Zobrazeno 1 - 10
of 13
pro vyhledávání: '"André Boltjes"'
Publikováno v:
Synthesis (Germany), 53(11), 1980-1988. GEORG THIEME VERLAG KG
A series of tetrazole-linked dibenzo[b,f][1,4]oxazepines is synthesized through a short sequence involving an Ugi tetrazole reaction. The intermediate tetrazole undergoes a potassium carbonate mediated SNAr cyclization, followed by oxidation to affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c91820efde2867e8c15ddfe36982df
https://doi.org/10.1055/s-0040-1706642
https://doi.org/10.1055/s-0040-1706642
Autor:
Alexander Dömling, André Boltjes
Publikováno v:
European Journal of Organic Chemistry. 2019:7007-7049
Imidazo[1,2-a]pyridine is a well-known scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DS-1 and it also serves as a broadly applied pharmacophore in drug discovery. The scaffold revoked a wave of interest when Groeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c790fb4d855fe9353d9f13823041a588
https://doi.org/10.1002/ejoc.201901124
https://doi.org/10.1002/ejoc.201901124
Autor:
André, Boltjes, Alexander, Dömling
Publikováno v:
Eur J Chem
Imidazo[1,2-a]pyridine is a well-known scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DS-1 and it also serves as a broadly applied pharmacophore in drug discovery. The scaffold revoked a wave of interest when Groeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25aebb4465ddec0741235c45b6e6d62c
https://pubmed.ncbi.nlm.nih.gov/34012704
https://pubmed.ncbi.nlm.nih.gov/34012704
Autor:
André Boltjes
The research Andre Boltjes described in his thesis covers the application of MCR methodologies aimed at expansion of the scaffold library and implementation of these scaffolds for the development of pharmaceutical relevant, drug-like compounds and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf00b089871164f0e72b82bc365621d
https://research.rug.nl/en/publications/328c9b1a-a12e-4704-ba97-348fcc7a29a5
https://research.rug.nl/en/publications/328c9b1a-a12e-4704-ba97-348fcc7a29a5
Publikováno v:
Organic Syntheses
Organic syntheses, 94, 54-56
Organic syntheses, 94, 54-56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540351a69ad6d006fe80179b6f50917f
https://doi.org/10.15227/orgsyn.094.0054
https://doi.org/10.15227/orgsyn.094.0054
Autor:
Yijun Huang, Katarzyna Guzik, Alexander Dömling, James A. Gaugler, Siglinde Wolf, Katarzyna Lesniak, Laurie K. Rijkee, Tad A. Holak, André Boltjes, Rob van de Velde
Publikováno v:
Acs combinatorial science, 16(8), 393-396. AMER CHEMICAL SOC
ACS Combinatorial Science
ACS Combinatorial Science
On the basis of our recently resolved first cocrystal structure of Mdm4 in complex with a small molecule inhibitor (PDB ID 3LBJ ), we devised an approach for the generation of potential Mdm4 selective ligands. We performed the Ugi four-component reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b5c4d132f08fbe1da4c27103f4923e
https://hdl.handle.net/11370/d7ad75f2-b4c3-408e-8585-a49f246b92b6
https://hdl.handle.net/11370/d7ad75f2-b4c3-408e-8585-a49f246b92b6
Publikováno v:
MedChemCommun, 5(7), 949-952. ROYAL SOC CHEMISTRY
A three step synthesis of N-unsubstituted tetrazolo gamma- and delta-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ca480f12cf31c205e7469c366d8283
https://research.rug.nl/en/publications/4920deb7-ca1a-444c-9392-d425659499e3
https://research.rug.nl/en/publications/4920deb7-ca1a-444c-9392-d425659499e3
Publikováno v:
Tetrahedron Letters, 55(21), 3263-3266. PERGAMON-ELSEVIER SCIENCE LTD
Azido-Ugi reaction involving cyclic ketone, primary amine, isonitrile, and azide afforded substituted tetrazole derivatives 5. These intermediates were hydrolyzed to corresponding acid derivatives. EDAC/HOBt mediated amide bond formation of 5 gave fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45c4d3e5be5413b566afd26aa251dae
https://doi.org/10.1016/j.tetlet.2014.04.040
https://doi.org/10.1016/j.tetlet.2014.04.040
Publikováno v:
Chemistry – A European Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee8b30290133c5a556a1698660f0298
https://doi.org/10.1002/chem.201682261
https://doi.org/10.1002/chem.201682261