Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anders Heding"'
Autor:
R. Scott Heller, Klaus Stensgaard Frederiksen, Thomas Lindebo Holm, Jan Fleckner, Claus Heiner Bang-Berthelsen, Peter Helding Kvist, Lasse Folkersen, Malene Jackerott, Rolf Søkilde, Lotte Simonsen, Charles Pyke, Mogens Vilien, Anders Heding, Flemming Pociot, Lotte Bjerre Knudsen
Publikováno v:
Inflammatory Bowel Diseases. 22:2078-2097
BACKGROUND: Beneficial roles for glucagon-like peptide 1 (GLP-1)/GLP-1R signaling have recently been described in diseases, where low-grade inflammation is a common phenomenon. We investigated the effects of GLP-1 in Brunner's glands and duodenum wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af561f78ed063845eaffbf06da49465
https://doi.org/10.1097/mib.0000000000000847
https://doi.org/10.1097/mib.0000000000000847
Publikováno v:
Pflugers Archiv : European journal of physiology. 439(Suppl 1)
This study quantified the agonist-induced endocytotic and recycling events of the mammalian gonadotropin releasing hormone receptor (GnRH-R) and investigated the role of the intracellular carboxyl (C)-terminal tail in regulating agonist-induced recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef9906a172e2c7657cdbc320a8f876f
https://pubmed.ncbi.nlm.nih.gov/28176059
https://pubmed.ncbi.nlm.nih.gov/28176059
Beta-Arrestin2 as a Competitor for GRK2 Interaction with the GLP-1 Receptor upon Receptor Activation
Publikováno v:
Pharmacology. 88:174-181
The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbf8adc4cb4505c4be1b50887d5e282
https://doi.org/10.1159/000330742
https://doi.org/10.1159/000330742
Autor:
Nils Billestrup, Dan Ploug Christensen, Rasmus Jorgensen, Lars Groth Grunnet, Nikolaj Kulahin, Vladimir Berezin, Anders Heding, Elisabeth Bock, Morten Lundh, Thomas Mandrup-Poulsen
Publikováno v:
FEBS Letters. 585:58-64
Biological activity of the neural cell adhesion molecule (NCAM) depends on both adhesion and acti-vation of intra-cellular signaling. Based on in vitro experiments with truncated extra-cellulardomains, several models describing homophilic NCAM trans-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4c27bd91b9b80e6902381b43f8fc58
https://doi.org/10.1016/j.febslet.2010.11.043
https://doi.org/10.1016/j.febslet.2010.11.043
Autor:
Milka Vrecl, Dorthe L.C. Almholt, Pia Karina Nørregaard, Azra Pogačnik, Anders Heding, Lisbeth Elster
Publikováno v:
SLAS Discovery. 14:371-380
CB1 receptor (CB1R) antagonists have been demonstrated to be effective in treating obesity and related disorders. This study has been focused on establishing a beta-arrestin 2-based screening assay for the CB1R using BRET2 technology. When the existi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c4d17e51016851abb13c8058650455
https://doi.org/10.1177/1087057109333101
https://doi.org/10.1177/1087057109333101
Autor:
Jesper B. Kristensen, Julie Kønig, Angela Manegold Svendsen, Anna Zalesko, John D. Wade, Ross A. D. Bathgate, Anders Heding, Jane Nøhr, Pierre De Meyts, Milka Vrecl
Publikováno v:
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2008, 296 (1-2), pp.10. ⟨10.1016/j.mce.2008.07.014⟩
Molecular and Cellular Endocrinology, Elsevier, 2008, 296 (1-2), pp.10. ⟨10.1016/j.mce.2008.07.014⟩
H2 relaxin, a member of the insulin superfamily, binds to the G-protein-coupled receptor RXFP1 (relaxin family peptide 1), a receptor that belongs to the leucine-rich repeat (LRR)-containing subgroup (LGRs) of class A GPCRs. We recently demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b9ee8a86ee191ee7824f0fbd64bc13
https://doi.org/10.1016/j.mce.2008.07.014
https://doi.org/10.1016/j.mce.2008.07.014
Autor:
Christian E. Elling, Anders Heding, Rasmus Jorgensen, Nicholas D. Holliday, Jakob Lerche Hansen, Milka Vrecl, Thue W. Schwartz
Publikováno v:
Molecular Pharmacology. 73:349-358
To analyze the interaction between the neurokinin-1 (NK-1) receptor and G-protein coupled receptor kinases (GRKs), we performed bioluminescence resonance energy transfer(2) (BRET(2)) measurements between the family A NK-1 receptor and GRK2 and GRK5 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edcf5668972988e36c3d1f8ccd1624b
https://doi.org/10.1124/mol.107.038877
https://doi.org/10.1124/mol.107.038877
Autor:
Valentina Kubale, Zrinka Abramović, Marjeta Šentjurc, Milka Vrecl, Azra Pogačnik, Anders Heding
Publikováno v:
Cell and Tissue Research. 330:231-245
This study was focused on the relationship between the plasma-membrane localization of neurokinin-1 receptor (NK1-R) and its endocytic and signaling properties. First, we employed electron paramagnetic resonance (EPR) to study the domain structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618a01ca17c741c6252bd2a3d292a22
https://doi.org/10.1007/s00441-007-0462-y
https://doi.org/10.1007/s00441-007-0462-y
Bioluminescence Resonance Energy Transfer as a Screening Assay: Focus on Partial and Inverse Agonism
Publikováno v:
SLAS Discovery. 12:41-49
The reported data for compound screening with the bioluminescence resonance energy transfer (BRET 2 ) assay is very limited, and several questions remain unaddressed, such as the behavior of agonists. Eleven β2 adrenergic receptor (β2-AR) agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c6d895f962162e34d3f9dcb447d02b
https://doi.org/10.1177/1087057106295895
https://doi.org/10.1177/1087057106295895
Publikováno v:
Journal of Receptors and Signal Transduction. 26:505-526
Using bioluminescence resonance energy transfer (BRET) we studied opsin oligomerization in heterologous expression systems and quantitatively assessed its oligomerization state. BRET2 saturation and competition experiments were performed with live CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf08e219258219cc3e7a78dbf2f409b0
https://doi.org/10.1080/10799890600932253
https://doi.org/10.1080/10799890600932253