Zobrazeno 1 - 10
of 101
pro vyhledávání: '"André S. Bachmann"'
Autor:
Chad R. Schultz, Ryan D. Sheldon, Huirong Xie, Elena Y. Demireva, Katie L. Uhl, Dalen W. Agnew, Dirk Geerts, André S. Bachmann
Publikováno v:
Biology Open, Vol 12, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/ff03a24cbd904c6da12eb4d5b15a39df
Autor:
Julianne Michael, Elizabeth VanSickle, Marlie Vipond, Abby Dalman, Jeremy Prokop, Charles E. Schwartz, Surender Rajasekaran, André S. Bachmann, Magalie Barth, Clément Prouteau, Yotam Almagor, Lina Berkun, Gheona Alterescu, Caleb P. Bupp
Publikováno v:
Medical Sciences, Vol 11, Iss 2, p 29 (2023)
Recent identification of four additional polyaminopathies, including Bachmann–Bupp syndrome, have benefited from previous research on Snyder–Robinson syndrome in order to advance from research to treatment more quickly. As a result of the discove
Externí odkaz:
https://doaj.org/article/6c50033ad1b24e8d863ee9b47432b374
Autor:
Shao Thing Teoh, Mara L. Leimanis-Laurens, Sarah S. Comstock, John W. Winters, Nikita L. Vandenbosch, Jeremy W. Prokop, André S. Bachmann, Sophia Y. Lunt, Surender Rajasekaran
Publikováno v:
Metabolites, Vol 12, Iss 2, p 178 (2022)
A large percentage of infants develop viral bronchiolitis needing medical intervention and often develop further airway disease such as asthma. To characterize metabolic perturbations in acute respiratory syncytial viral (RSV) bronchiolitis, we compa
Externí odkaz:
https://doaj.org/article/8ff488b0f8ec49a0a74cf4da79d0ac4f
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxi
Externí odkaz:
https://doaj.org/article/034a949a8dae47a8a05142e7fd3f8755
Publikováno v:
Medical Sciences, Vol 6, Iss 3, p 65 (2018)
Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynth
Externí odkaz:
https://doaj.org/article/70a38a54a3964e36a5ef76985e81210c
Autor:
Surender Rajasekaran, Caleb P Bupp, Mara Leimanis-Laurens, Ankit Shukla, Christopher Russell, Joseph Junewick, Emily Gleason, Elizabeth A VanSickle, Yvonne Edgerly, Bryan M Wittmann, Jeremy W Prokop, André S Bachmann
Publikováno v:
eLife, Vol 10 (2021)
Background: Polyamine levels are intricately controlled by biosynthetic, catabolic enzymes and antizymes. The complexity suggests that minute alterations in levels lead to profound abnormalities. We described the therapeutic course for a rare syndrom
Externí odkaz:
https://doaj.org/article/1498a58c840f461ba483dbb1a62257c5
Autor:
X. Edward Zhou, Chad R. Schultz, Kelly Suino Powell, Amy Henrickson, Jared Lamp, Joseph S. Brunzelle, Borries Demeler, Irving E. Vega, André S. Bachmann, Karsten Melcher
Publikováno v:
ACS Omega. 7:34665-34675
Ornithine decarboxylase (ODC) is a rate-limiting enzyme for the synthesis of polyamines (PAs). PAs are required for proliferation, and increased ODC activity is associated with cancer and neural over-proliferation. ODC levels and activity are therefo
Autor:
André S. Bachmann, Anthony E. Pegg, Ivonne Gamper, Christopher J. Wallick, Craig C. Coleman, David J. Feith, Tamas Borsics, Dana-Lynn T. Koomoa
S-adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme of polyamine (PA) biosynthesis, and both AdoMetDC and PA levels are often up-regulated in cancer cells. The second-generation inhibitor SAM486A inhibits AdoMetDC enzyme activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce8a5ab05ca9a6df6c1da8c2fcccff5
https://doi.org/10.1158/1535-7163.c.6531927.v1
https://doi.org/10.1158/1535-7163.c.6531927.v1
Autor:
André S. Bachmann, Ramon Christopher V. Go, Rogier Versteeg, Jan Koster, Dana-Lynn T. Koomoa, Christopher J. Wallick, Dirk Geerts
Purpose: Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is a novel 19-kDa protein that has recently been implicated in human cancer. In the present study, we analyzed for the first time PRAF2 mRNA expression in a large set of human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46de6792ee936e2a2be22556d42dbf7f
https://doi.org/10.1158/1078-0432.c.6516987.v1
https://doi.org/10.1158/1078-0432.c.6516987.v1
Autor:
André S. Bachmann, Ramon Christopher V. Go, Rogier Versteeg, Jan Koster, Dana-Lynn T. Koomoa, Christopher J. Wallick, Dirk Geerts
Supplementary Tables S1-S2 from Expression of Prenylated Rab Acceptor 1 Domain Family, Member 2 (PRAF2) in Neuroblastoma: Correlation with Clinical Features, Cellular Localization, and Cerulenin-Mediated Apoptosis Regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db10f73f5112c22eeeb1a103314e239
https://doi.org/10.1158/1078-0432.22439538
https://doi.org/10.1158/1078-0432.22439538