Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Anders Lundin"'
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Mohammad Bohlooly-Y, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine B. Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended muta
Externí odkaz:
https://doaj.org/article/4bb0c69502654c769c92ef8642d93a46
Autor:
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J. Porritt, Sandra Wimberger, Anders Lundin, Carl Möller, Mike Firth, Euan Gordon, Bojana Lazovic, Aleksandra Sieńska, Luna Simona Pane, Matthew A. Coelho, Giovanni Ciotta, Giovanni Pellegrini, Marcella Sini, Xiufeng Xu, Suman Mitra, Mohammad Bohlooly-Y, Benjamin J. M. Taylor, Grzegorz Sienski, Marcello Maresca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in
Externí odkaz:
https://doaj.org/article/5902061ff2c8407598c33e5d4d157a46
Autor:
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be
Externí odkaz:
https://doaj.org/article/8d05a4aa843b419591409ca746b331db
Autor:
Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, Anna Falk
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1030-1045 (2018)
Summary: In vivo studies of human brain cellular function face challenging ethical and practical difficulties. Animal models are typically used but display distinct cellular differences. One specific example is astrocytes, recently recognized for con
Externí odkaz:
https://doaj.org/article/744833d558064ed48a43910333ebf5f2
Autor:
Anders Lundin, Anna Falk
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 847-849 (2018)
Astrocytes have important functions in the brain and their deregulation may cause disease. Current ways to derive astrocytes from pluripotent stem cells are labor, time, and resource intensive, but in this issue of Stem Cell Reports, Li et al. presen
Externí odkaz:
https://doaj.org/article/f88369f93bd54d10a4a8e64508166a8c
Autor:
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J. Porritt, Sandra Wimberger, Anders Lundin, Carl Möller, Mike Firth, Euan Gordon, Bojana Lazovic, Aleksandra Sieńska, Luna Simona Pane, Matthew A. Coelho, Giovanni Ciotta, Giovanni Pellegrini, Marcella Sini, Xiufeng Xu, Suman Mitra, Mohammad Bohlooly-Y, Benjamin J. M. Taylor, Grzegorz Sienski, Marcello Maresca
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/751b936669984511ba04755a2e74efd0
Autor:
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Bohlooly-Y Mohammad, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca
Genome editing tools, especially CRISPR/Cas9-based strategies, have transformed biomedical research and opened opportunities for developing curative treatments for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08601f80723c09f5557274e0ab558c2
https://doi.org/10.1101/2022.12.15.520396
https://doi.org/10.1101/2022.12.15.520396
Autor:
Frank Seeliger, Carla P. Martins, Emily James, Sandra Wimberger, Camilla Johansson, Mohammad Bohlooly-Y, Emma J. Davies, Maryam Clausen, Lukas Badertscher, Michelle J. Porritt, Simon T. Barry, Xiufeng Xu, Anna Schantz, Roberto Nitsch, Amir Taheri-Ghahfarokhi, Marcello Maresca, Himjyot Jaiswal, Elizabeth Hardaker, Jenna Bradley, Babak Alaeimahabadi, Lorenz M. Mayr, Abdel Wahad Bidar, Therese Admyre, Anders Lundin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still expensive and time-consuming, demanding more target flexibility and faster turnaround times
Autor:
Mohammad Bohlooly-Y, Nina Akrap, Benjamin J. M. Taylor, Euan Gordon, Grzegorz Sienski, Mike Firth, Giovanni Ciotta, Anders Lundin, Matthew A. Coelho, Silvia Cerboni, Aleksandra Sieńska, Marcella Sini, Marcello Maresca, Luna Simona Pane, Giovanni Pellegrini, Xiufeng Xu, Songyuan Li, Suman Mitra, Bojana Lazovic, Sandra Wimberger, Carl Möller, Michelle J. Porritt
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the efficiency of genome editing remains low, impeding the development of gene- and cell-based
Autor:
Amir Taheri-Ghahfarokhi, Alaeimahabadi B, Anders Lundin, Frank Seeliger, Lukas Badertscher, Lorenz M. Mayr, Carla P. Martins, Xiufeng Xu, Camilla Johansson, Therese Admyre, Mohammad Bohlooly-Y, Emma J. Davies, Simon T. Barry, Abdel Wahad Bidar, Marcello Maresca, Anna Schantz, Maryam Clausen, Michelle J. Porritt, Elizabeth Hardaker, Jenna Bradley, Roberto Nitsch, Himjyot Jaiswal
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still expensive and time-consuming, demanding more target flexibility and faster turnaround times
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87692a8b8c939432739b4366cbb0f0a7
https://doi.org/10.1101/2020.04.06.028803
https://doi.org/10.1101/2020.04.06.028803