Výsledky vyhledávání - "Anders Thorsted"

Akademický článek

Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Autor: Anders Thorsted, Anh Duc Pham, Lena E. Friberg, Elisabet I. Nielsen

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1972-1987 (2023)

Abstract Neutrophil granulocytes are key components of the host response against pathogens, and severe neutropenia, with neutrophil counts below 0.5 × 106 cells/mL, renders patients increasingly vulnerable to infections. Published in vitro (n = 7) a

Externí odkaz: https://doaj.org/article/6e35e4c7af02414faeb6b3437cc32084

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Akademický článek

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Autor: Sabine F. Maarbjerg, Anders Thorsted, Lena E. Friberg, Elisabet I. Nielsen, Mikala Wang, Henrik Schrøder, Birgitte K. Albertsen

Publikováno v: Cancer Reports, Vol 5, Iss 10, Pp n/a-n/a (2022)

Abstract Background Children with febrile neutropenia commonly exhibit alterations of pharmacokinetic (PK) parameters, leading to decreased β‐lactam concentrations. Aims This study evaluated piperacillin PK and probability of target attainment (PT

Externí odkaz: https://doaj.org/article/916249ee1e794aab95228646445fc11e

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Akademický článek

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6.

Autor: Anders Thorsted, Salim Bouchene, Eva Tano, Markus Castegren, Miklós Lipcsey, Jan Sjölin, Mats O Karlsson, Lena E Friberg, Elisabet I Nielsen

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0211981 (2019)

Endotoxin, a component of the outer membrane of Gram-negative bacteria, has been extensively studied as a stimulator of the innate immune response. However, the temporal aspects and exposure-response relationship of endotoxin and resulting cytokine i

Externí odkaz: https://doaj.org/article/5bbba6fc7e5047e68ff171951084ad86

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Continuous infusion of piperacillin-tazobactam significantly improves target attainment in children with cancer and fever

Autor: Birgitte Klug Albertsen, Lena E. Friberg, Henrik Daa Schrøder, Elisabet I. Nielsen, Sabine F. Maarbjerg, Anders Thorsted, Mikala Wang

Publikováno v: Maarbjerg, S F, Thorsted, A, Friberg, L E, Nielsen, E I, Wang, M, Schrøder, H & Albertsen, B K 2022, ' Continuous infusion of piperacillin-tazobactam significantly improves target attainment in children with cancer and fever ', Cancer reports (Hoboken, N.J.), vol. 5, no. 10, e1585 . https://doi.org/10.1002/cnr2.1585

BACKGROUND: Children with febrile neutropenia commonly exhibit alterations of pharmacokinetic (PK) parameters, leading to decreased β-lactam concentrations.AIMS: This study evaluated piperacillin PK and probability of target attainment (PTA) with co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436118aca6e39381fe9ce11bef8eda1a
https://pure.au.dk/portal/da/publications/continuous-infusion-of-piperacillintazobactam-significantly-improves-target-attainment-in-children-with-cancer-and-fever(81d39084-2d4e-4d71-b4c8-55058ae40412).html

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Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue– Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations

Autor: Kristina Öbrink-Hansen, Anh Duc Pham, Mats Bue, Pelle Hanberg, Mathias Bendtsen, Josefine Slater, Lena E. Friberg, Anders Thorsted, Maiken Stilling

Publikováno v: Öbrink-Hansen, K, Pham, A D, Bue, M, Hanberg, P, Bendtsen, M, Slater, J, Friberg, L E, Thorsted, A & Stilling, M 2022, ' Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue– Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations ', Pharmaceutical Research, vol. 39, no. 7, pp. 1633-1643 . https://doi.org/10.1007/s11095-022-03197-y

Purpose: Flucloxacillin is a β-lactam penicillin commonly used in the treatment of bone and soft tissue infections. In a recent porcine study, we found surprisingly low time for which the free concentration was maintained above the minimal inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61369ab45e4e1203f5df58e07a41f48
https://pure.au.dk/portal/da/publications/population-pharmacokinetics-of-flucloxacillin-in-bone-and-soft-tissue-standard-dosing-is-not-sufficient-to-achieve-therapeutic-concentrations(67bd267a-3214-48a6-87e5-66fce99e549f).html

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Population pharmacokinetics of piperacillin following continuous infusion in critically Ill patients and impact of renal function on target attainment

Autor: Merete Storgaard, Vibeke Klastrup, Lena E. Friberg, Kristina Öbrink-Hansen, Steffen Christensen, Anders Thorsted

