Zobrazeno 1 - 10
of 31
pro vyhledávání: '"André Richters"'
Autor:
Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C. Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcin
Externí odkaz:
https://doaj.org/article/65260813004b4d5e8d198b9f59d2baa6
Autor:
Roman K. Thomas, Jürgen Wolf, Lukas C. Heukamp, Reinhard Büttner, Francois Ringeisen, H. Christian Reinhardt, Roland T. Ullrich, Thomas Zander, Daniel Rauh, Steffi Silling, Julie George, Srivari Chandrasekhar, Nagaraju Karre, Prathama S. Mainkar, Alexandra Florin, Martin Peifer, André Richters, Frauke Leenders, Danila Seidel, Marc Bos, Matthias Scheffler, Masyar Gardizi, Dennis Plenker, Joachim Diebold, Oliver Gautschi, Johannes M. Heuckmann, Lynnette Fernandez-Cuesta, Kerstin Albus, Lucia Nogova, Xin Lu, Jakob Schöttle, Felix Dietlein, Florian Malchers
PDF file 136K,Methods: Additional information on experimental techniques and data analysis. Legends: describing supplementary figures S1-S14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5cc41fa20095c9341ef451390a6d5f
https://doi.org/10.1158/2159-8290.22529610
https://doi.org/10.1158/2159-8290.22529610
Autor:
Roman K. Thomas, Jürgen Wolf, Lukas C. Heukamp, Reinhard Büttner, Francois Ringeisen, H. Christian Reinhardt, Roland T. Ullrich, Thomas Zander, Daniel Rauh, Steffi Silling, Julie George, Srivari Chandrasekhar, Nagaraju Karre, Prathama S. Mainkar, Alexandra Florin, Martin Peifer, André Richters, Frauke Leenders, Danila Seidel, Marc Bos, Matthias Scheffler, Masyar Gardizi, Dennis Plenker, Joachim Diebold, Oliver Gautschi, Johannes M. Heuckmann, Lynnette Fernandez-Cuesta, Kerstin Albus, Lucia Nogova, Xin Lu, Jakob Schöttle, Felix Dietlein, Florian Malchers
PDF file 34156K, Table of genes from 16 recurrent amplified genomic regions (Figure S1), amplicon focality on TCGA copy number aberrations (Figure S2), hierarchical clustering of CLCGP copy number data (Figure S3), centrality frequencies of common ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa55b970728bba259689298cf12daa2
https://doi.org/10.1158/2159-8290.22529613
https://doi.org/10.1158/2159-8290.22529613
Publikováno v:
Cancer Research. 83:3409-3409
Cyclin-dependent kinase 9 (CDK9) has long been considered an attractive therapeutic target for modulating transcription in cancers of high unmet clinical need. CDK9 coordinates signaling events that regulate RNA polymerase II (Pol II) pause-release s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658bc122501e545b7994c93926a4f84b
https://doi.org/10.1158/1538-7445.am2023-3409
https://doi.org/10.1158/1538-7445.am2023-3409
Autor:
André Richters, Sven Hennig
Publikováno v:
Drug discovery today. Technologies. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fb40e0c5fbe3b9c420a9b96f14ac5d
https://pubmed.ncbi.nlm.nih.gov/34916016
https://pubmed.ncbi.nlm.nih.gov/34916016
Autor:
Felix Dietlein, Roman K. Thomas, Martin Peifer, Daniel Rauh, Zoltán Varga, Johannes M. Heuckmann, Axel Choidas, Johannes Brägelmann, Jan Eickhoff, Carina Lorenz, Hyatt Balke-Want, György Kéri, Zhizhou Fang, Stefanie Böhm, Zoltán Greff, Muhammad Sallouh, Martin Termathe, Reinhard Büttner, Debjit Basu, Christopher A. French, Uwe Koch, Frauke Leenders, André Richters, Martin L. Sos, Verena Tischler, Bert Klebl, Sascha Ansén, Peter Habenberger, Laszlo Orfi, Matthäus Getlik, Sandra Ortiz-Cuaran, Marcel A. Dammert, Lukas C. Heukamp, H. Christian Reinhardt
Publikováno v:
Cell Reports
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Summary Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfadea6b1ad3b4323f2fa27e4edbd58
http://europepmc.org/articles/PMC5622049
http://europepmc.org/articles/PMC5622049
Autor:
Shamil R. Sunyaev, Brendan Reardon, David Liu, Donate Weghorn, André Richters, Amaro Taylor-Weiner, Eliezer M. Van Allen, Eric S. Lander, Felix Dietlein
Publikováno v:
Nature genetics
PMC
PMC
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c703f55b03bc9c501fc8df92099f93b
https://pubmed.ncbi.nlm.nih.gov/32015527
https://pubmed.ncbi.nlm.nih.gov/32015527
Autor:
Brendan Reardon, Shamil R. Sunyaev, David Liu, Donate Weghorn, André Richters, Amaro Taylor-Weiner, Eliezer M. Van Allen, Felix Dietlein, Eric S. Lander
Many cancer genomes contain large numbers of somatic mutations, but few of these mutations drive tumor development. Current approaches to identify cancer driver genes are largely based on mutational recurrence, i.e. they search for genes with an incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590903595cdb89b761f2561accf25169
Autor:
Thomas F. Westbrook, Jonathan Branch, Joseph Vacca, Julie Urgiles, Marius S. Pop, Christina Lee, Marco Gottardis, Ian Hickson, Peter J. Mikochik, Stefan Knapp, Ryan A. Stagg, Chris M. Wilfong, Norbert Bischofberger, Tamara D. Hopkins, Jost Vrabic Koren, Shelby K. Doyle, Sebastian Mathea, Brent A. Rupnow, Steven P. Balk, Deep Chatterjee, Hong Xin, Kristen L. Karlin, Douglas C. Saffran, Hua Gao, Nicholas B. Struntz, Gilles Bignan, David B. Freeman, Angela N. Koehler, Calla M. Olson, Sajjeev Jagannathan, B. Wesley Trotter, Brice Harrison Curtin, Charles Y. Lin, James R. Bischoff, Becky S Leifer, Florian Kabinger, Lori Westover, André Richters, Joshua W. Russo
Publikováno v:
Cell Chemical Biology. 28:134-147.e14
Summary Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e1e1f3eea8bcbb80f39ae718bc7146
https://doi.org/10.1016/j.chembiol.2020.10.001
https://doi.org/10.1016/j.chembiol.2020.10.001
Autor:
Christopher Wilfong, André Richters, Angela N. Koehler, Charles Y. Lin, Christina O. Lee, Becky S Leifer, Sajjeev Jagannathan, Doug Saffran, Joseph Vacca, Kristen L. Karlin, Norbert Bischofberger, Jost Vrabic Koren, Shelby K. Doyle, David B. Freeman, Florian Kabinger, Calla M. Olson, Peter J. Mikochik, Marius S. Pop
Publikováno v:
Cancer Research. 80:1771-1771
Castration resistant prostate cancers (CRPCs) lose sensitivity to hormone therapy, but remain dependent on oncogenic transcription programs driven by the androgen receptor (AR) and other oncogenic transcription factors such as MYC. Using small molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64dbb692779e5985182fe99710d931ac
https://doi.org/10.1158/1538-7445.am2020-1771
https://doi.org/10.1158/1538-7445.am2020-1771