Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms

Autor: Andia N. Redpath, Moïra François, Suet-Ping Wong, Dominique Bonnet, Sara M. Rankin

Publikováno v: Blood Advances, Vol 1, Iss 22, Pp 1934-1943 (2017)

Abstract: Pharmacological mobilization of hematopoietic progenitor cells (HPCs) is used clinically to harvest HPCs for bone marrow transplants. It is now widely accepted that the CXCR4:CXCL12 chemokine axis plays a critical role in the retention of H

Externí odkaz: https://doaj.org/article/5e532f57c7814c2c8eeec117d7668c4a

Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of Low Density Lipoprotein Related Protein 1 (LRP1)

Autor: Andia N. Redpath, Nicola Smart, Sonali Munshaw, Benjamin T Pike

ObjectiveAtherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1f803ac3e5a8ef973609f974937fc2
https://doi.org/10.1101/2021.11.30.470548

Maternal iron deficiency impacts the placental arterial network

Autor: Nicola Smart, Dorota Szumska, Jacinta I. Kalisch-Smith, Joaquim M. Vieira, Morris Ec, Andia N. Redpath, J.E. Outhwaite, De Val S, Konstantinos Klaourakis, Paul R. Riley, Strevens Ma, Duncan B. Sparrow

Placental vascular gene networks in mammals have been largely unexplored due to a lack of well validated molecular markers to identify them. This is required to study how they form in development, and how they are impacted by embryonic or maternal de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c02258c8fd11696fc8608cc956df3d
https://doi.org/10.1101/2021.05.06.442902

Thymosin β4 mediates vascular protection via regulation of low density lipoprotein receptor related protein 1 (LRP1)

Autor: Sonali Munshaw, Giles Neal, Karina N. Dubé, Susann Bruche, Jyoti Patel, Nicola Smart, Rachel Davies, Regent Lee, Ashok Handa, Andia N. Redpath, Keith M. Channon

Background and Aims: Thymosin β4 (Tβ4), is a small peptide implicated in mural VSMC differentiation in developing embryo. A proportion of Tβ4KO embryos die with vascular haemorrhage and surviving adults display aortic VSMC and elastin defects. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3696e8f88303fea2ee5e7d65e414c039
https://ora.ox.ac.uk/objects/uuid:e3241180-db55-4a6c-9779-978f44591f92

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery

Autor: Sapan D. Gandhi, Kevin C. Baker, Sara M. Rankin, Moïra François, Daniel Possley, Michael D. Newton, Andia N. Redpath, Paula Urquhart, Adam M. Fahs, Dominique Bonnet, Anna Nicolaou, Tariq G. Fellous, Kate H C Gowers, Suet-Ping Wong, Samantha E. Hartner, Mackenzie M Fleischer

Publikováno v: NPJ Regenerative Medicine
npj Regenerative Medicine
npj Regenerative Medicine, 2020, 5 (1), ⟨10.1038/S41536-020-0088-1⟩
Fellous, T G, Redpath, A N, Fleischer, M M, Gandhi, S, Hartner, S E, Newton, M D, François, M, Wong, S, Gowers, K H C, Fahs, A M, Possley, D R, Bonnet, D, Urquhart, P, Nicolaou, A, Baker, K C & Rankin, S M 2020, ' Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery ', Regenerative Medicine, vol. 5, no. 1 . https://doi.org/10.1038/s41536-020-0088-1
npj Regenerative Medicine, Vol 5, Iss 1, Pp 1-11 (2020)

Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0fb63384f078e79a23facad08cb50f
http://europepmc.org/articles/PMC7035363