Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Anders Tunek"'
Autor:
Igor L. Shamovsky, Lena Börjesson, Håkan Bladh, Hui Zhang, Eva Lamm Bergström, Anders Tunek, Camilla Johansson, Tomas Drmota, Amir Smailagic, Therese Söderdahl, Annika Åstrand, Anne-Helene Jansson, Cecilia Wingren
Publikováno v:
Pharmacology Research & Perspectives
Although the anti-inflammatory role of the A2a receptor is well established, controversy remains with regard to the therapeutic value for A2a agonists in treatment of inflammatory lung diseases, also as a result of unwanted A2a-mediated cardiovascula
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:591-601
One way to minimise systemic side effects of drugs is to design molecules, soft drugs, in such a way that they are metabolically inactivated rapidly after having acted on their pharmacological target. Hydrolases (esterases, peptidases, lipases, glyco
Autor:
Peter Ballard, Julian Bertschinger-Ehrler, Paul Beswick, Patrick Brassil, Susanne Bredenberg, Khanh H Bui, David Cronk, Hugues Dolgos, Dragan Grabulovski, Philip Grubb, Inger Hägglöf, Raymond G Hill, Åsa Holmgren, Charlotte Keywood, Vincent Lawton, Harry LeVine, Thomas Lundqvist, Paul M Matthews, Alan Naylor, Robert McBurney, Carl Petersson, Humphrey P Rang, Barry Robson, Anders Tunek, Peter J H Webborn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8248fdcc30a5de485270335c74ae9d1
https://doi.org/10.1016/b978-0-7020-4299-7.00028-7
https://doi.org/10.1016/b978-0-7020-4299-7.00028-7
Autor:
Tommy Iliefski, Johan Cassel, Henrik von Wachenfeldt, Tord Inghardt, Anders Tunek, Saswati Ghosal, Sven Nylander, Søren M. Andersen, Andreas Wållberg, Fabrizio Giordanetto, Zhong-Qing Yuan
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p11
Autor:
Peter J. H. Webborn, Anders Tunek, Carl Petersson, Khanh Bui, Hugues Dolgos, Patrick Brassil, Peter Ballard
Publikováno v:
Drug metabolism reviews. 44(3)
The high rate of attrition during drug development and its associated high research and development (R&D) cost have put pressure on pharmaceutical companies to ensure that candidate drugs going to clinical testing have the appropriate quality such th
Publikováno v:
Pharmacology & Toxicology. 69:38-42
1-Methyl-3-phenyl-1,2,3,6-tetrahydropyridine (M-3-PTP) is an analogue to the Parkinson-producing dopaminergic toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). M-3-PTP, and simple analogues thereof, are versatile intermediates in organic syn
Publikováno v:
Biological Mass Spectrometry. 19:218-224
(R,S)-Bambuterol was isolated from plasma and urine by solid-phase extraction and analysed as its trimethylsilyl derivative by gas chromatography/chemical ionization mass spectrometry with ammonia as the reagent gas. Deuterium-labelled bambuterol was
Publikováno v:
Pigment Cell Research. 3:11-15
The effects of N-acetyl-L-cysteine (L-NAC), N,N-diacetyl-L-cystine (oxidized form of L-NAC) and N-acetyl-D-cysteine on the intracellular glutathione (GSH) level and their toxicity were investigated in the human melanoma cell culture IGR1. L-NAC appli
Publikováno v:
Chemico-biological interactions. 94(2)
The effects of the stereoisomers of N-acetylcysteine (L-NAC and D-NAC) on oxygen-induced lung oedema have been studied in rats. The NAC-isomers were given by an osmotic minipump in order to attain continuous administration, either intravenously or in
Publikováno v:
Chemico-biological interactions. 93(2)
The reduction of ferric cytochrome c by various thiols was studied. It was found that L-cysteine, L-cysteine methyl ester and D-penicillamine were very efficient reductants for cytochrome c, whereas N-acetylated amino acids (N-acetyl-L-cysteine and N