Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anders E. G. Lindgren"'
Autor:
Elisabeth Reithuber, Priyanka Nannapaneni, Olena Rzhepishevska, Anders E. G. Lindgren, Oleksandr Ilchenko, Staffan Normark, Fredrik Almqvist, Birgitta Henriques-Normark, Peter Mellroth
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could
Externí odkaz:
https://doaj.org/article/37a7655286df455188901d9598d4a006
Autor:
Taylor M. Nye, Hasan Tükenmez, Pardeep Singh, Ana L. Flores-Mireles, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Souvik Sarkar, Mari Bonde, Anders E. G. Lindgren, Karen W. Dodson, Jörgen Johansson, Fredrik Almqvist, Michael G. Caparon, Scott J. Hultgren
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9a61366ca4e9623d2b9e75c6e13bfa
https://doi.org/10.1073/pnas.2210912119
https://doi.org/10.1073/pnas.2210912119
Autor:
Jörgen Ådén, Pardeep Singh, Mohit Tyagi, Sanduni Wasana Jayaweera, Anders Olofsson, Adrian Deuschmann, Fredrik Almqvist, Anna L. Gharibyan, Anders E. G. Lindgren, Dan E. Adolfsson
Publikováno v:
The Journal of Organic Chemistry
A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with a range of O-alkylated salicylaldehydes and amino functionalized thiazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc585e0880abcb5117ac3b4539093182
https://doi.org/10.1021/acs.joc.0c01699
https://doi.org/10.1021/acs.joc.0c01699
Autor:
Martina Kulén, Christer Larsson, Fredrik Almqvist, K. Syam Krishnan, Erik Chorell, James A. D. Good, Mette R. Hansen, Gregory A. Harrison, Dennis X. Zhu, Jonathan Livny, Scott J. Hultgren, Kelly Flentie, Christina L. Stallings, Anders E. G. Lindgren, Leslie A. Weiss, Torbjörn Wixe, Hasan Tükenmez, Andrew G. Cairns, Christoffer Bengtsson, Souvik Sarkar, Samantha D. Solomon, Miranda E. Schene, Rachel L. Kinsella
Publikováno v:
Proceedings of the National Academy of Sciences. 116:10510-10517
Mycobacterium tuberculosis ( Mtb ) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses imposed by the immune system and tolerate exposure to antibiotics, resulting in persistent inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc38cc536017cb4fd2b8f71cbd16357
https://doi.org/10.1073/pnas.1818009116
https://doi.org/10.1073/pnas.1818009116
Autor:
Fredrik Almqvist, Priyanka Nannapaneni, Tanja Schneider, Hanna Uvell, Anna Eriksson, Elisabeth Reithuber, Anders E. G. Lindgren, Birgitta Henriques-Normark, Sandra Muschiol, Anna Müller, Peter Mellroth, Kevin C. Ludwig, Fabian Grein, Staffan Normark, Torbjörn Wixe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Considering the alarming emergence of resistance to most antibiotics and the need for new antibiotics, the finding here of a small-molecule class, THCz, that displayed bactericidal activity against gram-positive and selected gram-negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c90680bd76adf39525fff323412542
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191611
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191611
Autor:
Kelly, Flentie, Gregory A, Harrison, Hasan, Tükenmez, Jonathan, Livny, James A D, Good, Souvik, Sarkar, Dennis X, Zhu, Rachel L, Kinsella, Leslie A, Weiss, Samantha D, Solomon, Miranda E, Schene, Mette R, Hansen, Andrew G, Cairns, Martina, Kulén, Torbjörn, Wixe, Anders E G, Lindgren, Erik, Chorell, Christoffer, Bengtsson, K Syam, Krishnan, Scott J, Hultgren, Christer, Larsson, Fredrik, Almqvist, Christina L, Stallings
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f95775346e9eccdc954e92cd619078b
https://pubmed.ncbi.nlm.nih.gov/31176512
https://pubmed.ncbi.nlm.nih.gov/31176512
Autor:
Pardeep Singh, Sven Bergström, Jim Silver, Katarina Vielfort, Fredrik Almqvist, Wael Bahnan, Anders E. G. Lindgren, Åsa Gylfe, Emma Wede, Martina Kulén, James A. D. Good, Richard Svensson, Andrew G. Cairns, Carlos Núñez-Otero
Publikováno v:
MedChemComm
Methyl sulfonamide substituents effectively improve the pharmacokinetic properties of bicyclic 2-pyridones, a new class of Chlamydia trachomatis infectivity inhibitors.
Chlamydia trachomatis infections are a global health problem and new approac
Chlamydia trachomatis infections are a global health problem and new approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24e219c628fe409a53bb793792b9e80
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166479
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166479
Autor:
Sanja Juric, Janet Hoogstraate, Tjerk Bueters, Margareta Bergh, Olle Gissberg, Yin Hu, Pawel Baranczewski, Jenny U. Johansson, Juliette Janson, Carrie Tsoi, Anna Breitholtz-Emanuelsson, Anders E. G. Lindgren, Sveinn Briem, Anna-Karin Sohlenius-Sternbeck, Johan Bylund
Publikováno v:
Current Drug Metabolism. 17:253-270
Background: The disposition of a drug is dependent on interactions between the body and the drug, its molecular properties and the physical and biological barriers presented in the body. In order for a drug to have a desired pharmacological effect it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d040509b920ac9ebcf3db07401db1e
https://doi.org/10.2174/1389200217666151210125637
https://doi.org/10.2174/1389200217666151210125637
Autor:
Herwig Schüler, T. Ekblad, Tomas Nyman, Anders E. G. Lindgren, Mikael Elofsson, Patricia Verheugd
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(4)
Macrodomains recognize intracellular adenosine diphosphate (ADP)-ribosylation resulting in either removal of the modification or a protein interaction event. Research into compounds that modulate macrodomain functions could make important contributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52bf382ededb81ed94ceeb6fa5fa843
https://pubmed.ncbi.nlm.nih.gov/29316839
https://pubmed.ncbi.nlm.nih.gov/29316839
Autor:
Hanna Uvell, Åsa Gylfe, Mikael Elofsson, Anders E. G. Lindgren, Olli Salin, Sania Marwaha, Jim Silver
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:2968-2971
Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2790e1c8b445bcdff7870bc20c712adc
https://doi.org/10.1128/aac.02015-13
https://doi.org/10.1128/aac.02015-13