Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway

Autor: Yu Guo, Minjie Shen, Qiping Dong, Natasha M. Méndez-Albelo, Sabrina X. Huang, Carissa L. Sirois, Jonathan Le, Meng Li, Ezra D. Jarzembowski, Keegan A. Schoeller, Michael E. Stockton, Vanessa L. Horner, André M. M. Sousa, Yu Gao, Birth Defects Research Laboratory, Jon E. Levine, Daifeng Wang, Qiang Chang, Xinyu Zhao

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the brain. The contribution of these targets to fragile X syndrome (FXS) and related autism spectrum disorder (ASD) remains unclear. Here, we show that FMRP de

Externí odkaz: https://doaj.org/article/c712033063bc4873a8e01bd8ebf89faa

Human-specific features and developmental dynamics of the brain N-glycome

Autor: Thomas S. Klarić, Ivan Gudelj, Gabriel Santpere, André M. M. Sousa, Mislav Novokmet, Frano Vučković, Shaojie Ma, Ivona Bečeheli, Chet C. Sherwood, John J. Ely, Patrick R. Hof, Djuro Josić, Gordan Lauc, Nenad Sestan

Publikováno v: bioRxiv

Comparative “omics” studies have revealed unique aspects of human neurobiology, yet an evolutionary perspective of the brain N-glycome is lacking. Here, we performed multi-regional characterization of rat, macaque, chimpanzee, and human brain N-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88a87dcaf48198d9600addc00f3171a
https://doi.org/10.1101/2023.01.11.523525

Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Autor: Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle

Publikováno v: Nat Neurosci
Nature neuroscience 25(4), 458-473 (2022). doi:10.1038/s41593-022-01043-3

Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the leading reason for brain surgery in children despite considerable d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7188034c8e54b35384ea495840fb8d5
https://pubmed.ncbi.nlm.nih.gov/35379995

Restoration of brain circulation and cellular functions hours post-mortem

Autor: Yury M. Morozov, Zhen W. Zhuang, Stefano G. Daniele, Mihovil Pletikos, Mario Skarica, Stephen G. Waxman, Rafeed Alkawadri, Navjot Kaur, John Silbereis, Francesca Talpo, Nenad Sestan, Brian S. Tanaka, Zvonimir Vrselja, Stephen R. Latham, André M. M. Sousa, Zhao Liu, Albert J. Sinusas

Publikováno v: Nature. 568:336-343

The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::294ff2765dab87cda1f2215a99b1fdf6
https://doi.org/10.1038/s41586-019-1099-1

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

Autor: M. Arfan Ikram, Lukas Pirpamer, Daniel E. Vosberg, Edith Hofer, David Ames, Sandra van der Auwera-Palitschka, Zdenka Pausova, Xueqiu Jian, Henry Brodaty, André M. M. Sousa, Linda Ding, Tavia E. Evans, William S. Kremen, Jean Shin, Steven Tilley, Fabrice Crivello, Christophe Tzourio, Karen A. Mather, Peter R. Schofield, Joanna M. Wardlaw, Joshua C. Bis, Tomáš Paus, Bernard Mazoyer, Myriam Fornage, Thomas H. Mosley, Natalie Terzikhan, Nathan A. Gillespie, Hans J. Grabe, Michelle Luciano, Mathew A. Harris, Nenad Sestan, Wei Wen, Sherif Karama, Reinhold Schmidt, Shaojie Ma, Katharina Wittfeld, Lindsay B. Lewis, Arno Villringer, Hieab H.H. Adams, Sudha Seshadri, Neda Jahanshad, Jiyang Jiang, Sophie Maingault, Yasaman Saba, Qiong Yang, Frauke Beyer, Stéphanie Debette, Nicola J. Armstrong, Markus Scholz, Carol E. Franz, Margaret J. Wright, Shuo Li, Rebecca F. Gottesman, Aniket Mishra, Perminder S. Sachdev, Yash Patel, John B.J. Kwok, Anbupalam Thalamuthu, Helena Schmidt, Amaia Carrion-Castillo, Robin Bülow, Mark E. Bastin, Markus Loeffler, Ian E. Deary, Stefan Frenzel, Julian N. Trollor, Gennady V. Roshchupkin, A. Veronica Witte

Publikováno v: Cerebral Cortex, 30(7), 4121-4139. Oxford University Press
Cerebral cortex 30(7), 4121-4139 (2020). doi:10.1093/cercor/bhaa035
Cerebral Cortex
2020, ' Global and regional development of the human cerebral cortex : Molecular architecture and occupational aptitudes ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhaa035
Cereb Cortex

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d226f09a8b9d01d3a3ad18d33554ba1
https://pure.eur.nl/en/publications/72d5930b-a0bc-44d8-8d56-fd3f2f98dfc8