Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)

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A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb0795084059f20068b91d6f051cfb
https://pubmed.ncbi.nlm.nih.gov/9135032

New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo.

Autor: Zhang TY; Jilin Medical University, Jilin, 132013, Jilin Province, People's Republic of China., Li CS; The Third People's Hospital of Dalian, Dalian, 116000, People's Republic of China., Cao LT; Jilin Medical University, Jilin, 132013, Jilin Province, People's Republic of China., Bai XQ; Jilin Medical University, Jilin, 132013, Jilin Province, People's Republic of China., Zhao DH; Jilin Medical University, Jilin, 132013, Jilin Province, People's Republic of China. donghaizhao2021@126.com., Sun SM; Zhoushan Hospital, Zhejiang University School of Medicine, Zhoushan, 316021, Zhejiang Province, People's Republic of China. sunsimei1024@163.com.

Publikováno v: Molecular diversity [Mol Divers] 2022 Apr; Vol. 26 (2), pp. 1129-1139. Date of Electronic Publication: 2021 Jun 02.

Neurogonadale Interaktionen bei Frauen mit Epilepsie. (German)

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Publikováno v: Zeitschrift für Epileptologie; Nov2015, Vol. 28 Issue 4, p271-278, 8p

Potential of co-culture of nucleus pulposus mesenchymal stem cells and nucleus pulposus cells in hyperosmotic microenvironment for intervertebral disc regeneration.

Autor: Tao, Yi‐Qing, Liang, Cheng‐Zhen, Li, Hao, Zhang, Yu‐Jie, Li, Fang‐Cai, Chen, Gang, Chen, Qi‐Xin

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Characteristics of myogenic tone in the rat ophthalmic artery.

Autor: Ito, Isamu, Jarajapu, Yagna P. R., Grant, Maria B., Knot, Harm J.

Publikováno v: American Journal of Physiology: Heart & Circulatory Physiology; Jan2007, Vol. 292 Issue 1, pH360-H368, 9p, 6 Graphs