Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anders Laustsen"'
Autor:
Ditte Jaehger, Iulia Diaconu, Anders Laustsen, Tobias W Bjerg, Aida S Hansen, Trine I Jensen, Mette-Louise Trempenau, Kasper M Jensen, Nicolai O Haahr, Marcus N Rosendal, Jonas B Vejlebo, Rasmus O Bak, Martin R Jakobsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/be21790330ad40b3a927b263360bf8a2
Autor:
Anders Laustsen, Renée M van der Sluis, Albert Gris-Oliver, Sabina Sánchez Hernández, Ena Cemalovic, Hai Q Tang, Lars Henning Pedersen, Niels Uldbjerg, Martin R Jakobsen, Rasmus O Bak
Publikováno v:
eLife, Vol 10 (2021)
Plasmacytoid dendritic cells (pDCs) constitute a rare type of immune cell with multifaceted functions, but their potential use as a cell-based immunotherapy is challenged by the scarce cell numbers that can be extracted from blood. Here, we systemati
Externí odkaz:
https://doaj.org/article/6f3798286f634c3eb305fef770b61810
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus
Externí odkaz:
https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087
Autor:
Jason A Neidleman, Joseph C Chen, Nargis Kohgadai, Janis A Müller, Anders Laustsen, Karthiga Thavachelvam, Karen S Jang, Christina M Stürzel, Jennifer J Jones, Christina Ochsenbauer, Avantika Chitre, Ma Somsouk, Maurice M Garcia, James F Smith, Ruth M Greenblatt, Jan Münch, Martin R Jakobsen, Linda C Giudice, Warner C Greene, Nadia R Roan
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006163 (2017)
Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines
Externí odkaz:
https://doaj.org/article/215523000fcd44e1b62ce98ad7785188
Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors
Autor:
Yujia Cai, Anders Laustsen, Yan Zhou, Chenglong Sun, Mads Valdemar Anderson, Shengting Li, Niels Uldbjerg, Yonglun Luo, Martin R Jakobsen, Jacob Giehm Mikkelsen
Publikováno v:
eLife, Vol 5 (2016)
Biased integration remains a key challenge for gene therapy based on lentiviral vector technologies. Engineering of next-generation lentiviral vectors targeting safe genomic harbors for insertion is therefore of high relevance. In a previous paper (C
Externí odkaz:
https://doaj.org/article/d676c9c047f64c25b880607d88df8367
Autor:
Renée M van der Sluis, Lamin B Cham, Albert Gris‐Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cémalovic, Stine H Godsk, Jacob Thyrsted, Jesper D Gunst, Silke D Nielsen, Janni J Jørgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian K Holm, Martin Tolstrup, Søren R Paludan, Lasse S Kristensen, Ole S Søgaard, Martin R Jakobsen
Publikováno v:
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Sanches Hernandez, S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Wang Bjerg, T, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', The EMBO Journal, pp. e109622 . https://doi.org/10.15252/embj.2021109622
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Hernandez, S S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Bjerg, T W, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', EMBO Journal, vol. 41, no. 10, e109622 . https://doi.org/10.15252/embj.2021109622
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Hernandez, S S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Bjerg, T W, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', EMBO Journal, vol. 41, no. 10, e109622 . https://doi.org/10.15252/embj.2021109622
Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here, we find decreasing number of circulating plasmacytoid dendritic cells
Autor:
Chiranjeevi Bodda, Søren B. Jensen, Carsten Scavenius, Anne Troldborg, Christine Doucet, Cheng long Sun, Ramya Nandakumar, Anders Laustsen, Thaneas Prabakaran, Zong liang Gao, Samuel J. Windross, Harald Stenmark, Zheng Guo, Line S. Reinert, Sonia Assil, Rune Hartmann, Søren R. Paludan, Jinrong Huang, Martin K. Thomsen, Yan Zhang, Ryo Narita, Jan J. Enghild, Bao cun Zhang, Zhijian J. Chen, Raphaela Goldbach-Mansky, Takeshi Noda, David Olagnier, Rasmus O. Bak, Cong gang Zhang, Martin F. Berthelsen, Yujia Cai
Publikováno v:
Nature immunology
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occ
Publikováno v:
Beck, K M, L. Pham, R, A. Nanim, R, Laustsen, A & Nielsen, P 2021, ' Double-Headed Nucleotides with Increased Base-Pairing Affinity and Specificity ', European Journal of Organic Chemistry, vol. 2021, no. 48, pp. 6717-6724 . https://doi.org/10.1002/ejoc.202101209
Double-headed nucleotides, i. e., nucleotides that hold two nucleobases each, have been shown to be double-functional in DNA duplexes by forming two sets of Watson−Crick base pairs, and thus mimicking dinucleotides. Herein, we present three new dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d107f4fe7bcd69fcef90173da69611
https://portal.findresearcher.sdu.dk/da/publications/0d824ac6-eb7e-40e9-b922-242af6282025
https://portal.findresearcher.sdu.dk/da/publications/0d824ac6-eb7e-40e9-b922-242af6282025
Autor:
Jesper Geert Pedersen, Kristine Raaby Gammelgaard, Jakob Thyrsted, Martin Tolstrup, Lamin B Cham, Ole S. Søgaard, Lasse Sommer Kristensen, Tobias W Bjerg, Stine Høvring Godsk, Anders Laustsen, Line S. Reinert, David Olagnier, Søren R. Paludan, Renée M. van der Sluis, Manja Idorn, Janni j Jorgensen, Alberg Gris Oliver, Mads Kjolby, Silke D Nielsen, Sabina Sánchez Hernández, Rasmus O. Bak, Ulvi Ahmodov, Christian K. Holm, Ena Cemalovic, Jesper Damsgaard Gunst, Martin R. Jakobsen
Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here we show that in COVID-19 patients, circulating plasmacytoid dendritic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f776416cf8fa82da3a7207b9af1466a4
https://doi.org/10.1101/2021.11.23.469755
https://doi.org/10.1101/2021.11.23.469755