Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Anders R Clausen"'
Autor:
Viktor Posse, Ali Al-Behadili, Jay P Uhler, Anders R Clausen, Aurelio Reyes, Massimo Zeviani, Maria Falkenberg, Claes M Gustafsson
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007781 (2019)
Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP). Here we reconstitute this process in vitro using p
Externí odkaz:
https://doaj.org/article/126e31ef6cce4b9ab4a7126a4f1a5716
Autor:
Kerryn Elliott, Martin Boström, Stefan Filges, Markus Lindberg, Jimmy Van den Eynden, Anders Ståhlberg, Anders R Clausen, Erik Larsson
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007849 (2018)
Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding si
Externí odkaz:
https://doaj.org/article/16b1137887c544f1a82f77607a200878
Autor:
Anna-Karin Berglund, Clara Navarrete, Martin K M Engqvist, Emily Hoberg, Zsolt Szilagyi, Robert W Taylor, Claes M Gustafsson, Maria Falkenberg, Anders R Clausen
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006628 (2017)
Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these. We find that ribonucleotides are distributed evenly betwe
Externí odkaz:
https://doaj.org/article/4a85ef4ec3074dc5bafede1810a9ce1a
Autor:
Krystian Łazowski, Mahmood Faraz, Alexandra Vaisman, Nicholas W Ashton, Piotr Jonczyk, Iwona J Fijalkowska, Anders R Clausen, Roger Woodgate, Karolina Makiela-Dzbenska
Publikováno v:
Nucleic Acids Res
In Escherichia coli, replication of both strands of genomic DNA is carried out by a single replicase—DNA polymerase III holoenzyme (pol III HE). However, in certain genetic backgrounds, the low-fidelity TLS polymerase, DNA polymerase V (pol V) gain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50438fb6e13d0a2cabbaea9559297bd
https://doi.org/10.1093/nar/gkad038
https://doi.org/10.1093/nar/gkad038
Autor:
Jelena Misic, Dusanka Milenkovic, Ali Al-Behadili, Xie Xie, Min Jiang, Shan Jiang, Roberta Filograna, Camilla Koolmeister, Stefan J Siira, Louise Jenninger, Aleksandra Filipovska, Anders R Clausen, Leonardo Caporali, Maria Lucia Valentino, Chiara La Morgia, Valerio Carelli, Thomas J Nicholls, Anna Wredenberg, Maria Falkenberg, Nils-Göran Larsson
Publikováno v:
Nucleic Acids Res
The in vivo role for RNase H1 in mammalian mitochondria has been much debated. Loss of RNase H1 is embryonic lethal and to further study its role in mtDNA expression we characterized a conditional knockout of Rnaseh1 in mouse heart. We report that RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcd16c7d756754674095ebb51a588ff
https://doi.org/10.1093/nar/gkac661
https://doi.org/10.1093/nar/gkac661
Autor:
Andranik Durgaryan, Anders R. Clausen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27deaa2e5967a3f89362cc0697e29928
https://doi.org/10.1007/978-1-0716-2922-2_22
https://doi.org/10.1007/978-1-0716-2922-2_22
Autor:
Danielle L. Watt, Paulina H. Wanrooij, Liam J. Thompson, Katrin Kreisel, Anna-Lena Feldberg, Anna Karin Nilsson, Sushma Sharma, Anders R. Clausen, Clara Navarrete, Gustavo Carvalho, Andrei Chabes, Martin K. M. Engqvist, Phong Tran
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mammalian mitochondria contain their own genome (mtDNA) that encodes key subunits of the machinery that produces the majority of the cell’s energy. mtDNA integrity is crucial for normal energy production, and its loss due to deletions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3535937b2dba6b4540da63128926842
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171765
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171765
Autor:
Louise Slot Christiansen, Anders R. Clausen, Zeeshan Mutahir, Jure Piškur, Zoran Gojkovic, Martin W. Berchtold, Birgitte Munch-Petersen, Wolfgang Knecht
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 35:677-690
Deoxyribonucleoside kinases (dNKs) salvage deoxyribonucleosides (dNs) and catalyze the rate limiting step of this salvage pathway by converting dNs into corresponding monophosphate forms. These enzymes serve as an excellent model to study duplicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c09b6c8e9ad928622a8f5a431f90fa
https://doi.org/10.1080/15257770.2016.1143557
https://doi.org/10.1080/15257770.2016.1143557
Autor:
Engqvist Mkm, Katrin Kreisel, Anna Karin Nilsson, Liam J. Thompson, Sushma Sharma, Anders R. Clausen, Paulina H. Wanrooij, Anna-Lena Feldberg, Phong Tran, Andrei Chabes, Clara Navarrete, Danielle L. Watt
Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not removed in a timely manner. However, the presence of a certain level of rNMPs is tolerated in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf0104e5fea3d3cda6f1f3f229f5497
https://doi.org/10.1101/746719
https://doi.org/10.1101/746719
Autor:
Stefan Filges, Anders R. Clausen, Jimmy Van den Eynden, Martin Boström, Erik Larsson, Anders Ståhlberg, Kerryn Elliott, Markus Lindberg
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007849 (2018)
PLoS Genetics
PLoS Genetics
Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517083370a68e3a7257531ec31e0e6c9
https://doaj.org/article/16b1137887c544f1a82f77607a200878
https://doaj.org/article/16b1137887c544f1a82f77607a200878