Zobrazeno 1 - 10
of 65
pro vyhledávání: '"André Ex Brown"'
Autor:
Yinan Li, Anthony Osuma, Edgar Correa, Munachiso A Okebalama, Pauline Dao, Olivia Gaylord, Jihad Aburas, Priota Islam, André EX Brown, Paschalis Kratsios
Publikováno v:
eLife, Vol 9 (2020)
Terminal selectors are transcription factors (TFs) that establish during development and maintain throughout life post-mitotic neuronal identity. We previously showed that UNC-3/Ebf, the terminal selector of C. elegans cholinergic motor neurons (MNs)
Externí odkaz:
https://doaj.org/article/4cf25a9503344df1881291d600a054aa
Autor:
Weidong Feng, Yinan Li, Pauline Dao, Jihad Aburas, Priota Islam, Benayahu Elbaz, Anna Kolarzyk, André EX Brown, Paschalis Kratsios
Publikováno v:
eLife, Vol 9 (2020)
To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as expression of specific neurotransmitter receptors, ion channels and neuropeptides.
Externí odkaz:
https://doaj.org/article/e2e49c5767e149dcb7c2c67c4aadcaac
Publikováno v:
eLife, Vol 8 (2019)
In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is u
Externí odkaz:
https://doaj.org/article/09565fa0cb5a4d108a896d266fbaf27a
Autor:
Fen-Biao Gao, Evangelos Kiskinis, Jihad Aburas, Mark W. Kankel, Yuanzheng Gu, Tania F. Gendron, Yoshifumi Sonobe, Priota Islam, André Ex Brown, Raymond P. Roos, Paschalis Kratsios, Andrew C. Fleming, Gopinath Krishnan, Eleanor C. Warren, Ghanashyam D. Ghadge
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs) are synthesized from GGGGCC via r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd786bbdd341465cc73e0de3c49fe3cc
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa
Autor:
Fengqiu Diao, Irene Miguel-Aliaga, Pierre-Yves Plaçais, Dafni Hadjieconomou, Benjamin H. White, George King, Alex de Mendoza, Laura Blackie, Alessandro Mineo, Pedro Gaspar, Tomotsune Ameku, Chris Studd, André Ex Brown, Thomas Preat
Publikováno v:
Nature
Nature, Nature Publishing Group, 2020, 587 (7834), pp.455-459. ⟨10.1038/s41586-020-2866-8⟩
Nature, Nature Publishing Group, 2020, 587 (7834), pp.455-459. ⟨10.1038/s41586-020-2866-8⟩
Reproduction induces increased food intake across females of many animal species1–4, providing a physiologically relevant paradigm for the exploration of appetite regulation. Here, by examining the diversity of enteric neurons in Drosophila melanog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cf05a9fb30b3f8906f8278ab01c710
http://europepmc.org/articles/PMC7610780
http://europepmc.org/articles/PMC7610780
Autor:
Pratheeban Nambyiah, André Ex Brown
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Anaesthesia exposure to the developing nervous system causes neuroapoptosis and behavioural impairment in vertebrate models. Mechanistic understanding is limited, and target-based approaches are challenging. High-throughput methods may be an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b444a25a7a7ea53741e7c33050b1797
http://europepmc.org/articles/PMC8481492
http://europepmc.org/articles/PMC8481492
Autor:
Philippa H. Harlow, Ida Barlow, Anthony J. Flemming, Eleni Minga, Adam McDermott-Rouse, Luigi Feriani, André Ex Brown
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Novel invertebrate‐killing compounds are required in agriculture and medicine to overcome resistance to existing treatments. Because insecticides and anthelmintics are discovered in phenotypic screens, a crucial step in the discovery process is det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16dc9786347ba97b1db32dd53e9d9dd
Autor:
André Ex Brown, Pratheeban Nambyiah
BackgroundVertebrate animal experiments have suggested that anaesthesia exposure to the developing nervous system causes neuroapoptosis and behavioural impairment. Mechanistic understanding is limited, and target-based approaches are challenging. Hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1515be6858d1768f67e368fa8679e2f9
https://doi.org/10.1101/2020.10.28.358978
https://doi.org/10.1101/2020.10.28.358978
Autor:
Munachiso A Okebalama, Edgar Correa, Olivia Gaylord, Jihad Aburas, André Ex Brown, Yinan Li, Priota Islam, Pauline Dao, Paschalis Kratsios, Anthony Osuma
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Terminal selectors are transcription factors (TFs) that establish during development and maintain throughout life the identity of individual neuron types, but the underlying mechanisms remain poorly defined. Here, we use ChIP-Sequencing to globally i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d4e2b641d8e41e6ac6f4ecf59b03de
http://hdl.handle.net/10044/1/83864
http://hdl.handle.net/10044/1/83864
Autor:
Yinan Li, Munachiso A Okebalama, Edgar Correa, André Ex Brown, Jihad Aburas, Pauline Dao, Olivia Gaylord, Priota Islam, Paschalis Kratsios, Anthony Osuma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f471df35ee83ca73a2a97205611d12ac
https://doi.org/10.7554/elife.59464.sa2
https://doi.org/10.7554/elife.59464.sa2