Zobrazeno 1 - 10
of 46
pro vyhledávání: '"André Poupart"'
Autor:
Nelu Grinberg, Marc-André Poupart, Jon C. Lorenz, Bo Qu, Nizar Haddad, Nina C. Gonnella, Shengli Ma, Nathan K. Yee, Wenjun Tang, Jiang-Ping Wu, Youla S. Tsantrizos, Wenjie Li, Joe Gao, Kanwar Sidhu, June Wang, Nitinchandra D. Patel, Sonia Rodriguez, Sanjit Sanyal, Heewon Lee, Yongda Zhang, Carl A. Busacca, Diana C. Reeves, Bruce Z. Lu, Keith R. Fandrick, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 127:7250-7254
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d20ec4749c7a46e4ef82931f7fe303e
https://doi.org/10.1002/ange.201501575
https://doi.org/10.1002/ange.201501575
Autor:
André Poupart
Pourquoi Averroès? Pourquoi Averroès juriste? Parce que dans le cadre du débat avec ceux qui soutiennent le caractère indubitable du texte sacré, Averroès affirme la primauté de la raison. Il a ainsi mis en avant le questionnement, le doute da
Autor:
Christian Brochu, James Gillard, Michael Bös, Martin Marquis, Richard Bethell, Gulrez Fazal, George Kukolj, Michel Garneau, Timothy A. Stammers, Paul C. Anderson, Dominik Wernic, Pierre L. Beaulieu, Stephen H. Kawai, Ginette McKercher, Marc-André Poupart, Jianmin Duan, Bounkham Thavonekham, Yves Bousquet, Michael G. Cordingley
Publikováno v:
Journal of Medicinal Chemistry. 57:10130-10143
The development of interferon-free regimens for the treatment of chronic HCV infection constitutes a preferred option that is expected in the future to provide patients with improved efficacy, better tolerability, and reduced risk for emergence of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c2526b2206e311f04252cc1bdbf310
https://doi.org/10.1021/jm501532z
https://doi.org/10.1021/jm501532z
Autor:
Nathalie Rioux, Sonia Tremblay, Michel Garneau, Pierre R. Bonneau, René Coulombe, Marc-André Poupart, Bruno Simoneau, Steve Mason, Louie Lamorte, Patricia Schroeder, Stephen H. Kawai, Jianmin Duan, Ma’an Amad, Laibin Luo, Lee Fader, Anne-Marie Faucher, Steven R. LaPlante, Craig Fenwick, Araz Jakalian, Michael Bös, Youla S. Tsantrizos, Paul J. Edwards, Myriam Witvrouw, Murray D. Bailey, Michael G. Cordingley, Richard Bethell, Christiane Yoakim
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3233-3244
BI 224436 is an HIV-1 integrase inhibitor with effective antiviral activity that acts through a mechanism that is distinct from that of integrase strand transfer inhibitors (INSTIs). This 3-quinolineacetic acid derivative series was identified using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1eee31c986fed387f5f7398f1e29bb1
https://doi.org/10.1128/aac.02719-13
https://doi.org/10.1128/aac.02719-13
Autor:
Marc Pesant, Christian Brochu, Rebekah J. Carson, Bruno Simoneau, Patricia Schroeder, Murray D. Bailey, Pierre R. Bonneau, Michael G. Cordingley, Catherine Chabot, Michel Garneau, Anne-Marie Faucher, Michael Bös, René Coulombe, Mathieu Parisien, Stephen W. Mason, Araz Jakalian, Jianmin Duan, Marc-André Poupart, Dominik Wernic, Sébastien Morin, François Bilodeau, Serge Landry, Yves Bousquet, Eric Malenfant, Stephen H. Kawai, Punit Bhardwaj, Ma’an Amad, Lee Fader, Youla S. Tsantrizos, Richard Bethell, Christiane Yoakim, Steven R. LaPlante, Paul J. Edwards, Ted Halmos, Craig Fenwick
Publikováno v:
ACS Medicinal Chemistry Letters. 5:422-427
An assay recapitulating the 3' processing activity of HIV-1 integrase (IN) was used to screen the Boehringer Ingelheim compound collection. Hit-to-lead and lead optimization beginning with compound 1 established the importance of the C3 and C4 substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bbe9a8b0f8d3640b1a6a0a1c772694
