Zobrazeno 1 - 10
of 11
pro vyhledávání: '"András Varadi"'
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Akademický článek
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Autor:
Dávid Czimer, Klaudia Porok, Dániel Csete, Zsolt Gyüre, Viktória Lavró, Krisztina Fülöp, Zelin Chen, Hella Gyergyák, Gábor E. Tusnády, Shawn M. Burgess, Attila Mócsai, András Váradi, Máté Varga
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Calcification of various tissues is a significant health issue associated with aging, cancer and autoimmune diseases. There are both environmental and genetic factors behind this phenomenon and understanding them is essential for the development of e
Externí odkaz:
https://doaj.org/article/80400f731141453b9117c01d3381331a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228291 (2020)
Accumulation of lipofuscin bisretinoids in the retina contributes to pathogenesis of macular degeneration. Retinol-Binding Protein 4 (RBP4) antagonists reduce serum retinol concentrations thus partially reducing retinol delivery to the retina which d
Externí odkaz:
https://doaj.org/article/ae0d4bbb4c2f45a2bbeaccc247c1b2af
Autor:
Dóra Dedinszki, Flóra Szeri, Eszter Kozák, Viola Pomozi, Natália Tőkési, Tamás Róbert Mezei, Kinga Merczel, Emmanuel Letavernier, Ellie Tang, Olivier Le Saux, Tamás Arányi, Koen van de Wetering, András Váradi
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 11, Pp 1463-1470 (2017)
Abstract Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due
Externí odkaz:
https://doaj.org/article/dd5aa1b75e9b4bf692423b721ab030b0
Autor:
Ferenc Zádor, Amir Mohammadzadeh, Mihály Balogh, Zoltán S. Zádori, Kornél Király, Szilvia Barsi, Anna Rita Galambos, Szilvia B. László, Barbara Hutka, András Váradi, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Susanna Fürst, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 25, Iss 6, p 1370 (2020)
The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-s
Externí odkaz:
https://doaj.org/article/a3369a5ac33645918898849b78f5c94e
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205657 (2018)
Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range
Externí odkaz:
https://doaj.org/article/2f9932ccb55f4632af1ab8a39a583829
Publikováno v:
Molecules, Vol 21, Iss 1, p 19 (2015)
Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been in
Externí odkaz:
https://doaj.org/article/fac6e4f8d0704b3699668d5bf883d635
Autor:
Olivier Le Saux, Krisztina Fülöp, Yukiko Yamaguchi, Attila Iliás, Zalán Szabó, Christopher N Brampton, Viola Pomozi, Krisztina Huszár, Tamás Arányi, András Váradi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24738 (2011)
Loss-of-function mutations in ABCC6 can cause chronic or acute forms of dystrophic mineralization described in disease models such as pseudoxanthoma elasticum (OMIM 26480) in human and dystrophic cardiac calcification in mice. The ABCC6 protein is a
Externí odkaz:
https://doaj.org/article/4fabc2a6dc1d4003a1f0b2113ff92b9b