Zobrazeno 1 - 10
of 17
pro vyhledávání: '"André E X, Brown"'
Autor:
Ida L. Barlow, Luigi Feriani, Eleni Minga, Adam McDermott-Rouse, Thomas James O’Brien, Ziwei Liu, Maximilian Hofbauer, John R. Stowers, Erik C. Andersen, Siyu Serena Ding, André E. X. Brown
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
A multiplexed machine-vision-based tracking system enables the high-content analysis of C. elegans behavior in several 96-well plates at a time and shows its utility for comparisons across multiple genotypes and upon drug treatment, tackling the bott
Externí odkaz:
https://doaj.org/article/c5ad7234fda74b00af76036124539bca
Autor:
Yoshifumi Sonobe, Jihad Aburas, Gopinath Krishnan, Andrew C. Fleming, Ghanashyam Ghadge, Priota Islam, Eleanor C. Warren, Yuanzheng Gu, Mark W. Kankel, André E. X. Brown, Evangelos Kiskinis, Tania F. Gendron, Fen-Biao Gao, Raymond P. Roos, Paschalis Kratsios
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A hexanucleotide repeat expansion of C9orf72 is translated to dipeptide repeat proteins in amyotrophic lateral sclerosis and frontotemporal dementia patients. Here the authors generate a C. elegans model of C9orf72-mediated ALS/FTD and show that tran
Externí odkaz:
https://doaj.org/article/05cc015c8b3f412d9f643d4bb372f4aa
Autor:
Holly Newton, Yi-Fang Wang, Laura Camplese, Joao B. Mokochinski, Holger B. Kramer, André E. X. Brown, Louise Fets, Susumu Hirabayashi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Cancer is a systemic disease that associates with host metabolic changes. Here, the authors show using Drosophila, that tumours exploit extracellular proline in response to muscle wasting, indicating that tumours induce muscle wasting as a nutrient-s
Externí odkaz:
https://doaj.org/article/0e28b218bcbf4e1a9a38907a77d327a9
Autor:
Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D. E. Greene, André E. X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.
Externí odkaz:
https://doaj.org/article/497f6a1f580e4f1db58b61849bc60df7
Autor:
Adam McDermott‐Rouse, Eleni Minga, Ida Barlow, Luigi Feriani, Philippa H Harlow, Anthony J Flemming, André E X Brown
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Abstract Novel invertebrate‐killing compounds are required in agriculture and medicine to overcome resistance to existing treatments. Because insecticides and anthelmintics are discovered in phenotypic screens, a crucial step in the discovery proce
Externí odkaz:
https://doaj.org/article/7f6f11a769624a6cac0239709f443cfd
Autor:
Filipe Marques, Saurabh Thapliyal, Avelino Javer, Priyanka Shrestha, André E X Brown, Dominique A Glauser
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009102 (2020)
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genom
Externí odkaz:
https://doaj.org/article/d05b23d9ef8440bcbd92d02c358da321
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1008002 (2020)
Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing remains challenging, even in simple model organisms. To measure the ageing process, we characterized the sequence of alterations of multiple phenotypes at org
Externí odkaz:
https://doaj.org/article/eea0ba3374a643178d22dd8a0638107b
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004322 (2015)
Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions would provide a basis for a comprehensive understanding of locomotor behaviour. Here we intro
Externí odkaz:
https://doaj.org/article/0294fae3f1d34cc78b8ce512065f77a8
Autor:
Yelena Koren, Raphael Sznitman, Paulo E Arratia, Christopher Carls, Predrag Krajacic, André E X Brown, Josué Sznitman
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122326 (2015)
To uncover the genetic basis of behavioral traits in the model organism C. elegans, a common strategy is to study locomotion defects in mutants. Despite efforts to introduce (semi-)automated phenotyping strategies, current methods overwhelmingly depe
Externí odkaz:
https://doaj.org/article/b4d20a5336214189937a274496bc6089
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1758)
Neuropeptide signalling has been implicated in a wide variety of biological processes in diverse organisms, from invertebrates to humans. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e5fc5955a7d04cbf042ea30a524f3c1
https://pubmed.ncbi.nlm.nih.gov/30201834
https://pubmed.ncbi.nlm.nih.gov/30201834