Výsledky vyhledávání - "André L.A. Dos-Santos"

Innate immunomodulation to trypanosomatid parasite infections

Autor: Luiz Fernando Carvalho-Kelly, José Roberto Meyer-Fernandes, André L.A. Dos-Santos, Claudia F. Dick

Publikováno v: Experimental Parasitology. 167:67-75

The recognition of invading pathogens by the innate immune system is essential for host protection against human parasites and the initiation of an effective adaptive immune response. Innate immune cells such as macrophages and dendritic cells (DCs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007ca6d4bc10297e2ffa960f0eee6263
https://doi.org/10.1016/j.exppara.2016.05.005

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Cloning, expression and purification of 3'-nucleotidase/nuclease, an enzyme responsible for the Leishmania escape from neutrophil extracellular traps

Autor: Natalia C. Rochael, Michelle T. C. Nascimento, Elvira M. Saraiva, Claudia F. Dick, José Roberto Meyer-Fernandes, André L.A. Dos-Santos, Anita Leocadio Freitas-Mesquita

Publikováno v: Molecular and biochemical parasitology. 229

Leishmaniasis is one of the most significant of the neglected tropical diseases, with 350 million people in 98 countries worldwide living at risk of developing one of the many forms of the disease. During the transmission of the parasite from its vec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95e9db8a57580a2830b5f0858afe9dc
https://pubmed.ncbi.nlm.nih.gov/30772424

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Ectophosphatase activity in the early-diverging fungus Blastocladiella emersonii: Biochemical characterization and possible role on cell differentiation

Autor: José Roberto Meyer-Fernandes, Dayana K.B.B. Zamboni, Claudia F. Dick, Lisvane Paes-Vieira, André L.A. Dos-Santos, André Luiz Gomes-Vieira

Publikováno v: Fungal genetics and biology : FGB. 117

Blastocladiella emersonii is an interesting model for studding the evolution of cell differentiation in eukaryotic cell because of its taxonomic position towards the base of the fungal phylogenetic tree and because it undergoes radical morphological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a963c48d4672a6be3709e0422c37345a
https://pubmed.ncbi.nlm.nih.gov/30030178

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Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria

Autor: Kun Connie Liu, Mohammad Ali Oshaghi, Peter Agre, Wei Huang, Sibao Wang, Ge Wei, André L.A. Dos-Santos, Marcelo Jacobs-Lorena

Publikováno v: Science

Getting to the guts of mosquito control Malaria persistently evades our best efforts to eliminate it. Pike et al. genetically modified malaria vector mosquitoes to be more immune-resistant to infection by the parasite, which altered the composition o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913e7b77a70c6e10d5d14853a5092b68
https://europepmc.org/articles/PMC9793889/

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Inorganic phosphate uptake in unicellular eukaryotes

Autor: André L.A. Dos-Santos, Claudia F. Dick, José Roberto Meyer-Fernandes

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:2123-2127

Background Inorganic phosphate (Pi) is an essential nutrient for all organisms. The route of Pi utilization begins with Pi transport across the plasma membrane. Scope of review Here, we analyzed the gene sequences and compared the biochemical profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d332874cb7f1020ac6d80b5f21e338a
https://doi.org/10.1016/j.bbagen.2014.03.014

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Tartrate-resistant phosphatase type 5 in Trypanosoma cruzi is important for resistance to oxidative stress promoted by hydrogen peroxide

Autor: Claudia F. Dick, José Roberto Meyer-Fernandes, Adalberto Vieyra, Lisvane Paes-Vieira, Anita L. Freitas-Mesquita, André L.A. Dos-Santos, Humberto Muzi-Filho, Leandro R. Lopes, Nathália Rocco-Machado

Publikováno v: Experimental Parasitology. 205:107748

Trypanosoma cruzi (the causative agent of Chagas disease) presents a complex life cycle that involves adaptations in vertebrate and invertebrate hosts. As a protozoan parasite of hematophagous insects and mammalian hosts, T. cruzi is exposed to react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1580a0a7716f108774a05bbf2d1987
https://doi.org/10.1016/j.exppara.2019.107748

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Trypanosoma rangeli: An alkaline ecto-phosphatase activity is involved with survival and growth of the parasite

Autor: Claudia F. Dick, André L.A. Dos-Santos, José Roberto Meyer-Fernandes, André Luiz Fonseca-de-Souza, Thaís S. Silveira

Publikováno v: Experimental Parasitology. 135:459-465

The aim of this work was to investigate whether an alkaline ecto-phosphatase activity is present in the surface of Trypanosoma rangeli. Intact short epimastigote forms were assayed for ecto-phosphatase activity to study kinetics and modulators using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe8dfce374bb3a7ae8493743c646cb0
https://doi.org/10.1016/j.exppara.2013.08.014

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Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K(+) cycling and to active Na(+) extrusion

Autor: Katia C. Gondim, Naira Ligia Lima Giarola, Adalberto Vieyra, Claudia F. Dick, André L.A. Dos-Santos, José Roberto Meyer-Fernandes, L.S. Paes, David Majerowicz

Publikováno v: Biochimica et biophysica acta. 1830(8)

Background Orthophosphate (Pi) is a central compound in the metabolism of all organisms, including parasites. There are no reports regarding the mechanisms of Pi acquisition by Trypanosoma cruzi. Methods 32Pi influx was measured in T. cruzi epimastig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4e78441ba0de12f15a9bb08f6b0070
https://pubmed.ncbi.nlm.nih.gov/23643965

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Interaction between Trypanosoma rangeli and the Rhodnius prolixus salivary gland depends on the phosphotyrosine ecto-phosphatase activity of the parasite

Autor: Katia C. Gondim, José Roberto Meyer-Fernandes, Claudia F. Dick, Thaís S. Silveira, Michele Alves-Bezerra, Lisvane Silva Paes, André L.A. Dos-Santos

Publikováno v: International journal for parasitology. 42(9)

Trypanosoma rangeli is the trypanosomatid that colonizes the salivary gland of its insect vector, with a profound impact on the feeding capacity of the insect. In this study we investigated the role of the phosphotyrosine (P-Tyr) ecto-phosphatase act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe63b5058e747720efd881fbd06bf7
https://pubmed.ncbi.nlm.nih.gov/22749957

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Na+-dependent and Na+-independent mechanisms for inorganic phosphate uptake in Trypanosoma rangeli

Autor: I.V. Silva, Claudia F. Dick, José Roberto Meyer-Fernandes, Katia C. Gondim, Adalberto Vieyra, Celso Caruso-Neves, André L.A. Dos-Santos, David Majerowicz

Publikováno v: Biochimica et biophysica acta. 1820(7)

Background Trypanosoma rangeli is dependent on the presence of exogenous orthophosphate (Pi) for maximal growth and ecto-phosphatase activity is responsible for Pi supply under low Pi. Here we investigated the mechanisms of Pi uptake. Methods We inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561697e76504e0687abf51b55093129d
https://pubmed.ncbi.nlm.nih.gov/22456227

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