Zobrazeno 1 - 10
of 189
pro vyhledávání: '"András, Váradi"'
Autor:
Eszter Kozák, Jonas W. Bartstra, Pim A. de Jong, Willem P. T. M. Mali, Krisztina Fülöp, Natália Tőkési, Viola Pomozi, Sara Risseeuw, Jeannette Ossewaarde-van Norel, Redmer van Leeuwen, András Váradi, Wilko Spiering
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 3, p 1047 (2023)
Background: Pseudoxanthoma elasticum (PXE), a monogenic disorder resulting in calcification affecting the skin, eyes and peripheral arteries, is caused by mutations in the ABCC6 gene, and is associated with low plasma inorganic pyrophosphate (PPi). I
Externí odkaz:
https://doaj.org/article/12665b0a81ba4e89995edd9aa03ca3d6
Autor:
Dávid Czimer, Klaudia Porok, Dániel Csete, Zsolt Gyüre, Viktória Lavró, Krisztina Fülöp, Zelin Chen, Hella Gyergyák, Gábor E. Tusnády, Shawn M. Burgess, Attila Mócsai, András Váradi, Máté Varga
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Calcification of various tissues is a significant health issue associated with aging, cancer and autoimmune diseases. There are both environmental and genetic factors behind this phenomenon and understanding them is essential for the development of e
Externí odkaz:
https://doaj.org/article/80400f731141453b9117c01d3381331a
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Autor:
Ferenc Zádor, Amir Mohammadzadeh, Mihály Balogh, Zoltán S. Zádori, Kornél Király, Szilvia Barsi, Anna Rita Galambos, Szilvia B. László, Barbara Hutka, András Váradi, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Susanna Fürst, Mahmoud Al-Khrasani
Publikováno v:
Molecules, Vol 25, Iss 6, p 1370 (2020)
The present work represents the in vitro (potency, affinity, efficacy) and in vivo (antinociception, constipation) opioid pharmacology of the novel compound 14-methoxycodeine-6-O-sulfate (14-OMeC6SU), compared to the reference compounds codeine-6-O-s
Externí odkaz:
https://doaj.org/article/a3369a5ac33645918898849b78f5c94e
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205657 (2018)
Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range
Externí odkaz:
https://doaj.org/article/2f9932ccb55f4632af1ab8a39a583829
Autor:
András Váradi, László Kovács, Naomi Schlesinger, Gabriella Szücs, Qiaoli Li, Kathleen Aren, Eszter Kozák, Vivien Hsu, Isaac Goldberg, Márta Bocskai, John Varga, Scott T. McClure, Bálint Bálint László, Ann K. Rosenthal, Mary Carns, Szilvia Szamosi
Publikováno v:
Rheumatology (Oxford)
Objective The pathogenesis of calcinosis cutis, a disabling complication of SSc, is poorly understood and effective treatments are lacking. Inorganic pyrophosphate (PPi) is a key regulator of ectopic mineralization, and its deficiency has been implic
Autor:
Gábor E. Tusnády, György Várady, Dóra Dedinszki, András Váradi, Eszter Kozák, Bence Szikora, Natália Tőkési, Attila Iliás, Viola Pomozi, Zoltán Hegyi, Péter K. Jani, Éva Bakos, Krisztina Fülöp, Imre Kacskovics, Zsolt Matula
Publikováno v:
FEBS Letters. 595:789-798
Mutations in the ABCC6 gene result in calcification diseases such as pseudoxanthoma elasticum or Generalized Arterial Calcification of Infancy. Generation of antibodies recognizing an extracellular (EC) epitope of ABCC6 has been hampered by the short
Autor:
Parthasarathy Muthuraman, Boglarka Racz, Konstantin Petrukhin, Arun Raja, András Váradi, Christopher L. Cioffi
Publikováno v:
J Med Chem
Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all-trans-retinol (1) delivered via a tertiary retinol bind
Autor:
Ernst J Reichenberger, I-Ping Chen, András Váradi, Eszter Kozák, Yasuyuki Fujii, Eliane H Dutra
Publikováno v:
J Bone Miner Res
Craniometaphyseal dysplasia (CMD), a rare genetic bone disorder, is characterized by lifelong progressive thickening of craniofacial bones and metaphyseal flaring of long bones. The autosomal dominant form of CMD is caused by mutations in the progres
Autor:
Boglarka Racz, Srinivasan Jayakumar, Konstantin Petrukhin, Christopher L. Cioffi, Parthasarathy Muthuraman, Arun Raja, Aravindan Jayaraman, András Váradi
Publikováno v:
J Med Chem
Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of proamyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology. ATTR is a progressive disease resulting from the deposition of toxic fibrils in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda8a7259834e8e431ac643fcc5d749f
https://europepmc.org/articles/PMC9578043/
https://europepmc.org/articles/PMC9578043/