Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity

Autor: Timothy R D J Radstake, Joel A G van Roon, Maarten R Hillen, Sofie L M Blokland, Aridaman Pandit, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Tom Slocombe, André van Maurik

Publikováno v: RMD Open, Vol 6, Iss 2 (2020)

Externí odkaz: https://doaj.org/article/566de61c49bb45258f81094aa8bf8f1c

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome

Autor: Nicolas Wisniacki, Azeem Saleem, Paul Galette, Coziana Ciurtin, Ruth M. Tarzi, Teresa Fuller, Kathleen Port, Robert L. Janiczek, Davide Lucchesi, Calum Gray, Marius de Groot, Pilar Jimenez-Royo, Anwar R. Tappuni, Michele Bombardieri, Michalis Kostapanos, Mats Bergström, Elena Pontarini, Natasha Jordan, Nirav Ratia, André van Maurik, Neel Patel, Lucy E Kershaw, Graham E. Searle

Publikováno v: Jimenez-royo, P, Bombardieri, M, Ciurtin, C, Kostapanos, M, Tappuni, A R, Jordan, N, Saleem, A, Fuller, T, Port, K, Pontarini, E, Lucchesi, D, Janiczek, R L, Galette, P, Searle, G E, Patel, N, Kershaw, L, Gray, C, Ratia, N, van Maurik, A, de Groot, M, Wisniacki, N, Bergstrom, M & Tarzi, R 2021, ' Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's Syndrome ', Rheumatology, vol. 60, no. 5, pp. 2396–2408 . https://doi.org/10.1093/rheumatology/keaa624
Rheumatology (Oxford, England)

Objectives To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3aca584b8b2814615a95056b6a1eea
https://doi.org/10.1093/rheumatology/keaa624

Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti‐CD3ε mAb in new‐onset type 1 diabetes mellitus patients

Autor: Ruth M Barnard, David Inman, Kevin R. Page, Bart Keymeulen, Quentin Leirens, Alexander MacDonald, Antonella Napolitano, Kim Brown, David Lanham, Jonathan Bullman, Minesh Patel, André van Maurik, Enrica Mezzalana, Caroline O. S. Savage, Georgios Vlasakakis, Stefano Zamuner

Publikováno v: British Journal of Clinical Pharmacology. 85:704-714

Aims This paper describes the pharmacological findings from a study where otelixizumab, an anti-CD3ɛ mAb, was dosed in new onset Type 1 diabetes mellitus (NOT1DM) patients. This is the first time that the full dose-response of an anti-CD3ɛ mAb has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3cc8aff306a4ae44c500abe35002d5
https://doi.org/10.1111/bcp.13842

AB0496 18F-FDG-PET/CT,11C-METHIONINE-PET/CT AND MULTI-PARAMETRIC MRI IN THE EVALUATION OF DISEASE ACTIVITY AND GLAND FUNCTION IN PRIMARY SJÖGREN’S SYNDROME

Autor: Anwar R. Tappuni, Graham Searle, Nicolas Wisniacki, Michele Bombardieri, Mats Bergström, Ruth M. Tarzi, Natasha Jordan, Teresa Fuller, Nirav Ratia, Michalis Kostapanos, Rob Janiczek, Neel Patel, Kathleen Port, Lucy E Kershaw, Paul Galette, Elisa Astorri, Pilar Jimenez-Royo, Saleem Azeem, Marius de Groot, Calum Gray, Coziana Ciurtin, André van Maurik

Publikováno v: Abstracts Accepted for Publication.

Background: Saliva and tear flow rates and minor salivary gland biopsy are typically used to assess gland function and disease activity in primary Sjogren’s syndrome (pSS); however, these have limitations. Imaging methods can directly visualize and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aceb82ce4fcec439c8cb2157cb6e7f2b
https://doi.org/10.1136/annrheumdis-2019-eular.7050

Induced CD8+FoxP3+ Treg Cells in Rheumatoid Arthritis Are Modulated by p38 Phosphorylation and Monocytes Expressing Membrane Tumor Necrosis Factor α and CD86

Autor: David C. Howe, Clare A. Notley, Shawn D P Ellis, Jenny L. McGovern, André van Maurik, Michael R. Ehrenstein

Publikováno v: Arthritis & Rheumatology. 66:2694-2705

Objective Limiting the severity of inflammation and promoting its eventual resolution are vital for protecting host tissues both in autoimmunity and chronic infection. The aim of this study was to determine the suitability of repurposing anti-CD3 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8e8d0c43881980a8d60f00942f413aa
https://doi.org/10.1002/art.38761