Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Anders Peter Larsen"'
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9021 (2010)
BACKGROUND: The repolarizing cardiac rapid delayed rectifier current, I(Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I(Kr). Marked heterogeneity in the kinetic pro
Externí odkaz:
https://doaj.org/article/0a5f120e63294fddbb0f9ae257403bf5
Publikováno v:
Sundbøll, J, Larsen, A P, Veres, K, Adelborg, K & Sørensen, H T 2019, ' Cardiovascular event rates and trajectories of LDL-cholesterol levels and lipid-lowering therapy in patients with atherosclerotic cardiovascular disease : A population-based cohort study ', Thrombosis Research, vol. 183, pp. 124-130 . https://doi.org/10.1016/j.thromres.2019.09.034
Background An understanding of cardiovascular event rates and low-density lipoprotein cholesterol (LDL-C) levels and trajectories in patients with atherosclerotic cardiovascular disease is needed to evaluate treatment goals and adherence to guideline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33b312307e3242396ade6824f3fc376
https://pubmed.ncbi.nlm.nih.gov/31677592
https://pubmed.ncbi.nlm.nih.gov/31677592
Autor:
Nicole Schmitt, Anders Peter Larsen, Søren Grubb, Anders G. Holst, Søren-Peter Olesen, Morten S. Olesen, Jesper Hastrup Svendsen, Kirstine Calloe, Lena Refsgaard, Stig Haunsø
Publikováno v:
Cardiovascular Research. 98:488-495
Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward pota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d0bc8f54607e70cba60127aac6452
https://doi.org/10.1093/cvr/cvt028
https://doi.org/10.1093/cvr/cvt028
Publikováno v:
Chronobiology international. 34(1)
Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and sudden cardiac death. We investigated the hypothesis that there is no circadian rhythm i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c71bfdc4aea8b0aef92cf92c007bded
https://pubmed.ncbi.nlm.nih.gov/27736193
https://pubmed.ncbi.nlm.nih.gov/27736193
Autor:
Rengasayee Veeraraghavan, Steven Poelzing, Anders Peter Larsen, Morten Grunnet, Natalia S. Torres
Publikováno v:
Acta Physiologica. 207:280-289
Aims: Diminished repolarization reserve contributes to the arrhythmogenic substrate in many disease states. Pharmacological activation of K + channels has been suggested as a potential antiarrhythmic therapy in such conditions. Having previously demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6964cf067dac2c7b8adeb4c0ff583e56
https://doi.org/10.1111/j.1748-1716.2012.02481.x
https://doi.org/10.1111/j.1748-1716.2012.02481.x
Publikováno v:
Biophysical Journal. 101(4):818-827
Kv7.1 (KCNQ1) channels are regulators of several physiological processes including vasodilatation, repolarization of cardiomyocytes, and control of secretory processes. A number of Kv7.1 pore mutants are sensitive to extracellular potassium. We hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a588d7b3a7cec257d894bae0b8b018e5
Autor:
Morten Grunnet, Kezhong Wu, Karin Storm van´s Gravesande, Katja E. Odening, Xuwen Peng, Jürgen Biermann, Christoph Bode, Anders Peter Larsen, Gideon Koren, Gerlind Franke, Manfred Zehender, Bo Hjorth Bentzen, Sophia Bahrke, Michael Brunner
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:223-230
Transgenic rabbits expressing pore mutants of K(V)7.1 display a long QT syndrome 1 (LQT1) phenotype. Recently, NS1643 has been described to increase I(Kr).We hypothesized that NS1643 would shorten the action potential duration (APD(90)) in LQT1 rabbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8196d9ee0ab37070b0624fa328a09bc
https://doi.org/10.1097/fjc.0b013e318203a44d
https://doi.org/10.1097/fjc.0b013e318203a44d
Publikováno v:
British Journal of Pharmacology. 161:614-628
BACKGROUND AND PURPOSE K v 11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K v 11.1a and K v 11.1b, with different kinetics, are expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d6dd531cb4f5a280c8163bc737f2129
https://doi.org/10.1111/j.1476-5381.2010.00897.x
https://doi.org/10.1111/j.1476-5381.2010.00897.x
Autor:
Anders Peter Larsen
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 460:803-812
The 'ether-a-go-go-related' gene type 1 (ERG1 or Kv11.1) protein is the product of the KCNH2 gene. Currents generated by ERG1 channels are important in a range of tissues including neuronal, smooth muscle, and cardiac tissues, as well as in cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c623497321a777f6dcb223d174032fc
https://doi.org/10.1007/s00424-010-0855-8
https://doi.org/10.1007/s00424-010-0855-8
Autor:
Pia R. Lundegaard, Anders Peter Larsen, David J. Porteous, Rowland R. Sillito, Nicola J. Grant, J. Douglas Armstrong, Karthika Paranthaman, E. Elizabeth Patton, Zhiqiang Zeng, Corina Anastasaki, Judith Zich
Publikováno v:
Chemistry & Biology
Lundegaard, P R, Anastasaki, C, Grant, N J, Sillito, R R, Zich, J, Zeng, Z, Paranthaman, K, Larsen, A P, Armstrong, J D, Porteous, D J & Patton, E E 2015, ' MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish ', Chemistry and Biology . https://doi.org/10.1016/j.chembiol.2015.08.010
Lundegaard, P R, Anastasaki, C, Grant, N J, Sillito, R R, Zich, J, Zeng, Z, Paranthaman, K, Larsen, A P, Armstrong, J D, Porteous, D J & Patton, E E 2015, ' MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish ', Chemistry and Biology . https://doi.org/10.1016/j.chembiol.2015.08.010
Summary Altered phosphodiesterase (PDE)-cyclic AMP (cAMP) activity is frequently associated with anxiety disorders, but current therapies act by reducing neuronal excitability rather than targeting PDE-cAMP-mediated signaling pathways. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3a6b98c00700306ac5314651beedef
https://pubmed.ncbi.nlm.nih.gov/26388333
https://pubmed.ncbi.nlm.nih.gov/26388333