Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus

Autor: Natália S. Wassano, Gabriela B. da Silva, Artur H. Reis, Jaqueline A. Gerhardt, Everton P. Antoniel, Daniel Akiyama, Caroline P. Rezende, Leandro X. Neves, Elton J. R. Vasconcelos, Fernanda L. de Figueiredo, Fausto Almeida, Patrícia A. de Castro, Camila F. Pinzan, Gustavo H. Goldman, Adriana F. Paes Leme, Taicia P. Fill, Nilmar S. Moretti, André Damasio

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)

Abstract Aspergillus fumigatus represents a public health problem due to the high mortality rate in immunosuppressed patients and the emergence of antifungal-resistant isolates. Protein acetylation is a crucial post-translational modification that co

Externí odkaz: https://doaj.org/article/e94c592492c34094b6c73563cbaa8160

Metabolic engineering of Saccharomyces cerevisiae for second-generation ethanol production from xylo-oligosaccharides and acetate

Autor: Dielle Pierotti Procópio, Jae Won Lee, Jonghyeok Shin, Robson Tramontina, Patrícia Felix Ávila, Lívia Beatriz Brenelli, Fabio Márcio Squina, André Damasio, Sarita Cândida Rabelo, Rosana Goldbeck, Telma Teixeira Franco, David Leak, Yong-Su Jin, Thiago Olitta Basso

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Simultaneous intracellular depolymerization of xylo-oligosaccharides (XOS) and acetate fermentation by engineered Saccharomyces cerevisiae offers significant potential for more cost-effective second-generation (2G) ethanol production. In the

Externí odkaz: https://doaj.org/article/6cdd9952b8cf4b409767b3362a53a0b7

A Timeline of Biosynthetic Gene Cluster Discovery in Aspergillus fumigatus: From Characterization to Future Perspectives

Autor: Hye-Won Seo, Natalia S. Wassano, Mira Syahfriena Amir Rawa, Grant R. Nickles, André Damasio, Nancy P. Keller

Publikováno v: Journal of Fungi, Vol 10, Iss 4, p 266 (2024)

In 1999, the first biosynthetic gene cluster (BGC), synthesizing the virulence factor DHN melanin, was characterized in Aspergillus fumigatus. Since then, 19 additional BGCs have been linked to specific secondary metabolites (SMs) in this species. He

Externí odkaz: https://doaj.org/article/9298e4330ecc476aad1f942a08c41b45

SARS-CoV-2 uses CD4 to infect T helper lymphocytes

Autor: Natalia S Brunetti, Gustavo G Davanzo, Diogo de Moraes, Allan JR Ferrari, Gabriela F Souza, Stéfanie Primon Muraro, Thiago L Knittel, Vinicius O Boldrini, Lauar B Monteiro, João Victor Virgílio-da-Silva, Gerson S Profeta, Natália S Wassano, Luana Nunes Santos, Victor C Carregari, Artur HS Dias, Flavio P Veras, Lucas A Tavares, Julia Forato, Icaro MS Castro, Lícia C Silva-Costa, André C Palma, Eli Mansour, Raisa G Ulaf, Ana F Bernardes, Thyago A Nunes, Luciana C Ribeiro, Marcus V Agrela, Maria Luiza Moretti, Lucas I Buscaratti, Fernanda Crunfli, Raissa G Ludwig, Jaqueline A Gerhardt, Natália Munhoz-Alves, Ana Maria Marques, Renata Sesti-Costa, Mariene R Amorim, Daniel A Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Karina Bispos-dos-Santos, Camila L Simeoni, Fabiana Granja, Virgínia C Silvestrini, Eduardo B de Oliveira, Vitor M Faca, Murilo Carvalho, Bianca G Castelucci, Alexandre B Pereira, Laís D Coimbra, Marieli MG Dias, Patricia B Rodrigues, Arilson Bernardo SP Gomes, Fabricio B Pereira, Leonilda MB Santos, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C Pontelli, Sean Whelan, Andrei C Sposito, Robson F Carvalho, André S Vieira, Marco AR Vinolo, André Damasio, Licio Velloso, Ana Carolina M Figueira, Luis LP da Silva, Thiago Mattar Cunha, Helder I Nakaya, Henrique Marques-Souza, Rafael E Marques, Daniel Martins-de-Souza, Munir S Skaf, Jose Luiz Proenca-Modena, Pedro MM Moraes-Vieira, Marcelo A Mori, Alessandro S Farias

Publikováno v: eLife, Vol 12 (2023)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related c

Externí odkaz: https://doaj.org/article/99a35dd8fb984baea7fc8271d68472e7

Improvement of homologous GH10 xylanase production by deletion of genes with predicted function in the Aspergillus nidulans secretion pathway

Autor: Mariane P. Zubieta, Jaqueline A. Gerhardt, Marcelo V. Rubio, César R. F. Terrasan, Gabriela F. Persinoti, Everton P. Antoniel, Fabiano J. Contesini, Rolf A. Prade, André Damasio

Publikováno v: Microbial Biotechnology, Vol 13, Iss 4, Pp 1245-1253 (2020)

Summary Filamentous fungi are important cell factories for large‐scale enzyme production. However, production levels are often low, and this limitation has stimulated research focusing on the manipulation of genes with predicted function in the pro

Externí odkaz: https://doaj.org/article/f9d977477ae947c8b8cb17b4c5e3e0fb