Zobrazeno 1 - 10
of 43
pro vyhledávání: '"André, Holdfeldt"'
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell specific genetic changes,
Externí odkaz:
https://doaj.org/article/12ec8eec840f487d88f7ff1809da12cb
Autor:
Qiao Liu, Martina Sundqvist, Wenyan Li, André Holdfeldt, Liang Zhang, Lena Björkman, Johan Bylund, Claes Dahlgren, Cai Wang, Xiaodong Zhao, Huamei Forsman
Publikováno v:
BMC Pediatrics, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Neutrophils and eosinophils are multifunctional granulocytes derived from common myelocytic-committed progenitor cells. Severe congenital neutropenia 1 (SCN1) caused by ELANE mutations is a rare disease characterized by very low n
Externí odkaz:
https://doaj.org/article/8543a9b84c97424ea9de327cf14ab1b0
Publikováno v:
Data in Brief, Vol 32, Iss , Pp 106185- (2020)
Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes. Signals generated by formyl peptide receptor 2 (FPR2) activate the neutrophil RO
Externí odkaz:
https://doaj.org/article/3fa53f7955f34f6f8f3749549e5f750b
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 411-414 (2016)
The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell
Externí odkaz:
https://doaj.org/article/06d48cf33d7047f3a4b47128e2885a98
Autor:
Malene Winther, André Holdfeldt, Martina Sundqvist, Zahra Rajabkhani, Michael Gabl, Johan Bylund, Claes Dahlgren, Huamei Forsman
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185132 (2017)
A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellular domains of the G-protein coupled receptor (GPCR) assumed to be the target. Neutrophils express two closely related formyl peptide receptors belong
Externí odkaz:
https://doaj.org/article/7431dc9a849244768e2109446e70f56d
Autor:
Lena Björkman, Huamei Forsman, Simon Lind, Michael Gabl, André Holdfeldt, Claes Dahlgren, Jonas Mårtensson, Martina Sundqvist
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Activation as well as recruitment of neutrophils, the most abundant leukocyte in human blood, to sites of infection/inflammation largely rely on surface-exposed chemoattractant receptors. These receptors belong to the family of 7-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92756b96888e4d7f6543243adf6aa92
https://doi.org/10.1021/acsptsci.0c00004
https://doi.org/10.1021/acsptsci.0c00004
Autor:
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, Henrik Franzyk, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Publikováno v:
Viklund, M, Fredriksson, J, Holdfeldt, A, Lind, S, Franzyk, H, Dahlgren, C, Sundqvist, M & Forsman, H 2022, ' Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation. ', Journal of Immunology, vol. 208, no. 7, pp. 1632-1641 . https://doi.org/10.4049/jimmunol.2101039
Highly pathogenic Staphylococcus aureus strains produce phenol-soluble modulins (PSMs), which are N-formylated peptides. Nanomolar concentrations of PSMα2 are recognized by formyl peptide receptor 2 (FPR2), but unlike the prototypic FPR2 agonist WKY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc31dfc803cc9843074697bd5c669423
https://curis.ku.dk/portal/da/publications/structural-determinants-in-the-staphylococcus-aureusderived-phenolsoluble-modulin-2-peptide-required-for-neutrophil-formyl-peptide-receptor-activation(40b1ceb3-fe3e-496d-8873-63dcb8601a41).html
https://curis.ku.dk/portal/da/publications/structural-determinants-in-the-staphylococcus-aureusderived-phenolsoluble-modulin-2-peptide-required-for-neutrophil-formyl-peptide-receptor-activation(40b1ceb3-fe3e-496d-8873-63dcb8601a41).html
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167529 (2016)
Two different immune recognition systems have evolved in parallel to recognize peptides starting with an N-formylated methionine, and recognition similarities/differences between these two systems have been investigated. A number of peptides earlier
Externí odkaz:
https://doaj.org/article/99cb0ea487684802a70d223cc704bb9c
Autor:
Johanna Fredriksson, André Holdfeldt, Jonas Mårtensson, Lena Björkman, Thor C. Møller, Erik Müllers, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Publikováno v:
Fredriksson, J, Holdfeldt, A, Mårtensson, J, Björkman, L, Møller, T C, Müllers, E, Dahlgren, C, Sundqvist, M & Forsman, H 2022, ' GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists ', Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1869, no. 7, 119262 . https://doi.org/10.1016/j.bbamcr.2022.119262
In order to avoid a prolonged pro-inflammatory neutrophil response, signaling downstream of an agonist-activated G protein-coupled receptor (GPCR) has to be rapidly terminated. Among the family of GPCR kinases (GRKs) that regulate receptor phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9325d3857279f1049bf84ea0cf4bb7ed
https://pubmed.ncbi.nlm.nih.gov/35341806
https://pubmed.ncbi.nlm.nih.gov/35341806
Autor:
Moa, Viklund, Johanna, Fredriksson, André, Holdfeldt, Simon, Lind, Henrik, Franzyk, Claes, Dahlgren, Martina, Sundqvist, Huamei, Forsman
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 208(7)
Highly pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fabae3729abfd8b4cad298232731fc9
https://pubmed.ncbi.nlm.nih.gov/35321878
https://pubmed.ncbi.nlm.nih.gov/35321878