Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Anders Gunnarsson"'
Autor:
Alena Ivanova, Lukas Badertscher, Gwen O'Driscoll, Joakim Bergman, Euan Gordon, Anders Gunnarsson, Camilla Johansson, Michael J. Munson, Cristiana Spinelli, Sara Torstensson, Liisa Vilén, Andrei Voirel, John Wiseman, Janusz Rak, Niek Dekker, Elisa Lázaro‐Ibáñez
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the repurposing of extracellular vesicles (EVs) as drug delivery vehicles are explored. Target
Externí odkaz:
https://doaj.org/article/e1d689279e454812aab0d9be5d04dcd4
Autor:
Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Several neurodegenerative diseases are characterized by the aggregation of cytoplasmic proteins. Here, the authors demonstrate that the small molecule SMER28 activates VCP, which enhances both autophagic and proteasomal clearance of aggregate-prone p
Externí odkaz:
https://doaj.org/article/02631720e7494834abf742bdf764ec8e
Autor:
Jenny Hering, Julie Winkel Missel, Liying Zhang, Anders Gunnarsson, Marie Castaldo, Per Amstrup Pedersen, Margareta Ek, Pontus Gourdon, Harm Jan Snijder
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Overproduction and purification of membrane proteins are generally challenging and time-consuming procedures due to low expression levels, misfolding, and low stability once extracted from the membrane. Reducing processing steps and shorteni
Externí odkaz:
https://doaj.org/article/4c535154a4b94033a5001d882e93a6d6
Autor:
Andreia M. Silva, Elisa Lázaro‐Ibáñez, Anders Gunnarsson, Aditya Dhande, George Daaboul, Ben Peacock, Xabier Osteikoetxea, Nikki Salmond, Kristina Pagh Friis, Olga Shatnyeva, Niek Dekker
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)
Abstract Extracellular Vesicles (EVs) have been intensively explored for therapeutic delivery of proteins. However, methods to quantify cargo proteins loaded into engineered EVs are lacking. Here, we describe a workflow for EV analysis at the single
Externí odkaz:
https://doaj.org/article/2ca44902d95e4a328a40c83c1e76dc25
Autor:
Rikke Christensen, David M. Owens, Annette C. Füchtbauer, Anders Gunnarsson, Mette Ramsing, Ernst-Martin Füchtbauer, Uffe Birk Jensen
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 109-118 (2017)
The cell surface protein Stem Cell Antigen-1 (Sca-1) marks stem or progenitor cells in several murine tissues and is normally upregulated during cancer development. Although the specific function of Sca-1 remains unknown, Sca-1 seems to play a role i
Externí odkaz:
https://doaj.org/article/4c558139ed2e4a29a610f8e9b2053272
Autor:
Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193380 (2018)
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperka
Externí odkaz:
https://doaj.org/article/837696cf2e364f56bb14da55aad00b11
Autor:
Vanessa J. Hall, Maiken M. Lindblad, Jannik E. Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A. Rasmussen, Daniela Volke, Thole Zuchner, Poul Hyttel
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 10, Pp 1265-1278 (2015)
Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for t
Externí odkaz:
https://doaj.org/article/1ae96c90f34c49eea32435feaf739d80
Autor:
Nazma F. Ilahibaks, Arif I. Ardisasmita, Songpu Xie, Anders Gunnarsson, Joseph Brealey, Pieter Vader, Olivier G. de Jong, Saskia de Jager, Niek Dekker, Ben Peacock, Raymond M. Schiffelers, Joost P.G. Sluijter, Zhiyong Lei
Publikováno v:
Journal of Controlled Release. 355:579-592
Autor:
Sandra Postel, Lisa Wissler, Carina A. Johansson, Anders Gunnarsson, Euan Gordon, Barry Collins, Marie Castaldo, Christian Köhler, David Öling, Patrik Johansson, Linda Fröderberg Roth, Brice Beinsteiner, Ian Dainty, Stephen Delaney, Bruno P. Klaholz, Isabelle M. L. Billas, Karl Edman
Publikováno v:
Nature Structural & Molecular Biology. 30:286-295
Autor:
Jakob S. Pallesen, Claire C. Munier, Francesco Bosica, Sebastian A. Andrei, Karl Edman, Anders Gunnarsson, Giuseppina La Sala, Okky Dwichandra Putra, Sonja Srdanović, Andrew J. Wilson, Lisa Wissler, Christian Ottmann, Matthew W. D. Perry, Gavin O’Mahony
Publikováno v:
Journal of Medicinal Chemistry, 65(24), 16818-16828. American Chemical Society
The ubiquitously expressed glucocorticoid receptor (GR) is a nuclear receptor that controls a broad range of biological processes and is activated by steroidal glucocorticoids such as hydrocortisone or dexamethasone. Glucocorticoids are used to treat