Zobrazeno 1 - 10
of 124
pro vyhledávání: '"André, Struglics"'
Autor:
Yun Deng, Thomas A Perry, Philippa Hulley, Rose A Maciewicz, Joanna Mitchelmore, Darryl Perry, Staffan Larsson, Sophie Brachat, André Struglics, C Thomas Appleton, Stefan Kluzek, Nigel K Arden, David Felson, Brian Marsden, Brian D M Tom, Laura Bondi, Mohit Kapoor, Vicky Batchelor, Jennifer Mackay-Alderson, Vinod Kumar, L Stefan Lohmander, Tim J Welting, David A Walsh, Ana M Valdes, STEpUP OA Consortium, Tonia L Vincent, Fiona E Watt, Luke Jostins-Dean
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0309677 (2024)
ObjectivesTo develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.MethodsSynovial Fluid To detect molecular Endotypes by Unbiased Proteomics in
Externí odkaz:
https://doaj.org/article/1a7b992e033f487392bdc5e67be7b7f1
Autor:
Elin Andersson, Emil Tykesson, L. Stefan Lohmander, Niclas G. Karlsson, Chunsheng Jin, Ekaterina Mirgorodskaya, Per Swärd, André Struglics
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 3, Pp 100380- (2023)
Objective: To validate a quantitative high performance liquid chromatography (HPLC) assay for chondroitin sulfate (CS) and hyaluronic acid (HA) in synovial fluid, and to analyze glycan-patterns in patient samples. Design: Synovial fluid from osteoart
Externí odkaz:
https://doaj.org/article/0855358b16f64dcda72abfe0193038b6
Autor:
Garima Dwivedi, Lisa Flaman, Begum Alaybeyoglu, André Struglics, Eliot H. Frank, Susan Chubinskya, Stephen B. Trippel, Vicki Rosen, Murat Cirit, Alan J. Grodzinsky
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) cocultur
Externí odkaz:
https://doaj.org/article/522239d893064200834c5e4152161f6f
Autor:
Eva-Lena Stattin, Karin Lindblom, André Struglics, Patrik Önnerfjord, Jack Goldblatt, Abhijit Dixit, Ajoy Sarkar, Tabitha Randell, Mohnish Suri, Cathleen Raggio, Jessica Davis, Erin Carter, Anders Aspberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The cartilage aggrecan proteoglycan is crucial for both skeletal growth and articular cartilage function. A number of aggrecan (ACAN) gene variants have been linked to skeletal disorders, ranging from short stature to severe chondrodyplasias
Externí odkaz:
https://doaj.org/article/1eb5bb77dab24e68b92ae2ffddd75753
Autor:
Oscar van derHave, Timothy J. Mead, Christian Westöö, Niccolò Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren‐Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran‐Lundmark
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrec
Externí odkaz:
https://doaj.org/article/9ec517eecbfa42948ac1c94d671fac5f
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 4, Pp 100307- (2022)
Objective: To determine biological variation of the aggrecanase-generated aggrecan ARGS neoepitope in serum (sARGS) and synovial fluid (sfARGS) within and between patients with osteoarthritis (OA) or anterior cruciate ligament (ACL) injury. Design: M
Externí odkaz:
https://doaj.org/article/95db0f1cfcda4c499540f3533d769457
Autor:
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Niclas G. Karlsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased
Externí odkaz:
https://doaj.org/article/6b701682bbad4a48b68b04253d62c085
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100293- (2022)
Externí odkaz:
https://doaj.org/article/39e788f1762941b691c9f52262bef2eb
Publikováno v:
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background To investigate if cartilage related biomarkers in synovial fluid are associated with knee cartilage status 20 years after an anterior cruciate ligament (ACL) injury. Methods We studied 25 patients with a complete ACL rupture witho
Externí odkaz:
https://doaj.org/article/41316f50c9904a04bbc9c4ee6399623c
Autor:
Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100191- (2021)
Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined the
Externí odkaz:
https://doaj.org/article/093224d3d1db4fb5b53c424d4fb42dd0