, Daiane Fátima Engel, Ana Lúcia S. Rodrigues, Andréa D.E. Zomkowski
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:408-417
Duloxetine is a selective serotonin and noradrenaline reuptake inhibitor used as antidepressant. However, its mechanisms of action are not fully understood. This study investigated the effect of duloxetine in the mouse forced swimming test (FST) and
Autor:
Mauricio P. Cunha, Adair R.S. Santos, Juliano C. Capra, Daniele G. Machado, Beatriz G. Mendes, Ana Lúcia S. Rodrigues, Andréa D.E. Zomkowski, Moacir Geraldo Pizzolatti
Publikováno v:
European Journal of Pharmacology. 643:232-238
The relationship between depression and monoaminergic systems has been hypothesized for many years. In this study, we have investigated the possible antidepressant-like effect of scopoletin, a coumarin from Polygala sabulosa in the tail suspension te
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30:1419-1425
Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression. Thus, this study investigated the effect of putrescine in the mouse forced swimming test (FST) and in the tai
Publikováno v:
Neuroscience Letters. 381:279-283
This study investigated the involvement of the opioid system in the antidepressant-like effect of agmatine in the mouse forced swimming test (FST). The antidepressant-like effects of agmatine (10 mg/kg, i.p.), as well as those of fluoxetine (32 mg/kg
Autor:
Jaime Lin, Andréa D.E. Zomkowski, Adair R.S. Santos, João B. Calixto, Ana Lúcia S. Rodrigues, Luciana Hammes
Publikováno v:
Neuroreport. 13:387-391
Agmatine produces an antidepressant-like effect when assessed in the forced swimming test (FST) and in the tail suspension test (TST) in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying changes in ambulation in an open-field. I.c.v. inject
Autor:
Nelson H. Gabilan, Andréa D.E. Zomkowski, Vicente Lieberknecht, Daiane Fátima Engel, Ana Lúcia S. Rodrigues
Publikováno v:
Journal of psychiatric research. 47(6)
Structural alterations in the limbic system, neuronal cell loss, and low levels of neurotrophins have been implicated in the pathogenesis of depression. While it is generally accepted that increasing monoamine levels in the brain can effectively alle