Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Andis Klegeris"'
Autor:
Mohammadreza Kosari, Afsaneh Asgari Taei, Andis Klegeris, Sevim Soleimani, Arian Tavasol, Kimia Jazi, Kimia Eyvani, Ashkan Bahrami, Zahra Farrokhi, Farnoosh Vosough, Faraz Rahmani Khajeh, Saleh Behzadi, Zohreh Zamani
Publikováno v:
Caspian Journal of Neurological Sciences, Vol 10, Iss 3, Pp 151-168 (2024)
Background: Parkinson disease (PD) is a prevalent neurodegenerative disorder affecting dopaminergic neurons in the substantia nigra (SN). Neuroinflammation has a vital role in PD pathophysiology. Objectives: This study assesses whether the neuroinfla
Externí odkaz:
https://doaj.org/article/ee898c1994754acd8687184871d600e5
Autor:
Dylan E Da Silva, Christy M Richards, Seamus A McRae, Ishvin Riar, Sijie Shirley Yang, Noah E Zurfluh, Julien Gibon, Andis Klegeris
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0298748 (2024)
Although histone proteins are widely known for their intranuclear functions where they organize DNA, all five histone types can also be released into the extracellular space from damaged cells. Extracellular histones can interact with pattern recogni
Externí odkaz:
https://doaj.org/article/86f6608f38eb4fdabdbc208c7d13b267
Publikováno v:
Brain Sciences, Vol 14, Iss 4, p 328 (2024)
Accumulating evidence indicates that the adverse neuroimmune activation of microglia, brain immunocytes that support neurons, contributes to a range of neuroinflammatory disorders, including Alzheimer’s disease. Correcting the abnormal functions of
Externí odkaz:
https://doaj.org/article/e379c42148af4b7697143fe6c5775660
Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer’s disease
Autor:
Ekta Bajwa, Andis Klegeris
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 11, Pp 2342-2346 (2022)
Alzheimer’s disease, the most common type of dementia among older adults, currently cannot be prevented or effectively treated. Only a very small percentage of Alzheimer’s disease cases have an established genetic cause. The majority of Alzheimer
Externí odkaz:
https://doaj.org/article/9025c40c267b4fafa76cfe53325b5e56
Autor:
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Arian Tavasol, Kimia Jazi, Ashraf Mohamadkhani, Andis Klegeris, Alyssa McElhinney, Zahedeh Mafi, Mohammadreza Hajiesmaeili, Fatemeh Sayehmiri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundMultiple sclerosis (MS) is a debilitating neurodegenerative disorder characterized by axonal damage, demyelination, and perivascular inflammatory lesions in the white matter of the central nervous system (CNS). Kynurenine pathway (KP), whic
Externí odkaz:
https://doaj.org/article/f2e3096d477642b4b11dfecc6a756380
Autor:
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Arian Tavasol, Kimia Jazi, Ramtin Hajibeygi, Sina Shool, Fatemeh Sodeifian, Andis Klegeris, Alyssa McElhinney, Mostafa Rezaei Tavirani, Fatemeh Sayehmiri
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTryptophan (TRP) is an essential amino acid that must be provided in the diet. The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide adenosine dinucleotide (NAD+), and metabolites of this pathway may have protect
Externí odkaz:
https://doaj.org/article/67d33ded9ea741e58109948fdbf0856f
Autor:
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami, Hamed Taheri, Ashraf Mohamadkhani, Ramtin Hajibeygi, Mostafa Rezaei Tavirani, Fatemeh Sayehmiri
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by neuroinflammation, formation of Lewy bodies, and progressive loss of dopaminergic neurons in the substantia nigra of the brain. In this review, we summar
Externí odkaz:
https://doaj.org/article/4d5018910a03444dac5a75ec4e2a4ecd
Autor:
Andis Klegeris
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 3, Pp 423-429 (2021)
Sterile inflammatory processes are essential for the maintenance of central nervous system homeostasis, but they also contribute to various neurological disorders, including neurotrauma, stroke, and demyelinating or neurodegenerative diseases. Immune
Externí odkaz:
https://doaj.org/article/ebc663b929234ffaba1613593de91482
Autor:
Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris
Publikováno v:
Mediators of Inflammation, Vol 2022 (2022)
Alzheimer’s disease (AD) is characterized by chronic neuroinflammation, which is partially mediated by dysregulated functions of glial cells. Cardiolipin (CL) is a phospholipid normally confined to the inner mitochondrial membrane; however, it has
Externí odkaz:
https://doaj.org/article/c72ce61d88be4583ab88add5cde3e38e
Autor:
Jordan A McKenzie, Andis Klegeris
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 7, Pp 1290-1293 (2018)
Neuroinflammation contributes to the neurodegenerative processes in Alzheimer’s disease (AD); therefore, characterization of novel drug candidates aimed at combatting inflammation in the central nervous system is one of the potential avenues for th
Externí odkaz:
https://doaj.org/article/d12215dea6c84bc3a1660800675824fd