Zobrazeno 1 - 10
of 323
pro vyhledávání: '"András Guttman"'
Autor:
Csenge Filep, András Guttman
Publikováno v:
Analytical Chemistry. 94:13092-13099
The electromigration dispersion of the light- and heavy-chain subunit peaks of the therapeutic monoclonal antibody omalizumab was investigated in sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using borate cross-linked dextran sieving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dd7697c5ccd53b844a4dc254a1649a
https://doi.org/10.1021/acs.analchem.2c02348
https://doi.org/10.1021/acs.analchem.2c02348
Publikováno v:
ELECTROPHORESIS. 43:143-166
Capillary electrophoresis (CE), after being introduced several decades ago, has carved out a niche for itself in the field of analytical characterization of biopharmaceutical products. It does not only offer fast separation, high resolution in miniat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b518a90424aa2ac03208275dd1fb20fc
https://doi.org/10.1002/elps.202100182
https://doi.org/10.1002/elps.202100182
Publikováno v:
Analytical Chemistry. 93:9267-9276
Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques. Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75b1aaf8e6eba650fd6e2ae215dde4c
https://doi.org/10.1021/acs.analchem.1c01636
https://doi.org/10.1021/acs.analchem.1c01636
Publikováno v:
TrAC Trends in Analytical Chemistry. 162:117024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf5733698bb79f28c5fd10264b00a51
https://doi.org/10.1016/j.trac.2023.117024
https://doi.org/10.1016/j.trac.2023.117024
Autor:
Csenge Filep, András Guttman
Publikováno v:
Analytical Chemistry. 93:3535-3541
With the increasing interest in the biopharmaceutical industry toward novel and innovative protein therapeutics, improved separation techniques are important, especially for the analysis of highly glycosylated candidates. Sodium dodecyl sulfate capil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32d1b6b92d4e253d048dfa52ddf12e4
https://doi.org/10.1021/acs.analchem.0c04927
https://doi.org/10.1021/acs.analchem.0c04927
Autor:
András Guttman, Eszter Csánky, Miklós Szabó, Anna Farkas, Marton Szigeti, Brigitta Mészáros, János Kappelmayer, Máté Szarka
Publikováno v:
Current Molecular Medicine. 20:765-772
Background: Immunoglobulin G and A, transferrin, haptoglobin and alpha-1- antitrypsin represent approximately 85% of the human serum glycoproteome and their N-glycosylation analysis may lead to the discovery of important molecular disease markers. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e807b857824795b3054fbb45d23edd
https://doi.org/10.2174/1566524020666200422085316
https://doi.org/10.2174/1566524020666200422085316
Autor:
András Guttman, László Hajba
Publikováno v:
Current Molecular Medicine. 20:806-813
Adeno-associated virus (AAV) is one of the most promising viral gene delivery vectors with long-term gene expression and disease correction, featuring high efficiency and excellent safety in human clinical trials. During the production of AAV vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fbfc245914555cf9f21958d9bf7242
https://doi.org/10.2174/1566524020999200730181042
https://doi.org/10.2174/1566524020999200730181042
Publikováno v:
Current Molecular Medicine. 20:789-797
Aims: To demonstrate the capabilities of our new capillary electrophoresis – mass spectrometry method, which facilitates highly accurate relative quantitation of modification site occupancy of antibody-ligand (e.g., antibody-drug) conjugates. Backg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7533ad114030ae9b16aa5adf102429ad
https://doi.org/10.2174/1566524020666200415095830
https://doi.org/10.2174/1566524020666200415095830
Autor:
Zsuzsanna Molnár, Zsolt Ronai, Zsófia Bánlaki, András Guttman, Gergely Keszler, Magdolna Herold, Anikó Somogyi, Zoltán Herold
Publikováno v:
Current Molecular Medicine. 20:773-780
Background: Type 2 diabetes (T2DM) and colorectal cancer (CRC) are both known to modulate gene expression patterns in peripheral blood leukocytes (PBLs). Objective : As T2DM has been shown to increase the incidence of CRC, we were prompted to check w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce48ac532fbd8b0a092b087db73d9b45
https://doi.org/10.2174/1566524020666200504084626
https://doi.org/10.2174/1566524020666200504084626
Publikováno v:
Current Molecular Medicine. 20:798-805
Background: Plasmid DNA has been widely used in vaccination as well as in cell and gene therapy. It exists in multiple isoforms, including supercoiled, nicked or open circular and linear forms. Regulatory agencies recommend having more than 80% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c45cd2ed0c15fdc69b3894d14d73a75
https://doi.org/10.2174/1566524020666200427110452
https://doi.org/10.2174/1566524020666200427110452