Development of a 64Cu-labeled CD4+ T cell targeting PET tracer: evaluation of CD4 specificity and its potential use in collagen-induced arthritis

Autor: Anne Skovsbo Clausen, Camilla Christensen, Esben Christensen, Sigrid Cold, Lotte Kellemann Kristensen, Anders Elias Hansen, Andreas Kjaer

Publikováno v: EJNMMI Research, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Background CD4+ T cells are central inflammatory mediators in the pathogenesis of autoimmune rheumatoid arthritis (RA), as they are one of the dominating cell types in synovial inflammation. Molecular imaging of CD4+ T cells has potential ro

Externí odkaz: https://doaj.org/article/e6d4e37598b0485597ba78e216aa879d

Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response

Autor: Frederikke Petrine Fliedner, Trine Bjørnbo Engel, Henrik H. El-Ali, Anders Elias Hansen, Andreas Kjaer

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)

Abstract Background Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in cellular density of

Externí odkaz: https://doaj.org/article/ff12dead0597488d963e088ae9ea9b17

Effect of apoA‑I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins

Autor: Lars Ringgaard, Katrine Jønsson, Louise Krogager, Jens B. Simonsen, Camilla Hald Albertsen, Dennis Pedersbæk, Andreas Kjaer, Jannik B. Larsen, Anders Elias Hansen, Thomas Lars Andresen

Publikováno v: ACS Omega, Vol 6, Iss 1, Pp 871-880 (2020)
Pedersbæk, D, Krogager, L, Albertsen, C H, Ringgaard, L, Hansen, A E, Jønsson, K, Larsen, J B, Kjær, A, Andresen, T L & Simonsen, J B 2021, ' Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins ', ACS Omega, vol. 6, no. 1, pp. 871-880 . https://doi.org/10.1021/acsomega.0c05468
Pedersbæk, D, Krogager, L, Gregersen, C H, Ringgaard, L, Hansen, A E, Jønsson, K, Larsen, J B, Kjær, A, Andresen, T L & Simonsen, J B 2021, ' Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins ', ACS Omega, vol. 6, no. 1, pp. 871-880 . https://doi.org/10.1021/acsomega.0c05468
ACS Omega

Biomimetic high-density lipoproteins (b-HDL) have in the past two decades been applied for various drug delivery applications. As b-HDL inherently have relatively long circulation half-life and high tumor accumulation, this has inspired researchers t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0979fba97c329721bcf3960cc2f54b
https://doaj.org/article/c59234b1e39344ffaad670023bf12b2c

Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system

Autor: Anders Elias Hansen, Johan Tham, Andreas Tue Ingemann Jensen, Andreas Kjaer, Thomas Lars Andresen, Jonas Rosager Henriksen, Daniella Elisabet Østergaard, Petter Holmberg, Peter Damborg, Anne Skovsbo Clausen

Publikováno v: Journal of Controlled Release. 327:737-746

Background Therapeutic interventions for infectious and inflammatory diseases are becoming increasingly challenging in terms of therapeutic resistance and side-effects. Theranostic systems to ameliorate diagnosis and therapy are therefore highly warr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e255602f2943553b9ca8548d71118c59
https://doi.org/10.1016/j.jconrel.2020.09.018

Development of a

Autor: Anne Skovsbo, Clausen, Camilla, Christensen, Esben, Christensen, Sigrid, Cold, Lotte Kellemann, Kristensen, Anders Elias, Hansen, Andreas, Kjaer

Publikováno v: EJNMMI research. 12(1)

CD4The tracer, [We developed and evaluated a new radiotracer, [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a2257cbf0aa9b644bbba3351ab27d30
https://pubmed.ncbi.nlm.nih.gov/36114433