Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andréa A.S. Mendonça"'
Autor:
Aline Luciano Horta, Andréa A.S. Mendonça, Milene Lopes da Silva, André Talvani, Ana Paula de Jesus Menezes, Débora Maria Soares de Souza, Róbson Ricardo Teixeira, Ana Claudia Alvarenga Carneiro, Wagner Luiz Pereira, Guilherme de Paula Costa, Rômulo Dias Novaes
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 22, Iss, Pp 466-476 (2020)
Objective Trypanosoma cruzi infection affects millions of people worldwide, and the drugs available for its treatment have limited efficacy. 1,8-Dioxooctahydroxanthenes and tetraketones are compounds with important biological applications. The aim of
Autor:
Ana Lia Mazzeti, Thaiany G. Souza-Silva, Lívia de Figueiredo Diniz, Rômulo Dias Novaes, Reggiani Vilela Gonçalves, Andréa A.S. Mendonça
Publikováno v:
Parasitology. 146:914-927
Although leucocytes are targets of renin-angiotensin system (RAS) effector molecules and RAS-modulating drugs exert immunomodulatory effects, their impact onTrypanosoma cruziinfection remains poorly understood. By using the framework of a systematic
Autor:
Andréa A.S. Mendonça, Rômulo Dias Novaes, Jamili D.B. Santos, Rafaela C. Sousa, Reggiani Vilela Gonçalves, Thaiany Goulart de Souza e Silva, Solange M. Bigonha, Eliziária C. Santos
Publikováno v:
Food and Chemical Toxicology. 116:360-368
Remains unknown if dietary lipids and anabolic steroids (AS) can interact to modify energy metabolism, hepatic structure and function. We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholi
Autor:
Rômulo Dias Novaes, Kelly J. González-Lozano, Ivo Santana Caldas, Andréa A.S. Mendonça, Elda Gonçalves-Santos, Reggiani Vilela Gonçalves, Lívia de Figueiredo Diniz, Thaiany G. Souza-Silva
Publikováno v:
Pharmacological Research. 158:104907
Phenothiazines inhibit major antioxidant defense mechanisms in trypanosomatids and exhibit potent cytotoxic effects in vitro. However, the relevance of these drugs in the treatment of Trypanosoma cruzi-induced acute myocarditis is poorly explored, es
Autor:
Reggiani Vilela Gonçalves, Rômulo Dias Novaes, Andréa A.S. Mendonça, Elda Gonçalves-Santos, Kelly J. González-Lozano, Lívia de Figueiredo Diniz, Ivo Santana Caldas, Thaiany G. Souza-Silva
Publikováno v:
International Immunopharmacology. 85:106611
While thioridazine (Tio) inhibits the antioxidant defenses of Trypanosoma cruzi, the gold standard antitrypanosomal drug benznidazole (Bz) has potent anti-inflammatory and pro-oxidant properties. The combination of these drugs has never been tested t
Autor:
Reggiani Vilela Gonçalves, Leonardo A. de Almeida, Fernanda de Lima Tana, Amanda Aparecida Felizardo, Rômulo Dias Novaes, Andréa A.S. Mendonça, Ivo Santana Caldas
Publikováno v:
Free radical biologymedicine. 129
Elderly organisms are more susceptible to infectious diseases. However, the impact of aging on antiparasitic mechanisms, especially the nitric oxide pathway, is poorly understood. Using an integrated in vivo and in vitro model, we compared the severi
Autor:
Viviane Gorete Silveira Mouro, Reggiani Vilela Gonçalves, Eliziária C. Santos, Mariana Machado-Neves, Maria do Carmo Queiroz Fialho, Rômulo Dias Novaes, Andréa A.S. Mendonça
Publikováno v:
Environmental pollution (Barking, Essex : 1987). 242
Large amounts of aluminum (Al) are found in wastewater from industrial bauxite mining, which is often responsible for the contamination of drinking water sources in urban and rural communities. Although this metal exhibits broad environmental distrib
Autor:
Camila de Morais Coelho, Ivo Santana Caldas, Antônio Lúcio Teixeira, Reggiani Vilela Gonçalves, Aline Silva de Miranda, Andréa A.S. Mendonça, Marcia Paranho Veloso, Rômulo Dias Novaes
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Due to the rudimentary antioxidant defenses in Trypanosoma cruzi, disruptors of redox balance are promising candidates for new antitrypanosomal drugs. We developed an integrated model based on systematic review, meta-analyses, and molecular modeling
Autor:
Eliziária C. Santos, Leandro Licursi de Oliveira, Eduardo de Almeida Marques-da-Silva, Rômulo Dias Novaes, Andréa A.S. Mendonça, Daniel Silva Sena Bastos, Juliana Lopes Rangel Fietto, Marli do Carmo Cupertino, Silvia Almeida Cardoso
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Suramin (Sur) acts as anecto-NTPDase inhibitor inTrypanosoma cruziand a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shownin vitro, limited evidencein vivosuggests that this drug can be da