Publikováno v: Klastrup, V, Thorsted, A, Storgaard, M, Christensen, S, Friberg, L E & Öbrink-Hansen, K 2020, ' Population pharmacokinetics of piperacillin following continuous infusion in critically Ill patients and impact of renal function on target attainment ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 7, e02556-19 . https://doi.org/10.1128/AAC.02556-19
Antimicrob Agents Chemother

Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00e0bf832d26cdb963c2dd8bf704eaf
https://pure.au.dk/portal/da/publications/population-pharmacokinetics-of-piperacillin-following-continuous-infusion-in-critically-ill-patients-and-impact-of-renal-function-on-target-attainment(60fd4ce5-9aa1-4a23-8d4b-c870711fab77).html

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Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy

Autor: Anders Thorsted, Mats Bue, Steffen Christensen, Lena E. Friberg, Tomás Sou, Kristina Öbrink-Hansen, Pelle Hanberg, Anna Sophie L. Okkels, Torben L. Andersson

Publikováno v: Bue, M, Sou, T, Okkels, A S L, Hanberg, P, Thorsted, A, Friberg, L E, Andersson, T L, Öbrink-Hansen, K & Christensen, S 2020, ' Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy ', International Journal of Infectious Diseases, vol. 92, pp. 133-140 . https://doi.org/10.1016/j.ijid.2020.01.010

Objectives: Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with acute kidney injury treated with continuous renal replacement therapy (CRRT). However, data regarding piperacillin tissue concentrations in this pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a54659f153317030b3a515220dbba0
https://pure.au.dk/portal/da/publications/population-pharmacokinetics-of-piperacillin-in-plasma-and-subcutaneous-tissue-in-patients-on-continuous-renal-replacement-therapy(9bd4dee8-0c0b-4627-b11a-99c2ca97ad4e).html

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Pharmacometric Analysis of the Relationship Between Absolute Lymphocyte Count and Expanded Disability Status Scale and Relapse Rate, Efficacy End Points, in Multiple Sclerosis Trials

Autor: Emilie Schindler, Ana M. Novakovic, Anders Thorsted, Mats O. Karlsson, Siv Jönsson, Alain Munafo

Publikováno v: The Journal of Clinical Pharmacology. 58:1284-1294

The aim of this work was to assess the relationship between the absolute lymphocyte count (ALC), and disability (as measured by the Expanded Disability Status Scale [EDSS]) and occurrence of relapses, 2 efficacy endpoints, respectively, in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e955d23ce7d7adf624c57d5eea5368b5
https://doi.org/10.1002/jcph.1136

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Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

Autor: Anders, Thorsted, Eva, Tano, Kia, Kaivonen, Jan, Sjölin, Lena E, Friberg, Elisabet I, Nielsen

Publikováno v: Antimicrobial Agents and Chemotherapy

The release of inflammatory bacterial products, such as lipopolysaccharide (LPS)/endotoxin, may be increased upon the administration of antibiotics. An improved quantitative understanding of endotoxin release and its relation to antibiotic exposure a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c69635dc4c2f7fbc4ae71d8a492c91c1
https://pubmed.ncbi.nlm.nih.gov/31988100

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Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy:the impact of body weight and target on an optimal dosing regimen

Autor: Henrik Daa Schrøder, Elisabet I. Nielsen, Sabine F. Maarbjerg, Mikala Wang, Lena E. Friberg, Anders N. Kristoffersson, Birgitte Brock, Anders Thorsted

Publikováno v: Thorsted, A, Kristoffersson, A N, Maarbjerg, S F, Schrøder, H, Wang, M, Brock, B, Nielsen, E I & Friberg, L E 2019, ' Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy : the impact of body weight and target on an optimal dosing regimen ', Journal of Antimicrobial Chemotherapy, vol. 74, no. 10, pp. 2984-2993 . https://doi.org/10.1093/jac/dkz270
Thorsted, A, Kristoffersson, A N, Maarbjerg, S F, Schrøder, H, Wang, M, Brock, B, Nielsen, E I & Friberg, L E 2019, ' Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy : the impact of body weight and target on an optimal dosing regimen ', The Journal of antimicrobial chemotherapy, vol. 74, no. 10, pp. 2984-2993 . https://doi.org/10.1093/jac/dkz270
J Antimicrob Chemother

Background The β-lactam antibiotic piperacillin (in combination with tazobactam) is commonly chosen for empirical treatment of suspected bacterial infections. However, pharmacokinetic variability among patient populations and across ages leads to un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec63094f3ed42de3da0fd3e68a2d5bc
https://pure.au.dk/ws/files/196903684/dkz270.pdf

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