Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Anders Lade Nielsen"'
Autor:
Christoffer Trier Maansson, Peter Meldgaard, Magnus Stougaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 722-736 (2023)
Cell‐free DNA (cfDNA) in blood plasma can be bound to nucleosomes that contain post‐translational modifications representing the epigenetic profile of the cell of origin. This includes histone H3 lysine 36 trimethylation (H3K36me3), a marker of a
Externí odkaz:
https://doaj.org/article/d4898b4fdb484ec09ae806f348de054c
Autor:
Christoffer Trier Månsson, Johan Vad‐Nielsen, Peter Meldgaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 2868-2876 (2021)
Determination of tumour‐specific transcription based on liquid biopsies possesses a large diagnostic and prognostic potential in non‐small cell lung cancer (NSCLC). Cell‐free DNA (cfDNA) packed in nucleosomes mirrors the histone modification pr
Externí odkaz:
https://doaj.org/article/215d9d2d9c6e4358ba4b2f9354903872
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-14 (2019)
Abstract Background Programmed cell death ligand-1 (PD-L1) and ligand-2 (PD-L2) interaction with programmed cell death protein-1 (PD-1) represent an immune-inhibiting checkpoint mediating immune evasion and is, accordingly, an important target for bl
Externí odkaz:
https://doaj.org/article/a90dd24ce10c4b48a6c7a4861ea35a2a
Autor:
Kristine Raaby Gammelgaard, Johan Vad-Nielsen, Michelle Simone Clement, Simone Weiss, Tina Fuglsang Daugaard, Frederik Dagnæs-Hansen, Peter Meldgaard, Boe Sandahl Sorensen, Anders Lade Nielsen
Publikováno v:
Translational Oncology, Vol 12, Iss 3, Pp 432-440 (2019)
Non-small cell lung carcinoma patients with epidermal growth factor receptor (EGFR) mutations are offered EGFR tyrosine kinase inhibitors (TKI) as first line treatment, but 20–40% of these patients do not respond. High expression of alternative rec
Externí odkaz:
https://doaj.org/article/95de9a5034e840a880f923bc69715d00
Autor:
Nicklas Heine Staunstrup, Anna Starnawska, Mette Nyegaard, Anders Lade Nielsen, Anders Dupont Børglum, Ole Mors
Publikováno v:
Epigenomes, Vol 1, Iss 3, p 23 (2017)
Background: Epigenetic epidemiology has proven an important research discipline in the delineation of diseases of complex etiology. The approach, in such studies, is often to use bio-banked clinical material, however, many such samples were collected
Externí odkaz:
https://doaj.org/article/010d1385b5b648c1a6baacf1171be0d5
Autor:
Nicklas Heine Staunstrup, Anna Starnawska, Mette Nyegaard, Anders Lade Nielsen, Anders Børglum, Ole Mors
Publikováno v:
Epigenomes, Vol 1, Iss 3, p 14 (2017)
Abstract: Background: Interrogation of DNA methylation profiles hold promise for improved diagnostics, as well as the delineation of the aetiology for common human diseases. However, as the primary tissue of the disease is often inaccessible without
Externí odkaz:
https://doaj.org/article/af371f70d8b743359e3aad263a03e1e1
Publikováno v:
PLoS ONE, Vol 8, Iss 11 (2013)
Externí odkaz:
https://doaj.org/article/45b0310a377e42c4b4c555bfd8ea475d
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72110 (2013)
The intermediate filament network of astrocytes includes Glial fibrillary acidic protein (Gfap) as a major component. Gfap mRNA is alternatively spliced resulting in generation of different protein isoforms where Gfapα is the most predominant isofor
Externí odkaz:
https://doaj.org/article/a1b0a68687db4837a9c193e757c55e2f
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46251 (2012)
The FET family of proteins is composed of FUS/TLS, EWS/EWSR1, and TAF15 and possesses RNA- and DNA-binding capacities. The FET-proteins are involved in transcriptional regulation and RNA processing, and FET-gene deregulation is associated with develo
Externí odkaz:
https://doaj.org/article/72584728e6e54bc39eec42b188f4cdb6
Autor:
Fei Gao, Yonglun Luo, Shengting Li, Jian Li, Lin Lin, Anders Lade Nielsen, Charlotte Brandt Sørensen, Gábor Vajta, Jun Wang, Xiuqing Zhang, Yutao Du, Huanming Yang, Lars Bolund
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25901 (2011)
Animal breeding via Somatic Cell Nuclear Transfer (SCNT) has enormous potential in agriculture and biomedicine. However, concerns about whether SCNT animals are as healthy or epigenetically normal as conventionally bred ones are raised as the efficie
Externí odkaz:
https://doaj.org/article/c43469de05344253922a6bd6cec8ae99