Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

Autor: Magdalena Cal-Bąkowska, Peter L. Pedersen, Daria Augustyniak, André Goffeau, Katarzyna Niedźwiecka, Mariusz Dyląg, Young Hee Ko, Stanisław Ułaszewski, Grazyna Majkowska-Skrobek

Publikováno v: Oncotarget

// Katarzyna Niedźwiecka 1 , Mariusz Dyląg 1, * , Daria Augustyniak 2 , Grazyna Majkowska-Skrobek 2 , Magdalena Cal-Bąkowska 1 , Young H. Ko 3 , Peter L. Pedersen 4 , Andre Goffeau 5 , Stanislaw Ulaszewski 1, * 1 Department of Genetics,Institute o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f9d6839e63d61c17edcddf4e700da4
http://europepmc.org/articles/PMC5323179

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Autor: João Azevedo-Silva, Stanisław Ułaszewski, Ana Preto, Peter L. Pedersen, Margarida Casal, Young Hee Ko, André Goffeau, Odília Queirós, Fátima Baltazar

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

At the beginning of the twenty-first century, 3-bromopyruvate (3BP), a simple alkylating chemical compound was presented to the scientific community as a potent anticancer agent, able to cause rapid toxicity to cancer cells without bystander effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d47ee434d92a42121164e1acd71ac2
https://hdl.handle.net/1822/45108

Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae

Autor: Stanisław Ułaszewski, Iwona Sobczak, Grzegorz Bartosz, Tomasz Bocer, Donata Wawrzycka, André Goffeau

Publikováno v: FEMS Yeast Research. 10:828-838

The Saccharomyces cerevisiae Yhl035p/Vmr1p is an ABC transporter of the MRP subfamily that is conserved in all post Whole Genome Duplication species. The deletion of the YHL035 gene caused growth sensitivity to several amphiphilic drugs such as cyclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dab5892dd196af97c22e749280cb1f44
https://doi.org/10.1111/j.1567-1364.2010.00673.x

Evolution of the carboxylate Jen transporters in fungi

Autor: André Goffeau, Julie Diffels, Philippe Baret, Tiziana Lodi

Publikováno v: FEMS Yeast Research. 7:646-656

Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemias

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3aba901eec6a864106f335d982526e
https://doi.org/10.1111/j.1567-1364.2007.00245.x

The Genome of the Kinetoplastid Parasite,Leishmania major

Autor: Kathy Seeger, G. Bothe, Rob Squares, Lee Murphy, Valentina Tosato, Michael A. Quail, Angela Lord, Alasdair Ivens, Christopher S. Peacock, Simon Rutter, Joel Rinta, Audrey Fraser, Dhileep Sivam, Carlo V. Bruschi, Nigel Fosker, Arlette Goble, Jenefer M. Blackwell, Silke Müller-Auer, K. Borzym, Robert L. Davies, Heather Munden, Holger Wedler, André Goffeau, Ellen Adlem, Christy Vogt, Susan O'Neil, David C. Schwartz, Siri Nelson, Bénédicte Purnelle, Angela K. Cruz, Martin Pentony, Deborah F. Smith, Michael A. Rieger, Laura Ciarloni, Kenneth Stuart, Marco A. Marra, Sven Klages, David L. Saunders, Alfred Beck, Marie-Adèle Rajandream, David Masuy, Andrew J Knights, Atashi Anupama, Karen Oliver, Helmut Hilbert, Rolf Wambutt, David Harris, Gabriella Bianchettin, Sarah Sharp, Nathalie Bason, Alberto C.C. Frasch, Matt Collins, Heesun Shin, Jeronimo C. Ruiz, Jeremy C. Mottram, David Horn, Richard M.R. Coulson, Elizabeth A. Worthey, Amber Seyler, Christopher Bauser, Natasha Larke, Bart Barrell, Ester Rabbinowitsch, John Woodward, Zina Apostolou, Christine Clayton, Christiane Hertz-Fowler, Ellen Sisk, Steve Squares, Gholam Fazelina, Laura Robertson, Johan Robben, T. Warren, Halina Norbertczak, Javier G. De Gaudenzi, Monika Fuchs, Shulamit Michaeli, Matthew Berriman, Claudia Gabel, Melanie Schäfer, Peter J. Myler, Thomas M. Pohl, Tin Louie, Rita Aert, Claire Price, Stephen M. Beverley, Guido Volckaert, Deborah E. Dobson, Richard Reinhardt, Lyudmila Litvin, Andreas Duesterhoeft, Ann Cronin, Jacquie Schein, Shiguo Zhou, Wolfgang Zimmermann, Gautam Aggarwal, Eithon Cadag, Yiting Huang, Michael Kube, Philip Attipoe, Keith R. Matthews

Publikováno v: Ivens, A C, Peacock, C S, Worthey, E A, Murphy, L, Aggarwal, G, Berriman, M, Sisk, E, Rajandream, M-A, Adlem, E, Aert, R, Anupama, A, Apostolou, Z, Attipoe, P, Bason, N, Bauser, C, Beck, A, Beverley, S M, Bianchettin, G, Borzym, K, Bothe, G, Bruschi, C V, Collins, M, Cadag, E, Ciarloni, L, Clayton, C, Coulson, R M R, Cronin, A, Cruz, A K, Davies, R M, De Gaudenzi, J, Dobson, D E, Duesterhoeft, A, Fazelina, G, Fosker, N, Frasch, A C, Fraser, A, Fuchs, M, Gabel, C, Goble, A, Goffeau, A, Harris, D, Hertz-Fowler, C, Hilbert, H, Horn, D, Huang, Y, Klages, S, Knights, A, Kube, M, Larke, N, Litvin, L, Lord, A, Louie, T, Marra, M, Masuy, D, Matthews, K, Michaeli, S, Mottram, J C, Müller-Auer, S, Munden, H, Nelson, S, Norbertczak, H, Oliver, K, O'neil, S, Pentony, M, Pohl, T M, Price, C, Purnelle, B, Quail, M A, Rabbinowitsch, E, Reinhardt, R, Rieger, M, Rinta, J, Robben, J, Robertson, L, Ruiz, J C, Rutter, S, Saunders, D, Schäfer, M, Schein, J, Schwartz, D C, Seeger, K, Seyler, A, Sharp, S, Shin, H, Sivam, D, Squares, R, Squares, S, Tosato, V, Vogt, C, Volckaert, G, Wambutt, R, Warren, T, Wedler, H, Woodward, J, Zhou, S, Zimmermann, W, Smith, D F, Blackwell, J M, Stuart, K D, Barrell, B & Myler, P J 2005, ' The genome of the kinetoplastid parasite, Leishmania major ', Science, vol. 309, no. 5733, pp. 436-42 . https://doi.org/10.1126/science.1112680

Leishmaniaspecies cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome ofLeishmania major(Friedlin strain) and predict 911 RNA genes, 39 pseudoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605efc1a4f8db0eb1ecd8e2397fa9e1a
https://doi.org/10.1126/science.1112680