https://doi.org/10.1021/ml500002n
https://doi.org/10.1021/ml500002n
Autor:
Marc-André Poupart, Peter W. White, Ghiro Elise, Nathalie Goudreau, Josée Bordeleau, Julie Naud, Yves Bousquet, Montse Llinas-Brunet, Michel Garneau, Sylvie Goulet, Pat Forgione, Jiamin Duan, Vida Gorys, Stephen H. Kawai, Michael Bös, Punit Bhardwaj, Ted Halmos, Murray D. Bailey, Michael G. Cordingley
Publikováno v:
Journal of Medicinal Chemistry. 53:6466-6476
C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported. A novel series of linear tripeptide inhibitors that are very potent and selective against the NS3 protease are described. A substantial contribution to the potency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467d82e582c5aba3804c154a35fc7443
https://doi.org/10.1021/jm100690x
https://doi.org/10.1021/jm100690x
Autor:
Marc-André Poupart, James Gillard, Pierre L. Beaulieu, George Kukolj, Sylvie Goulet, Martin Poirier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:196-200
Previously described SAR of benzimidazole-based non-nucleoside finger loop (Thumb Pocket I) inhibitors of HCV NS5B polymerase was expanded. Prospecting studies using parallel synthesis techniques allowed the rapid identification of novel cinnamic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a59e8deb716b1bed9b12c0d5a4ff4a
https://doi.org/10.1016/j.bmcl.2009.10.136
https://doi.org/10.1016/j.bmcl.2009.10.136
Autor:
Gulrez Fazal, Sylvie Goulet, Volkhard Austel, Jean Gauthier, Charles Pellerin, Pierre L. Beaulieu, Steven R. LaPlante, Ginette McKercher, Marc-André Poupart, James Gillard, George Kukolj, Michael Bös, Yves Bousquet, Sylvain Lefebvre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:119-124
Benzimidazole 5-carboxamide derivatives from a combinatorial screening library were discovered as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV). Initial hit-to-lead activities taking advantage of high-throughput parallel s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028cfd5fc70618a023732b6e8babde38
https://doi.org/10.1016/j.bmcl.2003.10.023
https://doi.org/10.1016/j.bmcl.2003.10.023
Autor:
Bruno Simoneau, Nathalie Goudreau, Steven M. Weldon, Mireille Cartier, Marc-André Poupart, Jean Rancourt, Gerhard G. Steinmann, Pierre R. Bonneau, Roger St. George, Chan-Loi Yong, Gordon Bolger, Murray D. Bailey, Lisette Lagacé, Anne-Marie Faucher, Daniel Lamarre, Michael G. Cordingley, Roel E. Sentjens, Pierre L. Beaulieu, Diane Thibeault, Hans Narjes, Youla S. Tsantrizos, Steven R. LaPlante, Stephen H. Kawai, Paul C. Anderson, Montse Llinas-Brunet, Michael Bös, Dale R. Cameron, George Kukolj
Publikováno v:
Nature. 426:186-189
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at risk of developing significant morbidity and mortality. Current interferon-based therapies are suboptimal espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902f0bd866b6ac0c922194d7ff8eaa72
https://doi.org/10.1038/nature02099
https://doi.org/10.1038/nature02099
Autor:
Marc-André Poupart, Ghiro Elise, Youla S. Tsantrizos, Nathalie Goudreau, Catherine Chabot, Dale R. Cameron, Sylvie Goulet, Martin Poirier
Publikováno v:
The Journal of Organic Chemistry. 66:4743-4751
The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473739bf769bbc95d91cb6db04354c13
https://doi.org/10.1021/jo010164d
https://doi.org/10.1021/jo010164d