Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Anders M. Knight"'
Autor:
John A. McIntosh, Tamas Benkovics, Steven M. Silverman, Mark A. Huffman, Jongrock Kong, Peter E. Maligres, Tetsuji Itoh, Hao Yang, Deeptak Verma, Weilan Pan, Hsing-I Ho, Jonathan Vroom, Anders M. Knight, Jessica A. Hurtak, Artis Klapars, Anna Fryszkowska, William J. Morris, Neil A. Strotman, Grant S. Murphy, Kevin M. Maloney, Patrick S. Fier
Publikováno v:
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Externí odkaz:
https://doaj.org/article/0dca7a33b3304dad9cbbea813d344184
Autor:
Anders M. Knight, S. B. Jennifer Kan, Russell D. Lewis, Oliver F. Brandenberg, Kai Chen, Frances H. Arnold
Publikováno v:
ACS Central Science, Vol 4, Iss 3, Pp 372-377 (2018)
Externí odkaz:
https://doaj.org/article/57854300ada54c8faf11446f3e61e4a8
Autor:
Jessica A. Hurtak, Steven M. Silverman, Kevin M. Maloney, Patrick S. Fier, Jonathan Vroom, Neil A. Strotman, Mark A. Huffman, Hao Yang, Peter E. Maligres, Tamas Benkovics, Anders M. Knight, Grant S. Murphy, Weilan Pan, Artis Klapars, Jongrock Kong, William J. Morris, John A. McIntosh, Tetsuji Itoh, Hsing-I Ho, Anna Fryszkowska, Deeptak Verma
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to develop a short and sustainable synthesis from sim
Autor:
Frances H. Arnold, Bruce J. Wittmann, Julie L. Hofstra, Anders M. Knight, S. B. Jennifer Kan, Sarah E. Reisman
Publikováno v:
ACS Catal
While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d341980e44cfb5658215331dc69448c
https://resolver.caltech.edu/CaltechAUTHORS:20200608-115355402
https://resolver.caltech.edu/CaltechAUTHORS:20200608-115355402
Publikováno v:
J Am Chem Soc
Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that Pseudomonas savastanoi ethylene-forming enzyme (PsEFE), a non-heme iron enzyme, can catalyze olefin aziridination and nitrene C–H insertion, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb1aba006212962763f16a8834ee47f
https://resolver.caltech.edu/CaltechAUTHORS:20191125-092520827
https://resolver.caltech.edu/CaltechAUTHORS:20191125-092520827
Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that a non-heme iron enzyme can catalyze olefin aziridination and nitrene C–H insertion, and that these activities can be improved by directed evolut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5d4a7ae2338b88b76a938a5376abd6a
https://doi.org/10.26434/chemrxiv.10062044
https://doi.org/10.26434/chemrxiv.10062044
Autor:
Oliver F. Brandenberg, Anders M. Knight, Kai Chen, Frances H. Arnold, Russell D. Lewis, S. B. Jennifer Kan
Publikováno v:
ACS Central Science
ACS Central Science, Vol 4, Iss 3, Pp 372-377 (2018)
ACS Central Science, Vol 4, Iss 3, Pp 372-377 (2018)
Developing catalysts that produce each stereoisomer of a desired product selectively is a longstanding synthetic challenge. Biochemists have addressed this challenge by screening nature’s diversity to discover enzymes that catalyze the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f0666dd4105b49fc59bdad107817ab
https://doi.org/10.26434/chemrxiv.5718076
https://doi.org/10.26434/chemrxiv.5718076
Autor:
Dirk Albrecht, Uwe T. Bornscheuer, Maika Genz, Katharina Riedel, Tom van den Bergh, Henk-Jan Joosten, Alberto Nobili, Anders M. Knight, Ioannis V. Pavlidis
Pyridoxal-5′-phosphate (PLP)-dependent enzymes are ubiquitous in nature and catalyze a variety of important metabolic reactions. The fold-type III PLP-dependent enzyme family is primarily comprised of decarboxylases and alanine racemases. In the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdff11b1298edd95fc69b90a41712412
https://resolver.caltech.edu/CaltechAUTHORS:20161107-083446944
https://resolver.caltech.edu/CaltechAUTHORS:20161107-083446944
Autor:
Taisong Zou, Silvia Cavagnero, S. Banu Ozkan, Neşe Kurt-Yilmaz, Anders M. Knight, Peter H. Culviner
Publikováno v:
ACS chemical biology. 8(6)
The crucial molecular events accompanying protein folding in the cell are still largely unexplored. As nascent polypeptides emerge from the ribosomal exit tunnel, they come in close proximity with the highly negatively charged ribosomal surface. How