Recognition of guanosine by dissimilar tRNA methyltransferases

Autor: Saulius Klimašauskas, Anders M.B. Giessing, Joseph A. Piccirilli, Ya-Ming Hou, Qing Dai, Georges Lahoud, Zita Liutkeviciute, Finn Kirpekar, Reiko Sakaguchi

Publikováno v: RNA. 18:1687-1701

Guanosines are important for biological activities through their specific functional groups that are recognized for RNA or protein interactions. One example is recognition of N1 of G37 in tRNA by S-adenosyl-methionine (AdoMet)–dependent tRNA methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a080ad7b900afa63816fb81f45d77bb
https://doi.org/10.1261/rna.032029.111

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

Autor: Søren Skov Jensen, Birte Vester, Andrzej Gondela, Anders M.B. Giessing, Anette Rasmussen, Finn Kirpekar, Katherine S. Long, Lykke Haastrup Hansen

Publikováno v: Giessing, A, Jensen, S S, Rasmussen, A, Hansen, L H, Gondela, A, Long, K, Vester, B & Kirpekar, F 2009, ' Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria ', RNA: A publication of the RNA Society, vol. 15, no. 2, pp. 327-336 . https://doi.org/10.1261/rna.1371409

The Cfr methyltransferase confers combined resistance to five different classes of antibiotics that bind to the peptidyl transferase center of bacterial ribosomes. The Cfr-mediated modification has previously been shown to occur on nucleotide A2503 o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b0bb1715e003574d5e095ce2a45d18
https://doi.org/10.1261/rna.1371409

Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA

Autor: Trine Møller Hansen, Lincoln G. Scott, Anette Rasmussen, Finn Kirpekar, Jesper F. Havelund, Anders M.B. Giessing

Publikováno v: Havelund, J F, Giessing, A M B, Hansen, T M, Rasmussen, A, Scott, L G & Kirpekar, F 2011, ' Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA ', Journal of Molecular Biology, vol. 411, no. 3, pp. 529-536 . https://doi.org/10.1016/j.jmb.2011.06.036

Complete characterization of a biomolecule's chemical structure is crucial in the full understanding of the relations between their structure and function. The dominating components in ribosomes are ribosomal RNAs (rRNAs), and the entire rRNA—but a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf75895377fc6069e592ea16fa4de4fc
https://portal.findresearcher.sdu.dk/da/publications/6d8260ad-a616-4d2a-afdb-862b7bb285f6

Towards liquid chromatography time-scale peptide sequencing and characterization of post-translational modifications in the negative-ion mode using electron detachment dissociation tandem mass spectrometry

Autor: Frank Kjeldsen, Ole N. Jensen, Anders M.B. Giessing, Ole Hørning, Søren Sindberg Jensen

Publikováno v: Kjeldsen, F, Hørning, O B, Jensen, S S, Giessing, A & Jensen, O N 2008, ' Towards Liquid Chromatography Time-Scale Peptide Sequencing and Characterization of Post-Translational Modifications in the Negative-Ion Mode Using Electron Detachment Dissociation Tandem Mass Spectrometry ', Journal of the American Society for Mass Spectrometry, vol. 19, no. 8, pp. 1156-1162 . https://doi.org/10.1016/j.jasms.2008.04.031

Electron detachment dissociation (EDD) of peptide poly-anions is gentle towards post-translational modifications (PTMs) and produces predictable and interpretable fragment ion types (a·, x ions). However, EDD is considered an inefficient fragmentati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ec8c4c40e4e3e68ffd66f1251ddd5d
https://pubmed.ncbi.nlm.nih.gov/18555696

Investigating the biomarker potential of glycoproteins using comparative glycoprofiling - application to tissue inhibitor of metalloproteinases-1

Autor: Nils Brünner, Ida B. Thøgersen, Peter Højrup, Jan J. Enghild, Ulrik Lademann, Hanne Offenberg, Morten Thaysen-Andersen, Anders M.B. Giessing, Hans Jørgen Nielsen

Publikováno v: Thaysen-Andersen, M, Thøgersen, I B, Lademann, U, Offenberg, H, Giessing, A, Enghild, J J, Nielsen, H J, Brünner, N & Højrup, P 2008, ' Investigating the biomarker potential of glycoproteins using comparative glycoprofiling-application to tissue inhibitor of metalloproteinases-1 ', BBA General Subjects, vol. 1784, no. 3, pp. 455-463 . https://doi.org/10.1016/j.bbapap.2007.12.007
Thaysen-Andersen M, M, Thøgersen, I, Lademann, U, Offenberg, H, Giessing, AM, Enghild, J J, Nielsen, HJ, Brünner, N & Højrup P., P 2007, ' Investigating the biomarker potential of glycoproteins using comparative glycoprofiling-application to tissue inhibitor of metalloproteinases-1. ', Biochim. Biophys. Acta. .
Thaysen-Andersen, M, Thøgersen, I, Lademann, U, Offenberg, H, Enghild, J J, Nielsen, HJ, Giessing, AM, Brünner, N & Højrup, P 2008, ' Investigating the biomarker potential of glycoproteins using comparative glycoprofiling-application to tissue inhibitor of metalloproteinases-1 ', BBA General Subjects, vol. 3, no. 1784 .

Udgivelsesdato: Mar Cancer-induced alterations of protein glycosylations are well-known phenomena. Hence, the glycoprofile of certain glycoproteins can potentially be used as biomarkers for early diagnosis. However, there are a substantial number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a3396f7de6b6e6c3427dcde2bb8af1
https://portal.findresearcher.sdu.dk/da/publications/b196ee00-d94d-11dc-860c-000ea68e967b