Molecular microarchitecture of macula in health and AMD

Autor: Curcio, CA, Kar, D, Dacey, DM, Anderson, DMG, Kotnala, A, Schey, KL

Publikováno v: 7th International Symposium on AMD: Age-related Macular Degeneration-Understanding Pathogenetic Mechanisms of Disease; 20190920-20190921; Baden-Baden; DOC19amd02 /20200205/

Background: In normal human macula, we investigated with comprehensive molecular and ultrastructural technologies an ecosystem that contributes to drusen lipids (PMID 30357337). Two features of high-risk drusen and their precursors in Bruch’s membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792840a9d9854cc74c0e86e65b6d50cf

Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration.

Autor: Anderson DMG; Department of Biochemistry, Vanderbilt University, Nashville TN., Kotnala A; Department of Biochemistry, Vanderbilt University, Nashville TN.; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham AL., Migas LG; Delft Center for Systems and Control (DCSC), Delft University of Technology, Delft, Netherlands., Patterson NH; Department of Biochemistry, Vanderbilt University, Nashville TN., Tideman L; Delft Center for Systems and Control (DCSC), Delft University of Technology, Delft, Netherlands., Cao D; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham AL., Adhikari B; Vision Science Graduate Program, University of Alabama at Birmingham, Birmingham AL., Messinger JD; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham AL., Ach T; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany., Tortorella S; Molecular Horizon Srl, Via Montelino 30, 06084 Bettona, Perugia, Italy., Van de Plas R; Department of Biochemistry, Vanderbilt University, Nashville TN.; Delft Center for Systems and Control (DCSC), Delft University of Technology, Delft, Netherlands., Curcio CA; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham AL., Schey KL; Department of Biochemistry, Vanderbilt University, Nashville TN.

Publikováno v: Frontiers in ophthalmology [Front Ophthalmol (Lausanne)] 2023; Vol. 3. Date of Electronic Publication: 2023 Nov 24.

High-Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptors Cells and Basal Laminar Deposit of Age-Related Macular Degeneration.

Autor: Anderson DMG; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Kotnala A; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, USA., Messinger JD; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, USA., Patterson NH; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Spraggins JM; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Curcio CA; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, USA., Caprioli RM; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Schey KL; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA. k.schey@vanderbilt.edu.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. k.schey@vanderbilt.edu.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2023; Vol. 1415, pp. 3-7.

Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies.

Autor: Kotnala A; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA., Anderson DMG; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Patterson NH; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Cantrell LS; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Messinger JD; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA., Curcio CA; Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA., Schey KL; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Publikováno v: Journal of mass spectrometry : JMS [J Mass Spectrom] 2021 Dec; Vol. 56 (12), pp. e4798.

Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High-Resolution Imaging Mass Spectrometry.

Autor: Anderson DMG; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States., Messinger JD; Department of Ophthalmology and Visual Science, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Patterson NH; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States., Rivera ES; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States., Kotnala A; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States.; Department of Ophthalmology and Visual Science, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Spraggins JM; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States., Caprioli RM; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States., Curcio CA; Department of Ophthalmology and Visual Science, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Schey KL; Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee 37240, United States.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2020 Dec 02; Vol. 31 (12), pp. 2426-2436. Date of Electronic Publication: 2020 Jul 24.