Impact of dose‐escalation schemes and drug discontinuation on weight loss outcomes with liraglutide 3.0 mg: A model‐based approach

Autor: Theodoros Papathanasiou, Trine Meldgaard Lund, Anders Strathe, Rune Viig Overgaard, Henrik Agersø

Publikováno v: Papathanasiou, T, Strathe, A, Agersø, H, Lund, T M & Overgaard, R V 2020, ' Impact of dose-escalation schemes and drug discontinuation on weight loss outcomes with liraglutide 3.0 mg : A model-based approach ', Diabetes, Obesity and Metabolism, vol. 22, no. 6, pp. 969-977 . https://doi.org/10.1111/dom.13985
Diabetes, Obesity & Metabolism

AIMS: To investigate the impact of treatment changes on weight loss for the glucagon-like peptide-1 analogue, liraglutide, in subjects with overweight or obesity that may be needed in case of gastrointestinal tolerability issues during escalation.MAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633797c326c2ea116b97e8ecfde5052
https://doi.org/10.1111/dom.13985

A bivariate genomic model with additive, dominance and inbreeding depression effects for sire line and three-way crossbred pigs

Autor: Per Madsen, Tage Ostersen, Ingela Velander, Xiang Tao, Guosheng Su, Ole F. Christensen, Bjarne Nielsen, Anders Strathe

Publikováno v: Christensen, O F, Nielsen, B, Su, G, Xiang, T, Madsen, P, Ostersen, T, Velander, I & Strathe, A B 2019, ' A bivariate genomic model with additive, dominance and inbreeding depression effects for sire line and three-way crossbred pigs ', Genetics Selection Evolution, vol. 51, no. 1, 45 . https://doi.org/10.1186/s12711-019-0486-2
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-13 (2019)
Genetics Selection Evolution
Genetics Selection Evolution, BioMed Central, 2019, 51 (1), pp.45. ⟨10.1186/s12711-019-0486-2⟩
Genetics, Selection, Evolution : GSE

Background Crossbreeding is widely used in pig production because of the benefits of heterosis effects and breed complementarity. Commonly, sire lines are bred for traits such as feed efficiency, growth and meat content, whereas maternal lines are al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e9c8ac339ef3af66e26b1e747ede55
https://doi.org/10.1186/s12711-019-0486-2

Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations

Autor: Trine Meldgaard Lund, Andrew C. Hooker, Anders Strathe, Theodoros Papathanasiou, Rune Viig Overgaard

Publikováno v: The AAPS Journal. 20

The exposure-response relationship of combinatory drug effects can be quantitatively described using pharmacodynamic interaction models, which can be used for the selection of optimal dose combinations. The aim of this simulation study was to evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7ea5f295363e26e4b0472a2bd10df5
https://doi.org/10.1208/s12248-018-0226-5