Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Andhe V. Narender Reddy"'
1
Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases
Autor: Ronald G. Micetich, Paul Spevak, Oludotun A. Phillips, Herninder Atwal, Samarendra N. Maiti, Eduardo L. Setti, Andhe V. Narender Reddy, Sameeh Salama, David Czajkowski
Publikováno v: Bioorganic & Medicinal Chemistry. 13:2847-2858
The chemical synthesis of a series of new penam sulfone derivatives bearing a 2beta-substituted-oxyimino and -hydrazone substituents, their beta-lactamase inhibitory properties against selected enzymes representing class A and C beta-lactamases are r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963bf608f6170351595fda3d8b5147ac
https://doi.org/10.1016/j.bmc.2005.02.020
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3
Studies on monobactams II. Synthesis and β-lactamase inhibitory activity of 4α-methyl-3-[(thien-2-yl)-methylene]-2-azetidinone-1-sulfonate
Autor: Akio Hyodo, Oludotun A. Phillips, Samarendra N. Maiti, Eduardo L. Setti, Andhe V. Narender Reddy, Ronald G. Micetich, Chieko Kunugita
Publikováno v: Chemistry of Heterocyclic Compounds. 34:1319-1323
Two monobactam derivatives, potassium 4α-methyl-(3E)-[(thien-2-yl)methylene]-2-azetidinone-1-sulfonate and its (3Z)-isomer, were prepared and evaluated for their β-lactamase inhibitory activities. These compounds were devoid of β-lactamase inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42c67d7807fd5c67477b702b7ad04564
https://doi.org/10.1007/bf02256812
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4
7α-methoxy-2-[(substituted)methylene]cephem sulfones as inhibitors of human leukocyte elastase and thrombin
Autor: Andhe V. Narender Reddy, David Czajkowski, Samarendra N. Maiti, Ronald G. Micetich, Charles Fiakpui, Jadwiga Kaleta
Publikováno v: Chemistry of Heterocyclic Compounds. 34:1282-1288
A series of 7α-methoxy-2-[(substituted)methylene]cephem sulfones was synthesized. The compounds with an acetoxy group at the C-3′ position as a leaving group were found to be potent inhibitors of HLE. Selected compounds are also found to be antith
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c621f29cf73b730efd66b989d53642e
https://doi.org/10.1007/bf02256808
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6
Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide
Autor: Eduardo L. Setti, Ronald G. Micetich, Chieko Kunugita, Oludotun A. Phillips, Andhe V. Narender Reddy, David Czajkowski, Samarendra N. Maiti
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:11-14
The synthesis and in vitro synergies of (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide ( 4 ) and 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide ( 15 ) are described. Compound 15 showed good in vitro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::178cf1f433b7d030a7133da06421c87e
https://doi.org/10.1016/s0960-894x(96)00575-6
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7
ChemInform Abstract: 7α-Methoxy-2-[(substituted)methylene]cephem Sulfones as Inhibitors of Human Leukocyte Elastase and Thrombin
Autor: Ronald G. Micetich, David Czajkowski, Samarendra N. Maiti, Charles Fiakpui, Andhe V. Narender Reddy, Jadwiga Kaleta
Publikováno v: ChemInform. 30
A series of 7α-methoxy-2-[(substituted)methylene]cephem sulfones was synthesized. The compounds with an acetoxy group at the C-3′ position as a leaving group were found to be potent inhibitors of HLE. Selected compounds are also found to be antith
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9fb2c4ef07bcb0617c4f2662cc5bccc
https://doi.org/10.1002/chin.199921232
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10
3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors
Autor: Robert Menard, Rajeshwar Singh, Nian E. Zhou, Jadwiga Kaleta, Ronald G. Micetich, Enrico O. Purisima, George Thomas, Deqi Guo, Andhe V. Narender Reddy
Publikováno v: Bioorganicmedicinal chemistry letters. 13(1)
A new class of inhibitors for cysteine proteases cathepsin B, L, K and S is described. These inhibitors are based on the β-lactam ring designed to interact with the nucleophilic thiol of the cysteine in the active site of cysteine proteases. Some 3-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf662c970730d120e0983f782b63970
https://pubmed.ncbi.nlm.nih.gov/12467634
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