Zobrazeno 1 - 10
of 15
pro vyhledávání: '"André Horatscheck"'
Autor:
Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L. Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazaré, Volker Haucke
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morpholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2f007efebfff9a9b182e223cbec7b
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Autor:
Claire, Le Manach, Jean, Dam, John G, Woodland, Gurminder, Kaur, Lutete P, Khonde, Christel, Brunschwig, Mathew, Njoroge, Kathryn J, Wicht, André, Horatscheck, Tanya, Paquet, Grant A, Boyle, Liezl, Gibhard, Dale, Taylor, Nina, Lawrence, Tomas, Yeo, Sachel, Mok, Richard T, Eastman, Dorjbal, Dorjsuren, Daniel C, Talley, Hui, Guo, Anton, Simeonov, Janette, Reader, Mariëtte, van der Watt, Erica, Erlank, Nelius, Venter, Jacek W, Zawada, Ayesha, Aswat, Luisa, Nardini, Theresa L, Coetzer, Sonja B, Lauterbach, Belinda C, Bezuidenhout, Anjo, Theron, Dalu, Mancama, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Sergio, Wittlin, Michael, Delves, Sabine, Ottilie, Elizabeth A, Winzeler, Thomas W, von Geldern, Dennis, Smith, David A, Fidock, Leslie J, Street, Gregory S, Basarab, James, Duffy, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(4)
A novel diazaspiro[3.4]octane series was identified from a
Autor:
Sabine Ottilie, Dale Taylor, Mariëtte van der Watt, Phanankosi Moyo, Lizette L. Koekemoer, Claire Le Manach, Daniel Opperman, James Duffy, Erica Erlank, Kelly Chibale, Sonja B Lauterbach, Lyn-Marie Birkholtz, Daniel E. Goldberg, Nimisha Mittal, Jessica I. Connacher, Lindsey M. Orchard, Ashleigh van Heerden, Natalie J. Spillman, Theresa L. Coetzer, Gregory S. Basarab, André Horatscheck, David Calvo, Elizabeth A. Winzeler, Anjo Theron, Janette Reader, Dalu Mancama, Nelius Venter, Grant A. Boyle, Eva S. Istvan, Manuel Llinás, Belinda C. Bezuidenhout, Luisa Nardini, Anne N. Cowell
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodiu
Autor:
Jean Dam, Keletso Maepa, Lutete Peguy Khonde, Claire Le Manach, Janette Reader, Mariëtte van der Watt, Gregory S. Basarab, Sergio Wittlin, John Okombo, Kathryn J. Wicht, James Duffy, Aloysius T. Nchinda, Dale Taylor, André Horatscheck, Mathew Njoroge, Christel Brunschwig, Timothy J. Egan, Nina Lawrence, Ana Carolina C. de Sousa, Leslie J. Street, Kelly Chibale, Lyn-Marie Birkholtz, Ana Andrijevic, Liezl Gibhard, Tanya Paquet, Kailash P. Pawar, Paul V. Fish
Publikováno v:
J Med Chem
A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f65b29b16b46e7c416d1fc66f6377
https://europepmc.org/articles/PMC7756195/
https://europepmc.org/articles/PMC7756195/
Autor:
Sabine Ottilie, Belinda C. Bezuidenhout, Claire Le Manach, Sonja B Lauterbach, Grant A. Boyle, Dale Taylor, Mariёtte E. van der Watt, James Duffy, Janette Reader, Kelly Chibale, Gregory S. Basarab, Luisa Nardini, David Calvo, Erica Erlank, Theresa L. Coetzer, Dalu Mancama, Nimisha Mittal, Elizabeth A. Winzeler, Phanankosi Moyo, Nelius Venter, Lizette L. Koekemoer, Lyn-Marie Birkholtz, André Horatscheck, Anjo Theron, Ashleigh van Heerden
New chemical matter is needed to target the divergent biology associated with the different life cycle stages ofPlasmodium. Here, we report the parallel screening of the Medicines for Malaria Venture Pandemic Response Box to identify multistage-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b62554483139943f425434f420265a7
https://doi.org/10.1101/2020.06.05.133405
https://doi.org/10.1101/2020.06.05.133405
Autor:
André Horatscheck, Ana Andrijevic, Aloysius T. Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C. de Sousa, John Okombo, Keletso Maepa, Timothy J. Egan, Lyn-Marie Birkholtz, Gregory S. Basarab, Sergio Wittlin, Paul V. Fish, Leslie J. Street, James Duffy, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 64:1762-1762
Autor:
Ngoc Chau, Phillip J. Robinson, Wiebke Stahlschmidt, Jennifer R. Baker, Adam McCluskey, Ainslie Whiting, Volker Haucke, Mark J. Robertson, Lisa von Kleist, Marc Nazaré, André Horatscheck, Samantha Sauer
Publikováno v:
Organic & Biomolecular Chemistry. 14:11266-11278
The development of a (Z)-5-((6,8-dichloro-4-oxo-4H-chromen-3-yl)methylene)-2-thioxothiazolidin-4-one (2), rhodanine-based lead that led to the Pitstop® 2 family of clathrin inhibitors is described herein. Head group substitution and bioisosteric rep
Autor:
Diego González, Cabrera, André, Horatscheck, Colin R, Wilson, Greg, Basarab, Charles J, Eyermann, Kelly, Chibale
Publikováno v:
Journal of Medicinal Chemistry
Advances in the genetics, function, and stage-specificity of Plasmodium kinases has driven robust efforts to identify targets for the design of antimalarial therapies. Reverse genomics following phenotypic screening against Plasmodia or related paras
Autor:
André Horatscheck, Vera Martos, Peter Schmieder, Dieter Lentz, Max Peter Bartetzko, Ulrike Uhrig, Han Sun, Marc Nazaré
Publikováno v:
Angewandte Chemie (International ed. in English). 56(23)
We dissected halogen–aryl π interactions experimentally using a bicyclic N-arylimide based molecular torsion balances system, which is based on the influence of the non-bonded interaction on the equilibria between folded and unfolded states. Throu