Zobrazeno 1 - 10
of 17
pro vyhledávání: '"András, Visegrády"'
Autor:
Márta Thán, László Fodor, Amrita Bobok, György Szabó, György Túrós, András Visegrády, Rita Soukupné Kedves, Gábor Kapus
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S903- (2023)
Externí odkaz:
https://doaj.org/article/40f36b1a23c6485eac85502a1d3b8a28
Autor:
Béla Kiss, István Laszlovszky, Balázs Krámos, András Visegrády, Amrita Bobok, György Lévay, Balázs Lendvai, Viktor Román
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 104 (2021)
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS) and periphery, exerts its actions through five types of receptors which belong to two major subfamilies such as D1-like (i.e., D1 and D5 receptors) and D2-like (
Externí odkaz:
https://doaj.org/article/846d16b9649c42d3aa9e799b8e5abc4d
Autor:
María Isabel Loza, Rob Leurs, Chris de Graaf, András Visegrády, Attila Egyed, György M. Keserű, José Brea, Ádám Andor Kelemen, Stephanie A. Thee, Zhiyong Wang, Márton Vass
Publikováno v:
Bioorganic Chemistry, 111:104832, 1-11. Academic Press Inc.
Egyed, A, Kelemen, Á A, Vass, M, Visegrády, A, Thee, S A, Wang, Z, de Graaf, C, Brea, J, Loza, M I, Leurs, R & Keserű, G M 2021, ' Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule ', Bioorganic Chemistry, vol. 111, 104832, pp. 1-11 . https://doi.org/10.1016/j.bioorg.2021.104832
Egyed, A, Kelemen, Á A, Vass, M, Visegrády, A, Thee, S A, Wang, Z, de Graaf, C, Brea, J, Loza, M I, Leurs, R & Keserű, G M 2021, ' Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule ', Bioorganic Chemistry, vol. 111, 104832, pp. 1-11 . https://doi.org/10.1016/j.bioorg.2021.104832
In addition to the orthosteric binding pocket (OBP) of GPCRs, recent structural studies have revealed that there are several allosteric sites available for pharmacological intervention. The secondary binding pocket (SBP) of aminergic GPCRs is located
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05fe1ab8d56524eef48524ef62e088
https://doi.org/10.1016/j.bioorg.2021.104832
https://doi.org/10.1016/j.bioorg.2021.104832
Autor:
Istvan Laszlovszky, András Visegrády, Balázs Krámos, Viktor Román, Balázs Lendvai, Bela Kiss, Amrita Ágnes Bobok, György Lévay
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 104, p 104 (2021)
Biomolecules, Vol 11, Iss 104, p 104 (2021)
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS) and periphery, exerts its actions through five types of receptors which belong to two major subfamilies such as D1-like (i.e., D1 and D5 receptors) and D2-like (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de84aeafafed70255736933fb94c31f7
https://pubmed.ncbi.nlm.nih.gov/33466844
https://pubmed.ncbi.nlm.nih.gov/33466844
Autor:
Szilveszter, Nagygyőry, Mária, Wittmann, Szilveszter, Pintér, András, Visegrády, András, Dancsó, Nguyen Bich, Thuy, Zoltán, Noszticzius, László, Hegedüs, Horst-Dieter, Försterling
Publikováno v:
The journal of physical chemistry. A. 103(25)
The Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c13d7a0e3f47875f065fef8775669cd5
https://pubmed.ncbi.nlm.nih.gov/31995859
https://pubmed.ncbi.nlm.nih.gov/31995859
Autor:
Zsolt Némethy, Balázs Lendvai, Balázs Krámos, Katalin Dudás Molnár, Ottilia Balázs, Anita Horváth, Áron Szigetvári, György Lévay, János Kóti, János Éles, Istvan Vago, István Ledneczki, András Visegrády, Mónika Vastag, Marta Than, Pál Tapolcsányi, Diána Kostyalik, Sándor Mahó, Sándor Kolok, Patrik Holm, László Fodor, István Greiner, László Kiss
Publikováno v:
European Journal of Medicinal Chemistry. 222:113560
HTS campaign of the corporate compound collection resulted in a novel, oxalic acid diamide scaffold of α7 nACh receptor positive allosteric modulators. During the hit expansion, several derivatives, such as 4, 11, 17 demonstrated not only high in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25756ef61e702aa21bdd1b8a5b62e5bf
https://doi.org/10.1016/j.ejmech.2021.113560
https://doi.org/10.1016/j.ejmech.2021.113560
Autor:
Balázs Lendvai, Anna E. Káncz, Pál Tapolcsányi, Zoltán Béni, János Kóti, Marta Than, Éva Bozó, János Éles, István Greiner, Judit Laszy, Zsolt Némethy, Sándor Mahó, András Visegrády, Márton Vass, Gyula Bugovits, György Lévay, István Ledneczki, Anikó Pocsai, Balázs Krámos, Ágota Szájli, Mónika Vastag, Patrik Holm, Sándor Kolok, Eszter Gábor, Ottilia Balázs, Anita Horváth, József Nagy
Publikováno v:
European Journal of Medicinal Chemistry. 214:113189
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts were carried out to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad9ffda37f8a3d089c88187d8a3c0f
https://doi.org/10.1016/j.ejmech.2021.113189
https://doi.org/10.1016/j.ejmech.2021.113189
Publikováno v:
Analytical biochemistry. 566
Cell-based assays against cell surface receptor targets are essential in vitro models of target-based drug discovery. At the lead generation phase large-scale functional screening assays monitoring individual cellular readouts detect interactions bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d556596edc14eaa5af8c4f9e486ea45
https://pubmed.ncbi.nlm.nih.gov/30452893
https://pubmed.ncbi.nlm.nih.gov/30452893
Autor:
György M. Keserű, András Visegrády
Publikováno v:
Expert Opinion on Drug Discovery. 8:811-820
G-protein-coupled receptors (GPCRs) form one of the largest groups of potential targets for novel medications. Low druggability of many GPCR targets and inefficient sampling of chemical space in high-throughput screening expertise however often hinde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ef3be63ee7562396f4fbba0b68b1ee
https://doi.org/10.1517/17460441.2013.794135
https://doi.org/10.1517/17460441.2013.794135
Publikováno v:
Analytical biochemistry. 507
Cell-based assays for G-protein-coupled receptor (GPCR) activation applied in high-throughput screening (HTS) monitor various readouts for second messengers or intracellular effectors. Recently, our understanding of diverging signaling pathways downs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bdcd6add14be8ab13b181a5a4cf824
https://pubmed.ncbi.nlm.nih.gov/27235172
https://pubmed.ncbi.nlm.nih.gov/27235172