Zobrazeno 1 - 10
of 55
pro vyhledávání: '"André T Brunetto"'
Autor:
Maria Eduarda Battistella, Natália Hogetop Freire, Bruno Toson, Matheus Dalmolin, Marcelo A. C. Fernandes, Isadora D. Tassinari, Mariane Jaeger, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Rafael Roesler
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 3990-4003 (2024)
Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-ES-1 ES cel
Externí odkaz:
https://doaj.org/article/b0e933e8b0a2419ca47b31f833d979cc
Autor:
Rafael Pereira, Dos Santos, Lauro, Gregianin, André, T Brunetto, Mariane, da Cunha Jaeger, Algemir, Lunardi Brunetto, Caroline, Brunetto de Farias, Rafael, Roesler
Publikováno v:
Current Stem Cell Research & Therapy. 18:926-936
Abstract: Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18146f761033315795837b37df1ea710
https://doi.org/10.2174/1574888x17666220627114710
https://doi.org/10.2174/1574888x17666220627114710
Autor:
Alexandre Perla, Lívia Fratini, Paula S. Cardoso, Carolina Nör, André T. Brunetto, Algemir L. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during embryonal development of the nervous system. Histone acetylation is one of the most widely inve
Externí odkaz:
https://doaj.org/article/656536c4d17a43e08d31ac160e2405b5
Autor:
Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D. Taylor, Rafael Roesler
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated
Externí odkaz:
https://doaj.org/article/b5b0e0b16162448d9954f355f8f89f01
Autor:
Johann S. de Bono, Bernd Hentsch, Vera Strobel, Bernhard Hauns, Anna Mais, Muyibat Olaleye, Isabel Casamayor, Ann Parker, Rebecca Kristeleit, L. Rhoda Molife, David Olmos, Rohit Lal, Joo Ern Ang, André T. Brunetto
Supplementary figure 1. Plot of resminostat concentration versus degree of HDAC enzyme inhibition at 2 hour post-dose on day 1 for all dose levels using the Hill model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39630264a00477f0eaf1ad5fce361f3e
https://doi.org/10.1158/1078-0432.22449708
https://doi.org/10.1158/1078-0432.22449708
Autor:
Johann S. de Bono, Bernd Hentsch, Vera Strobel, Bernhard Hauns, Anna Mais, Muyibat Olaleye, Isabel Casamayor, Ann Parker, Rebecca Kristeleit, L. Rhoda Molife, David Olmos, Rohit Lal, Joo Ern Ang, André T. Brunetto
Purpose: This first-in-human dose-escalating trial investigated the safety, tolerability, maximum tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and pharmacodynamics of the novel histone deacetylase (HDAC) inhibitor resminost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd977a53f75aaff9fa343237ed1641
https://doi.org/10.1158/1078-0432.c.6521730
https://doi.org/10.1158/1078-0432.c.6521730
Autor:
Lisa Shaw, Lívia Fratini, Mariane da Cunha Jaeger, André T Brunetto, Rafael Roesler, Algemir Lunardi Brunetto, Caroline Brunetto de Farias
Publikováno v:
Molecular and Cellular Biochemistry. 476:4107-4116
The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including driving epithelial-mesenchymal transition. Several aspects of ZEB1 function can be regulated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b8ad998337f53dc533e07dfc42c587
https://doi.org/10.1007/s11010-021-04226-x
https://doi.org/10.1007/s11010-021-04226-x
Autor:
Manoela Domingues Martins, Lauro José Gregianin, Marina Curra, André T Brunetto, Maria Beatriz Cardoso Ferreira, Amanda de Farias Gabriel, Marco Antonio Trevizani Martins
Publikováno v:
Supportive Care in Cancer. 29:6243-6251
To investigate the incidence and risk factors for oral mucositis (OM) in patients with childhood cancer undergoing chemotherapy. Eight hundred and twenty-nine cycles of chemotherapy were evaluated in 112 patients with childhood cancer undergoing chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::220cb0dce8b094cd6f6b18ca01ac3696
https://doi.org/10.1007/s00520-021-06199-5
https://doi.org/10.1007/s00520-021-06199-5
Autor:
Livia Fratini, Matheus Gibeke Siqueira Dalmolin, Marialva Sinigaglia, Alexandre da Silveira Perla, Caroline Brunetto de Farias, Algemir L. Brunetto, André T. Brunetto, Mariane da Cunha Jaeger, Rafael Roesler
Publikováno v:
Neuromolecular medicine.
Medulloblastoma (MB) is a malignant brain tumor that afflicts mostly children and adolescents and presents four distinct molecular subgroups, known as WNT, SHH, Group 3, and Group 4. ZEB1 is a transcription factor that promotes the expression of mese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932a77f5c4c5a6df7dad53d576f145ba
https://pubmed.ncbi.nlm.nih.gov/35716340
https://pubmed.ncbi.nlm.nih.gov/35716340
Autor:
Barbara Kunzler Souza, Natalia Hogetop Freire, Mariane Jaeger, Caroline Brunetto de Farias, Algemir L. Brunetto, André T. Brunetto, Rafael Roesler
Publikováno v:
Neuromolecular medicine. 24(4)
Changes in epigenetic programming are associated with cancer development during childhood. Components of the epigenetic machinery involved in normal embryonic development and hijacked by pediatric cancers include enzymes mediating post-translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da627ec122c5c6deca992410729580b
https://pubmed.ncbi.nlm.nih.gov/35113321
https://pubmed.ncbi.nlm.nih.gov/35113321