Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anders H. Olsson"'
Autor:
Karl Bacos, Linn Gillberg, Petr Volkov, Anders H Olsson, Torben Hansen, Oluf Pedersen, Anette Prior Gjesing, Hans Eiberg, Tiinamaija Tuomi, Peter Almgren, Leif Groop, Lena Eliasson, Allan Vaag, Tasnim Dayeh, Charlotte Ling
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islet
Externí odkaz:
https://doaj.org/article/c99faccee14345d89d7f5d0eb1cd3eb0
Autor:
Petr Volkov, Anders H Olsson, Linn Gillberg, Sine W Jørgensen, Charlotte Brøns, Karl-Fredrik Eriksson, Leif Groop, Per-Anders Jansson, Emma Nilsson, Tina Rönn, Allan Vaag, Charlotte Ling
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157776 (2016)
Little is known about the extent to which interactions between genetics and epigenetics may affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We performed a genome-wide DNA methylation quantitative trait locus (mQTL)
Externí odkaz:
https://doaj.org/article/c57acc913a724b73905a1bc69c755f6a
Autor:
Anders H Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, Emma A Nilsson, Claes Ladenvall, Tina Rönn, Charlotte Ling
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004735 (2014)
Genetic and epigenetic mechanisms may interact and together affect biological processes and disease development. However, most previous studies have investigated genetic and epigenetic mechanisms independently, and studies examining their interaction
Externí odkaz:
https://doaj.org/article/af77e46c1fb8475bad6dcdace97a983d
Autor:
Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma Nilsson, Anders H Olsson, Clare L Kirkpatrick, Claes B Wollheim, Lena Eliasson, Tina Rönn, Karl Bacos, Charlotte Ling
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004160 (2014)
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic islets and determine the epigenetic basis of T2D, we analyzed DNA methylation of 479,927 C
Externí odkaz:
https://doaj.org/article/8bf483f6f1ec401a86412784f61c7fba
Autor:
Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, Anders H Olsson, Emma Nilsson, Asa Tornberg, Marloes Dekker Nitert, Karl-Fredrik Eriksson, Helena A Jones, Leif Groop, Charlotte Ling
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003572 (2013)
Epigenetic mechanisms are implicated in gene regulation and the development of different diseases. The epigenome differs between cell types and has until now only been characterized for a few human tissues. Environmental factors potentially alter the
Externí odkaz:
https://doaj.org/article/1f19764cecb8416a9d3bfcadb61b3b39
Autor:
Petr Volkov, Charlotte Brøns, Brynjulf Mortensen, Maren Schrölkamp, Charlotte Ling, Allan Vaag, Alexander Perfilyev, Ninna S. Hansen, Rasmus Ribel-Madsen, Jørgen F. P. Wojtaszewski, Linn Gillberg, Sine W. Jørgensen, Bente Klarlund Pedersen, Janne R. Hingst, Christa Broholm, Anders H. Olsson, Juliane Maria Dorothee Ahlers, Camilla Scheele, Line Hjort
Publikováno v:
Endocrine research. 45(1)
Background: Being born with low birth weight (LBW) is a risk factor for muscle insulin resistance and type 2 diabetes (T2D), which may be mediated by epigenetic mechanisms programmed by the intrauterine environment. Epigenetic mechanisms exert their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9034bd018c8cf4c2e4b7fc780f90bf55
https://pubmed.ncbi.nlm.nih.gov/31566019
https://pubmed.ncbi.nlm.nih.gov/31566019
Autor:
Ninna S. Hansen, Alexander Perfilyev, Camilla Scheele, Rasmus Ribel-Madsen, Klaudia Stanislawa Strasko, Maren Schrölkamp, Allan Vaag, Sine W. Jørgensen, Anders H. Olsson, Brynjulf Mortensen, Charlotte Ling, Christa Broholm
Publikováno v:
Diabetologia. 59:2664-2673
Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2863a4217c8172c17c7a7bff454b8a9e
https://doi.org/10.1007/s00125-016-4099-9
https://doi.org/10.1007/s00125-016-4099-9
Autor:
Anders H. Olsson, Louise G. Grunnet, Cuilin Zhang, Charlotte Ling, Allan Vaag, Richard Saffery, Sjurdur F. Olsen, Line Hjort, Haroon Naeem, Jovana Maksimovic, David Martino
Publikováno v:
Hjort, L, Martino, D, Grunnet, L G, Naeem, H, Maksimovic, J, Olsson, A H, Zhang, C, Ling, C, Olsen, S F, Saffery, R & Vaag, A A 2018, ' Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children ', JCI Insight, vol. 3, no. 17, e122572 . https://doi.org/10.1172/jci.insight.122572
Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946a793c09bcf8db2ed3e82898c61a7e
https://doi.org/10.1172/jci.insight.122572
https://doi.org/10.1172/jci.insight.122572
Publikováno v:
Diabetologia
Diabetologia; 56(5), pp 1036-1046 (2013)
Diabetologia; 56(5), pp 1036-1046 (2013)
Aims/hypothesis To date, the molecular function of most of the reported type 2 diabetes-associated loci remains unknown. The introduction or removal of cytosine–phosphate–guanine (CpG) dinucleotides, which are possible sites of DNA methylation, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da4513f6fb2084926cb12c62fc9538c
https://doi.org/10.1007/s00125-012-2815-7
https://doi.org/10.1007/s00125-012-2815-7
Autor:
Charlotte Ling, Allan Vaag, Alexander Perfilyev, Ninna S. Hansen, Adnan Ali, Anders H. Olsson, Christa Broholm, Linn Gillberg, Brynjulf Mortensen
Publikováno v:
Epigenomics. 8(12)
Aim: To define the genomic distribution and function of DNA methylation changes during human adipogenesis. Methods: We isolated adipocyte-derived stem cells from 13 individuals and analyzed genome-wide DNA methylation and gene expression in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1a618cc7e75db96b0c4c9bcb079425
https://pubmed.ncbi.nlm.nih.gov/27854126
https://pubmed.ncbi.nlm.nih.gov/27854126