Improved lipid profile through liver-specific knockdown of liver X receptor α in KKAy diabetic mice

Autor: Joerg F. Rippmann, Corinna Schoelch, Thomas Nolte, Heidi Pavliska, André van Marle, Helmuth van Es, Juergen Prestle

Publikováno v: Journal of Lipid Research, Vol 50, Iss 1, Pp 22-31 (2009)

Nuclear hormone receptors liver X receptor (LXRα and LXRβ) ligands are attractive approaches for the treatment of dyslipidemia and atherosclerosis. To further elucidate the function of LXRα in liver lipid metabolism in a disease-relevant animal mo

Externí odkaz: https://doaj.org/article/007ef95c9ca942159728bab691792fba

A Flow-Through Fluorescence Polarization Detection System for Measuring GPCR-Mediated Modulation of cAMP Production

Autor: André van Marle, Klaas van Altena, Hubertus Irth, Jeroen Kool, Maurice H. J. Selman, Saskia Hulscher, Remko A. Bakker, Michel Gillard, Rob Leurs, Nico P. E. Vermeulen, Dick J. van Iperen

Publikováno v: Kool, J, van Marle, A, Hulscher, ST, Selman, M, van Iperen, D J, van Altena, K, Gillard, M R, Bakker, R A, Irth, H, Leurs, R & Vermeulen, N P E 2007, ' A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production ', Journal of Biomolecular Screening, vol. 12, no. 8, pp. 1074-83 . https://doi.org/10.1177/1087057107308881
Journal of Biomolecular Screening, 12(8), 1074-83. SAGE Publications Inc.

A flow-through fluorescence polarization (FP) detection system that makes use of a novel high-performance liquid chromatography (HPLC) fluorescence detector modified with polarization filters was developed. This flow-through FP detection system was e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f90aded131aa3cfae1dbadea96988
https://doi.org/10.1177/1087057107308881

Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms

Autor: Guillaume Drutel, Paul L. Chazot, André van Marle, Kaj Karlstedt, Fiona C. Shenton, Marcel Hoffmann, Pertti Panula, Minnamaija Lintunen, Remko A. Bakker, Rob Leurs, Yumiko Yamamoto, Adrian F. Lozada, Richard M. van Rijn

Publikováno v: Molecular Pharmacology, 69(4), 1194-206. American Society for Pharmacology and Experimental Therapeutics
Bakker, R A, Lozada, A F, van Marle, A, Shenton, F C, Drutel, G H M, Karlstedt, K, Hoffmann, M, Lintunen, M, Yamamoto, Y, van Rijn, R, Chazot, P L, Panula, P & Leurs, R 2006, ' Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms ', Molecular Pharmacology, vol. 69, no. 4, pp. 1194-206 . https://doi.org/10.1124/mol.105.019299
University of Helsinki

We described previously the cDNA cloning of three functional rat histamine H3 receptor (rH3R) isoforms as well as the differential brain expression patterns of their corresponding mRNAs and signaling properties of the resulting rH3A, rH3B, and rH3C r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29361ee24b3b9f82380acb283c536140
https://doi.org/10.1124/mol.105.019299

Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis

Autor: Mark G. Darlison, Brien P. Riley, Michael Mullan, Thomas Sander, Dieter Janz, André van Marle, Keith J. Johnson, Andrew A. Hicks

Publikováno v: Genomics. 14:745-748

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5eaf15390f446483ae28332ac40030a
https://doi.org/10.1016/s0888-7543(05)80178-8

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor

Autor: Kamonchanok Sansuk, Paul L. Chazot, Remko A. Bakker, Richard M. van Rijn, Rob Leurs, Yongjun Qin, Fiona C. Shenton, Michel Dy, Obbe P. Zuiderveld, André van Marle, Cornelis P. Tensen, Ellen Langemeijer, Martine J. Smit, Herman D. Lim

Publikováno v: van Rijn, R, van Marle, A, Chazot, P L, Langemeijer, E V, Qin, Y, Shenton, F C, Lim, H D, Zuiderveld, O P, Sansuk, K, Dy, M, Smit, M J, Tensen, C P, Bakker, R A & Leurs, R 2008, ' Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor ', Biochemical Journal, vol. 414, no. 1, pp. 121-31 . https://doi.org/10.1042/BJ20071583
Biochemical Journal
Biochemical Journal, Portland Press, 2008, 414, pp.121-131
Biochem. J.
Biochem. J., 2008, 414, pp.121-131
Biochemical Journal, 414(1), 121-31. Portland Press Ltd.

The H(4)R (histamine H(4) receptor) is the latest identified member of the histamine receptor subfamily of GPCRs (G-protein-coupled receptors) with potential functional implications in inflammatory diseases and cancer. The H(4)R is primarily expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21f4855d0bac77b7f8b754d2d09e04a
https://hal.archives-ouvertes.fr/hal-00323634