Zobrazeno 1 - 9
of 9
pro vyhledávání: '"André Kriegler"'
Publikováno v:
Biochemical Pharmacology. 45:2389-2397
Ulcerogenesis of the gastroduodenal mucosa is caused by the digestive action of gastric juice and initially involves an inflammatory reaction with infiltration of phagocytes. The anti-inflammatory activity of many drugs have been attributed to the in
Publikováno v:
International Journal of Biochemistry. 24:929-935
1. 1. Inhibition of myeloperoxidase (MPO)-catalyzed reactions by methyl-substituted xanthines has been investigated. 2. 2. Except for theobromine and caffeine, all xanthines tested were potent inhibitors of the MPO-H 2 O 2 -Cl − system. 3. 3. In co
Publikováno v:
Biochemical Pharmacology. 42:599-608
The mechanisms by which two anti-leprotic drugs (clofazimine and dapsone), both with anti-inflammatory properties, inhibit myeloperoxidase (MPO)-catalysed reactions, were investigated. The disappearance of NADH fluorescence was used as an assay for i
Publikováno v:
Toxicology. 68:37-49
The effects of two catechols (1,2-benzenediol and nordihydroguaiaretic acid) on the myeloperoxidase-Cl(-)-H2O2 antimicrobial/cytotoxic system of the human neutrophil were investigated. To determine the cytotoxicity of myeloperoxidase-generated oxygen
Publikováno v:
Biochemical Pharmacology. 40:947-954
The univalent oxidation of chlorpromazine (CPZ) by the myeloperoxidase (MPO-H2O2 system led to the formation of a cation free radical (CPZ+) which was observed optically at 527 nm. CPZ protected MPO against loss of catalytic activity when co-oxidized
Publikováno v:
The International journal of biochemistry. 26(9)
1. 1. Superoxide was generated during the auto-oxidation of the antituberculous drug, isonicotinic acid hydrazide (INH), but not with its meta-isomer, nicotinic acid hydrazide (NH). During Fe2+-stimulated oxidation of INH and NH, aromatic hydroxylati
Publikováno v:
Biochemical pharmacology. 47(6)
Benzoic acid was found to be hydroxylated by a mixture of myeloperoxidase (MPO) and the mycobactericidal drug, isoniazid. Aromatic hydroxylation and formation of compound III (oxyperoxidase) were coincident during the MPO-oxidase oxidation of isoniaz
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 25(11)
Thyroxine and other iodothyronines (concentrations in the nanomolar range) stimulated the oxidation of NADH in the myeloperoxidase-H2O2-Cl- system. In the absence of chloride, thyroxine had only a marginal effect. This suggests that thyroxine increas
Publikováno v:
European Journal of Pharmacology. 183:1365