Zobrazeno 1 - 9
of 9
pro vyhledávání: '"André Spychala"'
Autor:
Daniel Oehler, André Spychala, Axel Gödecke, Alexander Lang, Norbert Gerdes, Jorge Ruas, Malte Kelm, Julia Szendroedi, Ralf Westenfeld
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially r
Externí odkaz:
https://doaj.org/article/495a14a532db4ff7926a59c08eaaa298
Autor:
Rianne Nederlof, Sophia Reidel, André Spychala, Stefanie Gödecke, André Heinen, Tobias Lautwein, Patrick Petzsch, Karl Köhrer, Axel Gödecke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute myocardial infarction (MI) induces an extensive sterile inflammation, which is dominated in the early phase by invading neutrophils and monocytes/macrophages. The inflammatory response after MI critically affects infarct healing and cardiac rem
Externí odkaz:
https://doaj.org/article/ddfa61368cbc44b1ba436e2e13f4bc20
Autor:
André Spychala, Ulrich Rüther
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211937 (2019)
Initially, the function of the fat mass and obesity associated (Fto) gene seemed to be primarily the regulation of the body weight. Here we show that loss of Fto results in a hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. In conseq
Externí odkaz:
https://doaj.org/article/8cec28730c4345f5a7ab451132c3c204
Autor:
Dominika Miklos, Katharina Bottermann, Ulrich Flögel, Stefanie Gödecke, Axel Gödecke, André Heinen, André Spychala
Publikováno v:
Basic Research in Cardiology
Conditional, cell-type-specific transgenic mouse lines are of high value in cardiovascular research. A standard tool for cardiomyocyte-restricted DNA editing is the αMHC-MerCreMer/loxP system. However, there is an ongoing debate on the occurrence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7301764fead6c47c61022314d0e69fa3
https://doi.org/10.1007/s00395-020-00841-9
https://doi.org/10.1007/s00395-020-00841-9
Autor:
Axel Gödecke, André Spychala, Andre Heinen, Rianne Nederlof, Priyadarshini Panjwani, Tengis Tschaidse
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35527ea5ad76e296747a02fbe31f7f2b
https://doi.org/10.1096/fasebj.2019.33.1_supplement.690.5
https://doi.org/10.1096/fasebj.2019.33.1_supplement.690.5
Autor:
Ulrich Rüther, André Spychala
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211937 (2019)
PLoS ONE
PLoS ONE
Initially, the function of the fat mass and obesity associated (Fto) gene seemed to be primarily the regulation of the body weight. Here we show that loss of Fto results in a hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. In conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5739cba359b764fd0be59f1cf7bcda
https://doaj.org/article/8cec28730c4345f5a7ab451132c3c204
https://doaj.org/article/8cec28730c4345f5a7ab451132c3c204
Autor:
Rianne Nederlof, Priyadarshini Panjwani, Axel Gödecke, Alexandra Zimmerhofer, André Spychala, André Heinen
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ed8765d43bc4df8055f58dda64a3f6
https://doi.org/10.1096/fasebj.2020.34.s1.03252
https://doi.org/10.1096/fasebj.2020.34.s1.03252
Autor:
Philipp A. Lang, Heiko Reffelt, Christina Alter, Rianne Nederlof, André Heinen, Priyadarshini Panjwani, Jelena Vasilevska, Annika Raupach, Maria Grandoch, Tengis Tschaidse, Johannes Boy, Anne Petz, Karl Köhrer, André Spychala, Axel Gödecke, Patrick Petzsch, Jens W. Fischer, Stefanie Gödecke
Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute myocardial infarction (AMI), but the underlying mechanisms and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aad09c174a99e940775c8a2b4f84968
https://europepmc.org/articles/PMC6319026/
https://europepmc.org/articles/PMC6319026/
Autor:
Tristan Leu, Antonia Wiegering, Andreas Struchtrup, Sophie Saunier, André Spychala, Stefanie Dahmen, Stefanie Kuschel, Christoph Gerhardt, Flora Legendre, Ulrich Rüther, Renate Dildrop, Thomas Zobel, Lisa Kalfhues, Sylvie Schneider-Maunoury, Johanna Maria Lier, Christine Vesque
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal, 2018, 37 (10), ⟨10.15252/embj.201797791⟩
EMBO Journal
EMBO Journal, 2018, 37 (10), ⟨10.15252/embj.201797791⟩
International audience; Ciliopathies are life-threatening human diseases caused by defective cilia. They can often be traced back to mutations of genes encoding transition zone (TZ) proteins demonstrating that the understanding of TZ organisation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaf3317bb3be7edf654c4ca11d9ed6d
https://doi.org/10.15252/embj.201797791
https://doi.org/10.15252/embj.201797791