Výsledky vyhledávání - "Anders Kallin"

Akademický článek

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55γ

Autor: Anders Kallin, Lene E. Johannessen, Patrice D. Cani, Catherine Y. Marbehant, Ahmed Essaghir, Fabienne Foufelle, Pascal Ferré, Carl-Henrik Heldin, Nathalie M. Delzenne, Jean-Baptiste Demoulin

Publikováno v: Journal of Lipid Research, Vol 48, Iss 7, Pp 1628-1636 (2007)

Sterol-regulatory element binding proteins (SREBPs) control the expression of genes involved in fatty acid and cholesterol biosynthesis. Using microarrays, we observed that mature SREBP-1 also induced the expression of genes unrelated to lipid metabo

Externí odkaz: https://doaj.org/article/f972e3bf73564631814fb7d3ef4d5db5

Zobrazit plný text záznamu

Akademický článek

The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation

Autor: Federica Toffalini, Anders Kallin, Peter Vandenberghe, Pascal Pierre, Lucienne Michaux, Jan Cools, Jean-Baptiste Demoulin

Publikováno v: Haematologica, Vol 94, Iss 8 (2009)

Background Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRβ (TPβ, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRα

Externí odkaz: https://doaj.org/article/db6db8f50d724e5e900cd20401c59234

Zobrazit plný text záznamu

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity

Autor: Bertil Samuelsson, Anders Kallin, Susana Ayesa, Tatiana Agback, Kurt Benkestock, Ellen Hewitt, Charlotta Lindquist, Björn Classon, Ian Henderson, Dave Sheppard, Katarina Jansson

Publikováno v: Bioorganic & Medicinal Chemistry. 17:1307-1324

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relationship of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295230f1b987846fc6e3fd9b45f1d295
https://doi.org/10.1016/j.bmc.2008.12.020

Zobrazit plný text záznamu

JAK2, the JAK2 V617F mutant and cytokine receptors

Autor: Jean-Baptiste Demoulin, Stefan N. Constantinescu, Carmen-Cristina Diaconu, William Vainchenker, Anders Kallin, Judith Staerk, Alexandra Dusa, Yohan Royer

Publikováno v: Pathologie Biologie. 55:88-91

Recently, a unique recurrent somatic mutation was identified as a major molecular event in polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. Expression of this mutant in cytokine-dependent hematopoietic cell lines induces aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802693bc99aaf0a8887c5304583051d2
https://doi.org/10.1016/j.patbio.2006.06.003

Zobrazit plný text záznamu

Abstract 3011: Development of selective small-molecule inhibitors of cellular MALT1 protease activity

Autor: Anders Kallin, Ian R. Henderson, Mark Albertella, Jimmy Lindberg, Sofia Karlstrom, Fredrik Öberg, Richard Bethell, Ellen Hewitt, Anna-Karin Sohlenius-Sternbeck, Susanne Sedig

Publikováno v: Cancer Research. 76:3011-3011

Background: The aim of this study was to develop potent, selective and cell-permeable inhibitors of MALT1 protease activity. MALT1 is an Arg-specific protease that cleaves multiple substrates, acting as a key component in T- and B-cell receptor signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a23bcbc23aaa245b5f24e6359c8d854c
https://doi.org/10.1158/1538-7445.am2016-3011

Zobrazit plný text záznamu

The Tyrosine Kinase Pyk2 Regulates Arf1 Activity by Phosphorylation and Inhibition of the Arf-GTPase-activating Protein ASAP1

Autor: Anders Kallin, Felix T. Wieland, Jörg Moelleken, Andree Blaukat, Anamarija Kruljac-Letunic

Publikováno v: Journal of Biological Chemistry. 278:29560-29570

Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase structurally related to focal adhesion kinase, has been implicated in the regulation of mitogen-activated protein kinase cascades and ion channels, the induction of apoptosis, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c2af658a7b62b6b778e227130efc21
https://doi.org/10.1074/jbc.m302278200

Zobrazit plný text záznamu

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

Autor: Carl-Henrik Heldin, Simon Ekman, Ulla Engström, Lars Rönnstrand, Anders Kallin

Publikováno v: Lund University

We have previously shown that the binding site for GTPase activating protein of Ras (RasGAP) in the PDGF beta-receptor, Tyr771, is phosphorylated to a much lower extent in the heterodimeric configuration of PDGF alpha- and beta-receptors, compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c44438bb4ac5c822c58f63cc5c175dd
https://doi.org/10.1038/sj.onc.1205210

Zobrazit plný text záznamu

TNF-α Suppresses the PDGF β-Receptor Kinase

Autor: Keiko Funa, Anders Kallin, Lars Rönnstrand, Catrin Molander, Hiroto Izumi

Publikováno v: Experimental Cell Research. 258:65-71

PDGF and TNF-alpha are both known to play important roles in inflammation, albeit frequently by opposing actions. Typically, TNF-alpha can attenuate PDGF beta-receptor signaling. Pretreatment of mouse 3T3 L1 fibroblasts with TNF-alpha greatly diminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d869da614e09e7926a30b0c8d25a76ad
https://doi.org/10.1006/excr.2000.4917

Zobrazit plný text záznamu

[Role of PDGF and FGF receptors in cancer]

Autor: J B, Demoulin, Sandrine, Medves, Federica, Toffalini, Ahmed, Essaghir, Anders, Kallin, Carmen, Montano, Amélie, Velghe, François, Duhoux

Publikováno v: Bulletin et memoires de l'Academie royale de medecine de Belgique. 165(5-6)

Growth factors of the PDGF and FGF families act through receptor tyrosine kinases. These receptors can be activated by chromosomal rearrangements in myeloid neoplasms associated with hypereosinophilia. We identified a new fusion gene between KANK1 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::333d40ea3615e3a0a823f81b23cf62be
https://pubmed.ncbi.nlm.nih.gov/21513119

Zobrazit plný text záznamu

Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data

Autor: Jean-Baptiste Demoulin, Federica Toffalini, Jacques van Helden, Ahmed Essaghir, Anders Kallin, Laurent Knoops

Publikováno v: Nucleic Acids Research
Nucleic acids research, 38 (11
Nucleic acids research, Vol. 38, no. 11, p. e120 (2010)
Nucleic Acids Research, Oxford University Press, 2010, 38 (11)

Deciphering transcription factor networks from microarray data remains difficult. This study presents a simple method to infer the regulation of transcription factors from microarray data based on well-characterized target genes. We generated a catal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f7747f9b9bc7d419b5992cf9fdb093
https://pubmed.ncbi.nlm.nih.gov/20215436

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání