Zobrazeno 1 - 10
of 16
pro vyhledávání: '"André X. C. N. Valente"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48653 (2012)
Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy p
Externí odkaz:
https://doaj.org/article/89abea5092914630b59f3419c1ea003c
Autor:
André X. C. N. Valente, Albert A. Rizvanov, Svetlana F. Khaiboullina, Paulo J. Oliveira, András Palotás
Publikováno v:
Current Drug Metabolism. 14:814-818
Life sciences are experiencing a historical shift towards a quantitative, data-rich regime. This transition has been associated with the advent of bio-informatics: mathematicians, physicists, computer scientists and statisticians are now commonplace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b71850bef6e0373d77642070eeba19
https://doi.org/10.2174/13892002113149990100
https://doi.org/10.2174/13892002113149990100
Publikováno v:
Central Asian Journal of Global Health
Central Asian Journal of Global Health, Vol 5, Iss 1 (2016)
Central Asian Journal of Global Health, Vol 5, Iss 1 (2016)
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, yet the etiology of the majority of its cases remains unknown. In this manuscript, relevant published evidence is interpreted and integrated into a comprehensive hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0285aa7ce2ffad5bb03a91961a3c764
https://doi.org/10.7287/peerj.preprints.1314v1
https://doi.org/10.7287/peerj.preprints.1314v1
Publikováno v:
International Journal of Non-Linear Mechanics. 38:677-689
We consider two linearly coupled masses, where one mass can have inelastic impacts with a fixed, rigid stop. This leads to the study of a two degree of freedom, piecewise linear, frictionless, unforced, constrained mechanical system. The system is go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c437e5c2d5d95133aa56bcbac6fedd64
https://doi.org/10.1016/s0020-7462(01)00126-3
https://doi.org/10.1016/s0020-7462(01)00126-3
Publikováno v:
Parkinsonismrelated disorders. 18(6)
Nature, initiation and ensuing cellular propagation mode of sporadic Parkinson’s disease (comprising over 90% of all Parkinson’s cases) remain open research questions. Accordingly, so does the best therapeutic avenue for addressing this debilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540d6b33b24d429662aa7a9825b07950
https://pubmed.ncbi.nlm.nih.gov/22578978
https://pubmed.ncbi.nlm.nih.gov/22578978
Publikováno v:
Scientific Reports
An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ece74bfdd89546f3c5fd16fdb8c41c
https://doi.org/10.1038/srep00256
https://doi.org/10.1038/srep00256
A transcriptome-wide blood expression dataset of Parkinson’s disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of the proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0deea9cf55a1526df9187ae5cd0783
http://arxiv.org/abs/1003.1993
http://arxiv.org/abs/1003.1993
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(5)
It is hoped that comprehensive mapping of protein physical interactions will facilitate insights regarding both fundamental cell biology processes and the pathology of diseases. To fulfill this hope, good solutions to 2 issues will be essential: ( i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fecd7c715099d87788e7ee303256bf
https://pubmed.ncbi.nlm.nih.gov/19164585
https://pubmed.ncbi.nlm.nih.gov/19164585
Publikováno v:
Journal of the Royal Society Interface
P olar M apper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398a382bad2fecf77ba0d35533fdeaa7
https://pubmed.ncbi.nlm.nih.gov/19091689
https://pubmed.ncbi.nlm.nih.gov/19091689
Publikováno v:
Nature Precedings
Polar Mapper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b569622563925528a15f1df2111709f6
https://doi.org/10.1038/npre.2008.2663.1
https://doi.org/10.1038/npre.2008.2663.1