Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anders Wallenius"'
Autor:
Agata Olszewska-Widdrat, Charilaos Xiros, Anders Wallenius, Roland Schneider, Laís Portugal Rios da Costa Pereira, Joachim Venus
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
The effective and cheap production of platform chemicals is a crucial step towards the transition to a bio-based economy. In this work, biotechnological methods using sustainable, cheap, and readily available raw materials bring bio-economy and indus
Externí odkaz:
https://doaj.org/article/67a79f3e5f304b818fd2af73c454cce8
Publikováno v:
Future Oncology. 10:1853-1861
ABSTRACT: Cancer cells produce high levels of TGFβ, a multipotent cytokine. Binding of TGFβ to its cell surface receptors, the transmembrane serine/threonine kinases TβRII and TβRI, causes phosphorylation and activation of intracellular latent Sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce248b139e1ffcd040d84667e579fbd
https://doi.org/10.2217/fon.14.45
https://doi.org/10.2217/fon.14.45
Autor:
Ida Ericsson, Tara C. Catterall, Antonio Sarno, Torkild Visnes, Henrik Sahlin Pettersen, Arnar Flatberg, Hans E. Krokan, Berit Doseth, Bodil Kavli, Geir Slupphaug, Anders Wallenius
Publikováno v:
Journal of Biological Chemistry. 286:16669-16680
Genomic uracil is a DNA lesion but also an essential key intermediate in adaptive immunity. In B cells, activation-induced cytidine deaminase deaminates cytosine to uracil (U:G mispairs) in Ig genes to initiate antibody maturation. Uracil-DNA glycosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9e7556d22670b00d4b118dd3b172f1
https://doi.org/10.1074/jbc.m111.230052
https://doi.org/10.1074/jbc.m111.230052
Autor:
Thomas Grundström, Bodil Kavli, Antonio Sarno, Hans E. Krokan, Anders Wallenius, Per Arne Aas, Jannek Hauser
Publikováno v:
Molecular immunology. 60(1)
B-lymphocytes can modify their immunoglobulin (Ig) genes to generate specific antibodies with a new isotype and enhanced affinity against an antigen. Activation-induced cytidine deaminase (AID), which is positively regulated by the transcription fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611c9c1b61d80aed66f2e089df023471
https://pubmed.ncbi.nlm.nih.gov/24747958
https://pubmed.ncbi.nlm.nih.gov/24747958
Autor:
Stig O. P. Jacobsson, Anders Wallenius, Sofia B. Gustafsson, Dina Popova, Linus Plym Forshell, Hanna Zackrisson
Compounds acting on the cannabinoid (CB) receptors are involved in the control of cell fate, and there is an emerging consensus that CBs have anticancer effects. However, the CB-mediated effects are contradictory since some studies suggest stimulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d61cc2489db7a64a8cb211e572749b7
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51550
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51550
Publikováno v:
Molecular immunology. 47(5)
To create antibody diversity, B lymphocyte development is characterized by the ordered rearrangement of first immunoglobulin (Ig) heavy chain gene segments and then Ig light-chain gene segments. Early in B-cell development, expression of a pre-B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb368c80db20bf17697c4213d51570f
https://pubmed.ncbi.nlm.nih.gov/20022378
https://pubmed.ncbi.nlm.nih.gov/20022378
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(2)
Differentiation of B lymphocytes into Ab-secreting plasmablasts and plasma cells is Ag driven. The interaction of Ag with the membrane-bound Ab of the BCR is critical in determining which clones enter the plasma cell response. However, not much is kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5138fced370ea04a3cfbbf4265b5b6de
https://pubmed.ncbi.nlm.nih.gov/19553523
https://pubmed.ncbi.nlm.nih.gov/19553523
Autor:
Natalia Sveshnikova, Juha Saarikettu, Jannek Hauser, Sanna Baradaran, Thomas Grundström, Anders Wallenius
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(4)
Upon encountering antigens, B-lymphocytes can adapt to produce a highly specific and potent antibody response. Somatic hypermutation, which introduces point mutations in the variable regions of antibody genes, can increase the affinity for antigen, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb98495799dd4636e3c91821226b07c
https://pubmed.ncbi.nlm.nih.gov/18203819
https://pubmed.ncbi.nlm.nih.gov/18203819