Zobrazeno 1 - 7
of 7
pro vyhledávání: '"André B. Farias"'
Publikováno v:
PeerJ, Vol 12, p e17069 (2024)
In this work we carried out an in silico analysis to understand the interaction between InvF-SicA and RNAP in the bacterium Salmonella Typhimurium strain LT2. Structural analysis of InvF allowed the identification of three possible potential cavities
Externí odkaz:
https://doaj.org/article/219985ceb6a84e6d9fc32b65dc4abd9f
Autor:
Iris S. Teixeira, André B. Farias, Bruno A. C. Horta, Humberto M. S. Milagre, Rodrigo O. M. A. de Souza, Uwe T. Bornscheuer, Cintia D. F. Milagre
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 777 (2022)
Amine transaminases (ATAs) are pyridoxal-5′-phosphate (PLP)-dependent enzymes that catalyze the transfer of an amino group from an amino donor to an aldehyde and/or ketone. In the past decade, the enzymatic reductive amination of prochiral ketones
Externí odkaz:
https://doaj.org/article/649e10cda30643599f8f4452f4c250e0
Autor:
Edson R. A. Oliveira, Laura Goracci, Bruno A. C. Horta, Lydia Siragusa, Graziâni Candiotto, André B. Farias, Gabriele Cruciani
Publikováno v:
New Journal of Chemistry
Non-structural protein 9 (Nsp9) plays a key role in viral replication of coronavirus and represents a promising target for anti-SARS-CoV-2 strategies. In order to find pockets with potential druggability, four binding-site search methods were employe
Autor:
Frederico Silva Castelo-Branco, André B. Farias, Evanoel Crizanto de Lima, Edson Roberto da Silva, Nubia Boechat, Claudia do Carmo Maquiaveli, Magdalena N. Rennó
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:3853-3859
Searching for new substances with antileishmanial activity, we synthesized and evaluated a series of α,α-difluorohydrazide and α,α-difluoramides against Leishmania amazonensis arginase (LaArg). Four α,α-difluorohydrazide derivatives showed acti
Autor:
Helga Gomes, Lupis Ribeiro, José Luciano Nepomuceno-Silva, Nelilma C. Romeiro, Jorge Moraes, Rodrigo Nunes da Fonseca, André B. Farias, Daniele Santos
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 247
DNA topoisomerase II enzymes maintain DNA stability during vital processes, such as genome replication, transcription and chromosomal segregation during mitosis and meiosis. In the present work, we analyzed functional aspects of the DNA topoisomerase
Autor:
Robson Xavier Faria, André Luis Almeida Souza, Noemi de Jesus Hiller, Daniela de Luna Martins, Nelilma C. Romeiro, André B. Farias, Nayane Abreu do Amaral e Silva, Jackson A. L. C. Resende
Publikováno v:
ChemMedChem. 13:1395-1404
Molecules containing an (cyanovinyl)arene moiety are known as tyrphostins because of their ability to inhibit proteins from the tyrosine kinase family, an interesting target for the development of anticancer and trypanocidal drugs. In the present wor
Autor:
Leandro L. da Silva, Daniela Corrêa Santos, Ruan R. Henriques, Marcos Antonio de Abreu Lopes Junior, André B. Farias, Andréa Luzia F. de Souza, Thayssa Lisboa do Couto Nogueira, Nelilma C. Romeiro, João Victor Fernandes Quimas
Publikováno v:
Bioorganicmedicinal chemistry. 28(10)
Acylhydrazones 1a-o, derived from isoniazid, were synthesized and evaluated for Myeloperoxidase (MPO) and Acetylcholinesterase (AChE) inhibition, as well as their antioxidant and metal chelating activities, with the purpose of investigating potential