Výsledky vyhledávání - "André Schaeftlein"

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin

Autor: André Schaeftlein, Robin Michelet, Alexander Solms, Wilhelm Huisinga, David Busse, Luis Ilia, Charlotte Kloft, Markus Zeitlinger

Publikováno v: Pharmaceutical Research

Purpose Systematic comparison of analysis methods of clinical microdialysis data for impact on target-site drug exposure and response. Methods 39 individuals received a 500 mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43597d570eeb6ff3f30c9f3811dec4ee
https://pubmed.ncbi.nlm.nih.gov/33723793

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Clinical Determinants of Target Non-Attainment of Linezolid in Plasma and Interstitial Space Fluid: A Pooled Population Pharmacokinetic Analysis with Focus on Critically Ill Patients

Autor: André Schaeftlein, Joseph L. Kuti, Iris K. Minichmayr, Charlotte Kloft, Markus Zeitlinger

Publikováno v: Clinical Pharmacokinetics. 56:617-633

We aimed to assess linezolid pharmacokinetics in the plasma and interstitial space fluid (ISF) of patients with sepsis, diabetic foot infections or cystic fibrosis and healthy volunteers. The impacts of joint characteristics and disease on plasma and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dab29e41ed429e9ec760aaf2036dbd2
https://doi.org/10.1007/s40262-016-0463-7

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Population pharmacokinetics meets microdialysis: Benefits, pitfalls and necessities of new analysis approaches for human microdialysis data

Autor: André Schaeftlein, Charlotte Kloft, Iris K. Minichmayr

Publikováno v: European Journal of Pharmaceutical Sciences. 57:68-73

Pharmacokinetic (PK) data originating from human microdialysis studies have by now most commonly been analysed using noncompartmental analysis or the standard two-stage population approach. During the last decades, additional modelling strategies for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18dbd042828d9d339eb018e2c29212a
https://doi.org/10.1016/j.ejps.2013.11.004

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Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients

Autor: Frieder Kees, Alexandra Heininger, Helene A. Haeberle, Charlotte Kloft, Martin G. Kees, André Schaeftlein

Publikováno v: The Journal of antimicrobial chemotherapy. 68(6)

OBJECTIVES: To describe the plasma concentration-time profile of moxifloxacin after intravenous and enteral administration in intensive care unit (ICU) patients and to provide a pharmacodynamic (PD) evaluation with regard to pneumonia. PATIENTS AND M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2676198ea2266e4e0138491ffeef0c3
https://pubmed.ncbi.nlm.nih.gov/23463212

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