The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer

Autor: Giulia Trimaglio, Tamara Sneperger, Benjamin B. A. Raymond, Nelly Gilles, Emmanuelle Näser, Marie Locard-Paulet, Marieke E. Ijsselsteijn, Thomas P. Brouwer, Romain Ecalard, Jessica Roelands, Naoki Matsumoto, André Colom, Myriam Habch, Noel F. C. C. de Miranda, Nathalie Vergnolle, Christel Devaud, Olivier Neyrolles, Yoann Rombouts

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the cellular and molecular interactions between immune cells and cancer cells has not only pr

Externí odkaz: https://doaj.org/article/f3225b2dcc7a4c39953c371ada897c96

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Autor: Rodolphe Dusaulcy, Chloé Rancoule, Sandra Grès, Estelle Wanecq, André Colom, Charlotte Guigné, Laurens A. van Meeteren, Wouter H. Moolenaar, Philippe Valet, Jean Sébastien Saulnier-Blache

Publikováno v: Journal of Lipid Research, Vol 52, Iss 6, Pp 1247-1255 (2011)

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific c

Externí odkaz: https://doaj.org/article/e5ac99397ff44ed8be0927e7dbf10e8b

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

Autor: Andre G. Loxton, Pablo Schierloh, Ingrid Mercier, Jan Rehwinkel, Brigitte Gicquel, Véronique Anton-Leberre, Talal Al-Saati, María del Carmen Sasiain, Anne O'Garra, Pierre Boudinot, Ludovic Tailleux, Olivier Neyrolles, Roland Lang, André Colom, Stefan H. E. Kaufmann, Simon Fillatreau, Alan Bénard, Denis Hudrisier, Luc Jouneau, Imme Sakwa

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2018, 197 (6), pp.801-813. ⟨10.1164/rccm.201707-1475OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2018, 197 (6), pp.801-813. ⟨10.1164/rccm.201707-1475OC⟩

In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or noninfectious diseases via antibody-independent mechanisms. In tuberculosis (TB), B cells accumulate in lungs, yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a7d5420c81e9442b1e50c85f8513aa
https://doi.org/10.1164/rccm.201707-1475oc

Periodontitis induced byPorphyromonas gingivalisdrives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

Autor: Pascale Klopp, Simon Nicolas, Matteo Serino, Pascale Loubieres, Rémy Burcelin, Céline Pomié, André Colom, Martine Bonnaure-Mallet, Vincent Blasco-Baque, Sandrine Le Gall-David, Vincent Azalbert, Mathieu Lemaitre, Quentin Escoula, Aurélie Waget, Lucile Garidou, Philippe Kémoun

Publikováno v: Gut
Gut, BMJ Publishing Group, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩
Gut, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩

International audience; OBJECTIVE: To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN: We set-up a unique animal model of periodontit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade10ab19bcbd38aa75d795c2ef7256a
https://doi.org/10.1136/gutjnl-2015-309897

Identification and characterization of lung commensal bacteria that modulate immune response in Tuberculosis

Autor: Lucie Bernard, André Colom, Margaux Cescato, Céline Cougoule, Pauline Guilloton, Natsinet Ghebrendrias, Florence Capilla, Annie Alloy, Aude Remot, Muriel Thomas, Philippe Langella, Olivier Neyrolles, Geanncarlo Lugo-Villarino

Publikováno v: The Journal of Immunology. 202:66.2-66.2

Tuberculosis (TB) is still one of the deadliest infectious diseases in humans. As TB disease is driven by exacerbation of the immune response, promising approaches include host-targeting therapies aiming at controlling the balance between pathogen er

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5054d71f0435c1f2548cb4aeae4cd343
https://doi.org/10.4049/jimmunol.202.supp.66.2